Results 41 to 50 of about 20,255 (238)
HIV-1 Vpu Disarms Natural Killer Cells [PDF]
Cell Host & Microbe, 2010 Natural killer (NK)-cell killing of virus-infected cells is regulated in part by the engagement of activation and coactivation receptors. In this issue of Cell Host & Microbe, Shah et al. (2010) demonstrate that HIV-1 protects infected cells from NK-cell-mediated killing by hindering NK-cell degranulation through downmodulation of NTB-A coactivation ...
Richard, Jonathan, Cohen, Éric A.
openaire +2 more sources
CD155 on HIV-infected cells is not modulated by HIV-1 Vpu and Nef but synergizes with NKG2D ligands to trigger NK cell lysis of autologous primary HIV-infected cells [PDF]
, 2017 Activation of primary CD4(+) T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)].
Barker, Edward +5 more
core +2 more sources
Journal of Virology, 2021 HIV-1 persists in individuals on antiretroviral therapy (ART) due to the long-lived cellular reservoirs that contain dormant viruses. Recent discoveries of HIV-1-specific broadly neutralizing antibodies (bNabs) targeting HIV-1 Env protein rekindled the ...
Hongbo Gao +7 more
semanticscholar +1 more source
PLoS Pathogens, 2015 HIV-1 Vpu prevents incorporation of tetherin (BST2/ CD317) into budding virions and targets it for ESCRT-dependent endosomal degradation via a clathrin-dependent process. This requires a variant acidic dileucine-sorting motif (ExxxLV) in Vpu.
Tonya Kueck +5 more
doaj +1 more source
Polypeptides inhibit HIV-1 replication by interfering viral Vpu-mediated tetherin degradation
Infectious Medicine, 2023 s: Background: HIV-1 Vpu acts by counteracting the tethering function of tetherin and resulting in the release of HIV-1 virion. Disrupting Vpu-tetherin interactions may provide a promising new target for antiretroviral therapy.
Shuai Chang +6 more
doaj +1 more source
Autonomous real-time surveillance system with distributed IP cameras [PDF]
, 2009 An autonomous Internet Protocol (IP) camera based object tracking and behaviour identification system, capable of running in real-time on an embedded system with limited memory and processing power is presented in this paper.
Aiken, Phil +4 more
core +1 more source
Model vrtulové pohonné jednotky s variabilním úhlem náběhu [PDF]
, 2017 The contribution deals with the mathematical model of the propeller drive unit with variable pitch. The introductory part of the article aims at a general mathematical description of the internal structure of the aircraft propulsion.
Gebauer, Jan, Wagnerová, Renata
core +1 more source
bioRxiv, 2021 HIV-1 Nef and Vpu exert several biological functions that are important for viral immune evasion, release, and replication. Here, we developed a new method allowing simultaneous detection of these accessory proteins in their native form together with ...
Jérémie Prévost +9 more
semanticscholar +1 more source
Vpu and BST2: Still Not There Yet? [PDF]
Frontiers in Microbiology, 2012 Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV type 1 (HIV-1) replication and are widely accepted as "restriction factors." APOBEC3G was identified as a restriction factor that diminishes HIV-1 replication by inducing G-to-A hypermutation in the viral genome, while BST2 has been identified as another ...
Kei eSato +3 more
openaire +3 more sources
Functional conservation and coherence of HIV-1 subtype A Vpu alleles
Scientific Reports, 2017 Functional studies of HIV-1 proteins are normally conducted using lab adapted strains of HIV-1. The extent of those functions in clinical strains is sometimes unknown.
Bizhan Romani +2 more
doaj +1 more source