Results 51 to 60 of about 7,006 (230)

The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface.

Current Biology, 2021
The midbody at the center of the intercellular bridge connecting dividing cells recruits the machinery essential for the final steps of cytokinesis.1-5 Successive abscission on both sides of the midbody generates a free midbody remnant (MBR) that can be ...
Adrien Presle, S. Frémont, A. Salles, P. Commere, N. Sassoon, C. Berlioz-Torrent, Neetu Gupta-Rossi, A. Echard   +7 more
semanticscholar   +1 more source

Substitutions in Nef That Uncouple Tetherin and SERINC5 Antagonism Impair Simian Immunodeficiency Virus Replication in Primary Rhesus Macaque Lymphocytes

Journal of Virology, 2022
Tetherin is an interferon-inducible transmembrane protein that prevents the detachment of enveloped viruses from infected cells by physically tethering nascent virions to cellular membranes.
S. Janaka, Brian J. Snow, Ryan T. Behrens, David T. Evans   +3 more
semanticscholar   +1 more source

Stem-cell-based gene therapy for HIV infection. [PDF]

, 2013
Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
core   +2 more sources

Zn‐Induced Interactions Between SARS‐CoV‐2 orf7a and BST2/Tetherin

ChemistryOpen, 2021
We present in this work a first X‐ray Absorption Spectroscopy study of the interactions of Zn with human BST2/tetherin and SARS‐CoV‐2 orf7a proteins as well as with some of their complexes.
M. Petrosino, F. Stellato, R. Chiaraluce, V. Consalvi, G. La Penna, A. Pasquo, O. Proux, G. Rossi, S. Morante   +8 more
semanticscholar   +1 more source

In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.

PLoS ONE, 2014
The interferon-inducible cellular protein tetherin (CD317/BST-2) inhibits the release of a broad range of enveloped viruses. The HIV-1 accessory protein Vpu enhances virus particle release by counteracting this host restriction factor.
Abdul A Waheed, Nishani D Kuruppu, Kathryn L Felton, Darren D'Souza, Eric O Freed   +4 more
doaj   +1 more source

Ultra Structural Characterisation of Tetherin - a Protein Capable of Preventing Viral Release from the Plasma Membrane

Viruses, 2010
Tetherin is an antiviral restriction factor made by mammalian cells to protect them from viral infection. It prevents newly formed virus particles from leaving infected cells. Its antiviral mechanism appears to be remarkably uncomplicated.
Ravindra K. Gupta, Greg J. Towers
doaj   +1 more source

Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

bioRxiv, 2021
The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae. Tetherin is an interferon-induced protein that forms parallel homodimers between the host cell and viral ...
Hazel Stewart, Roberta Palmulli, K. H. Johansen, Naomi McGovern, O. M. Shehata, George William Carnell, Hannah K. Jackson, Jin S Lee, Jonathan C. Brown, T. Burgoyne, J. L. Heeney, Klaus Okkenhaug, A. E. Firth, Andrew A. Peden, James R. Edgar   +14 more
semanticscholar   +1 more source

Mechanism of Tetherin Inhibition of Alphavirus Release [PDF]

Journal of Virology, 2019
The mechanisms of tetherin’s antiviral activities and viral tetherin antagonism have been studied in detail for a number of different viruses. Although viral countermeasures against tetherin can differ significantly, overall, tetherin’s antiviral activity correlates with physical tethering of virus particles to prevent their release. While tetherin can
Judy J. Wan, Yaw Shin Ooi, Margaret Kielian   +2 more
openaire   +2 more sources

Parkinson’s Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread

Cells, 2021
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, characterized by progressive loss of dopaminergic neurons in the substantia nigra, intraneuronal deposition of misfolded proteins known as Lewy bodies, and chronic ...
Yingzhuo Ding, Yan Li, Gaurav Chhetri, Xiao-Lan Peng, Jing Wu, Zejian Wang, Bo Zhao, Wenjuan Zhao, Xueyi Li   +8 more
semanticscholar   +1 more source

Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.

PLoS Pathogens, 2010
The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface.
Mathieu Dubé, Bibhuti Bhusan Roy, Pierre Guiot-Guillain, Julie Binette, Johanne Mercier, Antoine Chiasson, Eric A Cohen   +6 more
doaj   +1 more source