Results 51 to 60 of about 4,158 (155)
CAML does not modulate tetherin-mediated restriction of HIV-1 particle release.
PLoS ONE, 2010 BackgroundTetherin/BST-2 is a recently-identified potent restriction factor in human cells that restricts HIV particle release following particle formation and budding at the plasma membrane.
Mohammed S Ali +3 more
doaj +1 more source
, 2013 (A) Vpu counteracts human but not murine tetherin antiviral activity. 293T cells were transfected with an HIV-1 provirus either proficient or deficient for the Vpu gene, together with the indicated tetherin constructs.
Madeleine Zufferey (359889) +5 more
core +1 more source
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathogens, 2013 Tetherin (Bst2/CD317/HM1.24) is an interferon-induced antiviral host protein that inhibits the release of many enveloped viruses by tethering virions to the cell surface.
Matthew W McNatt +2 more
doaj +1 more source
Cancer Science, Volume 117, Issue 1, Page 130-144, January 2026.We characterized colorectal cancer stem‐like cell (CRC‐SC)–derived transcriptomic subtypes based on mRNA expression of 57 patient‐derived SC lines. Expression profiles were compared with normal colonic epithelium stem‐like cells (NCE‐SCs), yielding differentially expressed genes.
Fumihiko Kakizaki +13 more
wiley +1 more source
Cloning and characterization of the antiviral activity of feline Tetherin/BST-2.
PLoS ONE, 2011 Human Tetherin/BST-2 has recently been identified as a cellular antiviral factor that blocks the release of various enveloped viruses. In this study, we cloned a cDNA fragment encoding a feline homolog of Tetherin/BST-2 and characterized the protein ...
Aiko Fukuma +4 more
doaj +1 more source
Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy
The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro +2 more
wiley +1 more source
Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.
PLoS Pathogens, 2009 The recently identified restriction factor tetherin/BST-2/CD317 is an interferon-inducible trans-membrane protein that restricts HIV-1 particle release in the absence of the HIV-1 countermeasure viral protein U (Vpu). It is known that Tantalus monkey CV1
Ravindra K Gupta +5 more
doaj +1 more source
Structural basis of tetherin function.
, 2012 International audienceHIV-1 employs its structural proteins to orchestrate assembly and budding at the plasma membrane of host cells, which depends on numerous cellular factors.
Aschman, Nick +6 more
core +1 more source
Cell Proliferation, Volume 58, Issue 11, November 2025.CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far +4 more
wiley +1 more source
Higher inhibition of virion release by NZW Tetherin versus B6 Tetherin in vitro.
, 2012 (A) Cellular FV infection levels. Co-transfection of an infectious F-MuLV molecular clone (1 µg) and Tetherin constructs (50 ng) revealed significant cellular FV envelope gp70 expression by flow cytometry of permeabilized cells following staining with ...
Bradley S. Barrett (176100) +5 more
core +1 more source