Results 61 to 70 of about 7,006 (230)

Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells.

PLoS ONE, 2012
The interferon-induced host cell factor tetherin inhibits release of human immunodeficiency virus (HIV) from the plasma membrane of infected cells and is counteracted by the HIV-1 protein Vpu.
Michael Winkler, Stephanie Bertram, Kerstin Gnirß, Inga Nehlmeier, Ali Gawanbacht, Frank Kirchhoff, Christina Ehrhardt, Stephan Ludwig, Miriam Kiene, Anna-Sophie Moldenhauer, Ulrike Goedecke, Christina B Karsten, Annika Kühl, Stefan Pöhlmann   +13 more
doaj   +1 more source

CD317/Tetherin is an organiser of membrane microdomains [PDF]

Journal of Cell Science, 2013
The integral membrane protein tetherin has been associated with an eclectic mix of cellular processes, including restricting the release of a range of enveloped viruses from infected cells. The unusual topology of tetherin (it possesses both a conventional transmembrane domain and a glycosylphosphatidylinositol anchor), its localisation to membrane ...
Billcliff, Peter G., Rollason, Ruth, Prior, Ian, Owen, Dylan M., Gaus, Katharina, Banting, George   +5 more
openaire   +3 more sources

The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin.

PLoS Pathogens, 2010
Tetherin (CD317/BST2) is an interferon-induced membrane protein that inhibits the release of diverse enveloped viral particles. Several mammalian viruses have evolved countermeasures that inactivate tetherin, with the prototype being the HIV-1 Vpu ...
Claire Pardieu, Raphaël Vigan, Sam J Wilson, Alessandra Calvi, Trinity Zang, Paul Bieniasz, Paul Kellam, Greg J Towers, Stuart J D Neil   +8 more
doaj   +1 more source

Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling.

Blood Advances, 2021
The reactivity of platelets, which play a key role in the pathogenesis of atherothrombosis, is tightly regulated. The integral membrane protein tetherin/bone marrow stromal antigen-2 (BST-2) regulates membrane organization, altering both lipid and ...
Xiaojuan Zhao, D. Alibhai, T. Sun, Jawad S Khalil, J. Hutchinson, Kaya Olzak, C. Williams, Yong Li, R. Sessions, S. Cross, Richard Seager, R. Aungraheeta, Alan D. Leard, C. McKinnon, D. Phillips, Lei Zhang, A. Poole, G. Banting, S. Mundell   +18 more
semanticscholar   +1 more source

Structural Basis for the Antiviral Activity of BST-2/Tetherin and Its Viral Antagonism [PDF]

, 2011
The interferon-inducible host restriction factor bone marrow stromal antigen 2 (BST-2/tetherin) blocks the release of HIV-1 and other enveloped viruses.
Juan F. Arias, Yukie Iwabu, Kenzo Tokunaga   +2 more
core   +2 more sources

Analysis of Determinants in Filovirus Glycoproteins Required for Tetherin Antagonism

Viruses, 2014
The host cell protein tetherin can restrict the release of enveloped viruses from infected cells. The HIV-1 protein Vpu counteracts tetherin by removing it from the site of viral budding, the plasma membrane, and this process depends on specific ...
Kerstin Gnirß, Marie Fiedler, Annika Krämer-Kühl, Sebastian Bolduan, Eva Mittler, Stephan Becker, Michael Schindler, Stefan Pöhlmann   +7 more
doaj   +1 more source

Site-Directed Mutagenesis of HIV-1 vpu Gene Demonstrates Two Clusters of Replication-Defective Mutants with Distinct Ability to Down-Modulate Cell Surface CD4 and Tetherin [PDF]

, 2010
HIV-1 Vpu acts positively on viral infectivity by mediating CD4 degradation in endoplasmic reticulum and enhances virion release by counteracting a virion release restriction factor, tetherin.
Masako Nomaguchi, Naoya Doi, Sachi Fujiwara, Mikako Fujita, Akio Adachi   +4 more
core   +1 more source

Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction.

PLoS Pathogens, 2011
Virus assembly and interaction with host-cell proteins occur at length scales below the diffraction limit of visible light. Novel super-resolution microscopy techniques achieve nanometer resolution of fluorescently labeled molecules.
Martin Lehmann, Susana Rocha, Bastien Mangeat, Fabien Blanchet, Hiroshi Uji-I, Johan Hofkens, Vincent Piguet   +6 more
doaj   +1 more source

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin. [PDF]

, 2016
Tetherin (BST2/CD317) is a viral restriction factor that anchors enveloped viruses to host cells and limits viral spread. The HIV-1 Vpu accessory protein counteracts tetherin by decreasing its cell surface expression and targeting it for ubiquitin ...
Davis, Luther J, Lehner, Paul J, Paul Luzio, J, Rapiteanu, Radu, Timms, Richard T, Williamson, James C   +5 more
core   +2 more sources

Overexpression of inactive tetherin delGPI mutant inhibits HIV‐1 Vpu‐mediated antagonism of endogenous tetherin

FEBS Letters, 2012
Vpu and etherin colocalize by fluorescence (View interaction) Tetherin physically interacts with Vpu by anti tag coimmunoprecipitation (View interaction)
Lv, Mingyu, Wang, Jiawen, Zhu, Yingzi, Wang, Xiaodan, Zuo, Tao, Liu, Donglai, Zhang, Jingyao, Wu, Jiaxin, Zhang, Haihong, Kong, Wei, Yu, Xianghui   +10 more
openaire   +2 more sources