Results 61 to 70 of about 4,158 (155)
Lysosomal degradation of tetherin.
, 2013 A.and B. Triple label fluorescence analysis (antibody detection of Vpu, tetherin and TGN46, and LysoTracker detection of lysosomes) of HeLa cells that had been incubated in the presence of lysosomal inhibitors for 24 hours prior to processing for ...
George Banting (331791) +7 more
core +1 more source
Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Microvesicles are cell membrane–derived vesicles that have been shown to augment inflammation. Specifically, monocyte‐derived microvesicles (MDMVs), which can express the coagulation protein tissue factor, contribute to thrombus formation and ...
Emily A. Weber +7 more
doaj +1 more source
The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling
Advanced Science, Volume 12, Issue 33, September 4, 2025.The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu +17 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.ABSTRACT In spite of the numerous clinical trials conducted on mesenchymal stromal cells and their extracellular vesicles (MSC‐EVs) across a wide range of diseases, the field faces challenges in reaching a consensus on crucial parameters such as source, marker definition, and culture conditions, adding to heterogeneous efficiencies. Nevertheless, there
Anton Selich +7 more
wiley +1 more source
Resilience of BST-2/Tetherin structure to single amino acid substitutions [PDF]
PeerJ, 2019 Human tetherin, also known as BST-2 or CD317, is a dimeric, extracellular membrane-bound protein that consists of N and C terminal membrane anchors connected by an extracellular domain.
Ian R. Roy +2 more
doaj +2 more sources
β-TrCP-mediated tetherin degradation is required for Vpu to counteract IFN-α-induced tetherin.
, 2013 (A) β-TrCP interaction motif is required for Vpu-induced depletion of endogenous tetherin. 293T cells were co-transfected with HIV-1 ΔVpu in addition to the indicated Vpu constructs (with a Vpu∶provirus molar ratio of 3∶1).
Madeleine Zufferey (359889) +5 more
core +1 more source
PLoS ONE, 2012 In different primate lentiviruses, three proteins (Vpu, Env and Nef) have been shown to have anti-tetherin activities. SIVden is a primate lentivirus harbored by a Cercopithecus denti (C. denti) whose genome code for a Vpu gene.
Kristina Nikovics +5 more
doaj +1 more source
In Silico Insights into HIV-1 Vpu-Tetherin Interactions and Its Mutational Counterparts
Medical Sciences, 2019 Tetherin, an interferon-induced host protein encoded by the bone marrow stromal antigen 2 (BST2/CD317/HM1.24) gene, is involved in obstructing the release of many retroviruses and other enveloped viruses by cross-linking the budding virus particles to ...
Patil Sneha +2 more
doaj +1 more source
The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.
PLoS ONE, 2011 Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl +6 more
doaj +1 more source
The Nef Protein of the Macrophage Tropic HIV-1 Strain AD8 Counteracts Human BST-2/Tetherin
Viruses, 2020 Bone Marrow Stromal Cell Antigen 2 (BST-2)/tetherin inhibits the release of numerous enveloped viruses by physically tethering nascent particles to infected cells during the process of viral budding from the cell surface.
Sebastian Giese +4 more
doaj +1 more source