Results 81 to 90 of about 7,006 (230)

HIV-1 BF intersubtype recombinant Vpu second alpha helix plays an important role in the viral release and BST-2 degradation [PDF]

, 2013
We previously reported a naturally occurring BF intersubtype recombinant Vpu variant with augmented capacity to enhance viral replication. Structural analysis of this variant revealed that its transmembrane domain (TMD) and α-helix I in the cytoplasmic ...
Carobene, Mauricio, de Candia, Cristian Ariel, Duette, Gabriel, Espada, Constanza Eleonora, Salomon, Horacio Eduardo   +4 more
core   +1 more source

SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.

PLoS Pathogens, 2011
Lentiviral Nef proteins have multiple functions and are important for viral pathogenesis. Recently, Nef proteins from many simian immunodefiency viruses were shown to antagonize a cellular antiviral protein, named Tetherin, that blocks release of viral ...
Fengwen Zhang, Wilmina N Landford, Melinda Ng, Matthew W McNatt, Paul D Bieniasz, Theodora Hatziioannou   +5 more
doaj   +1 more source

Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane.

PLoS Pathogens, 2010
Tetherin/BST2 was identified in 2008 as the cellular factor responsible for restricting HIV-1 replication at a very late stage in the lifecycle. Tetherin acts to retain virion particles on the plasma membrane after budding has been completed.
Jason Hammonds, Jaang-Jiun Wang, Hong Yi, Paul Spearman   +3 more
doaj   +1 more source

Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin

PLoS Pathogens
BST2/Tetherin is a restriction factor with broad antiviral activity against enveloped viruses, including coronaviruses. Specifically, BST2 traps nascent particles to membrane compartments, preventing their release and spread.
Yuhang Shi, Sydney Simpson, Yuexuan Chen, Haley Aull, J. Benjamin, Ruth Serra-Moreno   +5 more
semanticscholar   +1 more source

Comprehensive Colorectal Cancer Stem Cell Transcriptomic Signatures That Can Predict Patient Prognostic Outcomes

Cancer Science, Volume 117, Issue 1, Page 130-144, January 2026.
We characterized colorectal cancer stem‐like cell (CRC‐SC)–derived transcriptomic subtypes based on mRNA expression of 57 patient‐derived SC lines. Expression profiles were compared with normal colonic epithelium stem‐like cells (NCE‐SCs), yielding differentially expressed genes.
Fumihiko Kakizaki, Hiroyuki Miyoshi, Takehito Yamamoto, Tomonori Morimoto, Hiroyuki Matsubara, Shoichi Kitano, Tadayoshi Yamaura, Hisatsugu Maekawa, J. B. Brown, Tosiya Shun Sato, Kazutaka Obama, Yoshiharu Sakai, Kenji Kawada, Makoto Mark Taketo   +13 more
wiley   +1 more source

Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection [PDF]

, 2017
Tick-borne encephalitis virus (TBEV) is a member of the genus Flavivirus. It can cause serious infections in humans that may result in encephalitis/meningoencephalitis. Although several studies have described the involvement of specific genes in the host
Grubhoffer, Libor, Gu, Quan, Kohl, Alain, Schnettler, Esther, Selinger, Martin, Tong, Lily, Wilkie, Gavin S.   +6 more
core   +2 more sources

Antiviral Activity and Adaptive Evolution of Avian Tetherins

Journal of Virology, 2020
Birds are important hosts of viruses that have the potential to cause zoonotic infections in humans. However, only a few antiviral genes (called viral restriction factors) have been described in birds, mostly because birds lack counterparts of highly studied mammalian restriction factors.
Veronika, Krchlíková, Helena, Fábryová, Tomáš, Hron, Janet M, Young, Anna, Koslová, Jiří, Hejnar, Klaus, Strebel, Daniel, Elleder   +7 more
openaire   +3 more sources

The role of BST2/tetherin in feline retrovirus infection [PDF]

Veterinary Immunology and Immunopathology, 2011
Pathogenic retroviral infections of mammals have induced the evolution of cellular anti-viral restriction factors and have shaped their biological activities. This intrinsic immunity plays an important role in controlling viral replication and imposes a barrier to viral cross-species transmission.
Dietrich, Isabelle, Hosie, Margaret J., Willett, Brian J.   +2 more
openaire   +3 more sources

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

bioRxiv
The introduction of combined antiretroviral therapy (cART) has greatly improved the quality of life of human immunodeficiency virus type 1 (HIV-1)-infected individuals.
Perpetual Nyame, Akihiro Togami, Tomofumi Yoshida, Takuya Masunaga, M.S.T. Monira Begum, Hiromi Terasawa, Nami Monde, Y. Tahara, R. Tanaka, Yuestu Tanaka, Joyce Appiah-Kubi, Wright Ofotsu Amesimeku, Md. Jakir Hossain, Masami Otsuka, Kazuhisa Yoshimura, Terumasa Ikeda, Tomohiro Sawa, Yorifumi Satou, M. Fujita, Yosuke Maeda, Hiroshi Tateishi, Kazuaki Monde   +21 more
semanticscholar   +1 more source