Results 91 to 100 of about 7,006 (230)

Vpu-dependent block to incorporation of GaLV Env into lentiviral vectors [PDF]

, 2010
Background The gibbon ape leukemia virus (GaLV) Env protein mediates entry into a wide range of human cells and is frequently used to pseudotype retroviral vectors.
Ilias Christodoulopoulos, Magali E Droniou-Bonzom, Jill E Oldenburg, Paula M Cannon   +3 more
core   +2 more sources

Ebola Virus Glycoprotein Counteracts BST-2/Tetherin Restriction in a Sequence-Independent Manner That Does Not Require Tetherin Surface Removal [PDF]

Journal of Virology, 2010
ABSTRACT BST-2/tetherin is an interferon-inducible protein that restricts the release of enveloped viruses from the surface of infected cells by physically linking viral and cellular membranes. It is present at both the cell surface and in a perinuclear region, and viral anti-tetherin factors including HIV-1 Vpu and HIV-2 Env have been shown ...
Lisa A, Lopez, Su Jung, Yang, Heiko, Hauser, Colin M, Exline, Kevin G, Haworth, Jill, Oldenburg, Paula M, Cannon   +6 more
openaire   +2 more sources

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.

PLoS Pathogens, 2009
Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts this
Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Madeleine Zufferey, Jeremy Luban, Vincent Piguet   +5 more
doaj   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, Volume 58, Issue 11, November 2025.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

A system for production of defective interfering particles in the absence of infectious influenza A virus

, 2019
Influenza A virus (IAV) infection poses a serious health threat and novel antiviral strategies are needed. Defective interfering particles (DIPs) can be generated in IAV infected cells due to errors of the viral polymerase and may suppress spread of wild
Arora, P., Bdeir, N., Gärtner, S., Hoffmann, M., Pöhlmann, S., Reichl, U., Winkler, M.   +6 more
core   +2 more sources

BST2/Tetherin Enhances Entry of Human Cytomegalovirus

PLoS Pathogens, 2011
Interferon-induced BST2/Tetherin prevents budding of vpu-deficient HIV-1 by tethering mature viral particles to the plasma membrane. BST2 also inhibits release of other enveloped viruses including Ebola virus and Kaposi's sarcoma associated herpesvirus (KSHV), indicating that BST2 is a broadly acting antiviral host protein.
Kasinath Viswanathan, M Shane Smith, Daniel Malouli, Mandana Mansouri, Jay A Nelson, Klaus Früh   +5 more
openaire   +4 more sources

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

Advanced Science, Volume 12, Issue 33, September 4, 2025.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu, Suhui He, Wen Shi, Jinxia Xu, Shiyang Liu, Zexu Yu, Danyue Li, Qiao Jin, Yumeng Wang, Zian Zhang, Qian Lv, Yuanxiang Ge, Yunjie Li, Xinyue Li, Nan Chen, Xinyu Fu, Yang Yang, Fushan Shi   +17 more
wiley   +1 more source

Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses [PDF]

Scientific Reports, 2015
AbstractHuman immunodeficiency virus, a primate lentivirus (PLV), causes AIDS in humans, whereas most PLVs are less or not pathogenic in monkeys. These notions suggest that the co-evolutionary process of PLVs and their hosts associates with viral pathogenicity and therefore, that elucidating the history of virus-host co-evolution is one of the most ...
Takeuchi, Junko S., Ren, Fengrong, Yoshikawa, Rokusuke, Yamada, Eri, Nakano, Yusuke, Kobayashi, Tomoko, Matsuda, Kenta, Izumi, Taisuke, Misawa, Naoko, Shintaku, Yuta, Wetzel, Katherine S., Collman, Ronald G., Tanaka, Hiroshi, Hirsch, Vanessa M., Koyanagi, Yoshio, Sato, Kei   +15 more
openaire   +2 more sources

Cloning and characterization of the antiviral activity of feline Tetherin/BST-2.

PLoS ONE, 2011
Human Tetherin/BST-2 has recently been identified as a cellular antiviral factor that blocks the release of various enveloped viruses. In this study, we cloned a cDNA fragment encoding a feline homolog of Tetherin/BST-2 and characterized the protein ...
Aiko Fukuma, Masumi Abe, Yuko Morikawa, Takayuki Miyazawa, Jiro Yasuda   +4 more
doaj   +1 more source

Vpu binds directly to tetherin and displaces it from nascent virions.

PLoS Pathogens, 2013
Tetherin (Bst2/CD317/HM1.24) is an interferon-induced antiviral host protein that inhibits the release of many enveloped viruses by tethering virions to the cell surface.
Matthew W McNatt, Trinity Zang, Paul D Bieniasz   +2 more
doaj   +1 more source