Results 51 to 60 of about 20,255 (238)
Which World Bank reports are widely read? [PDF]
, 2014 Knowledge is central to development. The World Bank invests about one-quarter of its budget for country services in knowledge products. Still, there is little research about the demand for these knowledge products and how internal knowledge flows affect ...
Doerte Doemeland, James Trevino
core +1 more source
Applied Biochemistry and Biotechnology, 2021 T7 expression system (T7 RNA polymerase / T7 promoter), derived from T7 bacteriophage, is one of the most extensively used protein expression systems, which is also an enabling tool in synthetic biology.
Kun Yan, Jun Li, Wenya Wang, Qiang Li
semanticscholar +1 more source
A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1.
PLoS ONE, 2015 BackgroundPandemic strains of HIV-1 (group M) encode a total of nine structural (gag, pol, env), regulatory (rev, tat) and accessory (vif, vpr, vpu, nef) genes.
Simon M Langer +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 Bone marrow stromal cell antigen 2 (BST-2), also known as CD317 or tetherin, has been identified as a host restriction factor that suppresses the release of enveloped viruses from host cells by physically tethering viral particles to the cell surface ...
Boye Li +9 more
semanticscholar +1 more source
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. [PDF]
, 2019 The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the ...
Guatelli, John +5 more
core +1 more source
Vpu binds directly to tetherin and displaces it from nascent virions.
PLoS Pathogens, 2013 Tetherin (Bst2/CD317/HM1.24) is an interferon-induced antiviral host protein that inhibits the release of many enveloped viruses by tethering virions to the cell surface.
Matthew W McNatt +2 more
doaj +1 more source
HIV-1 Accessory Proteins: Vpu and Vif [PDF]
, 2014 HIV-1 Vif and Vpu are accessory factors involved in late stages of viral replication. Vif regulates viral infectivity by preventing virion incorporation of APOBEC3G and other members of the family of cytidine deaminases, while Vpu causes degradation of CD4 and promotes virus release by functionally inactivating the host factor BST-2.
Amy, Andrew, Klaus, Strebel
openaire +2 more sources
Virology Journal, 2012 Background Unintegrated HIV-1 DNA serves as transcriptionally active templates in HIV-infected cells. Several host factors including NF-κβ enhance HIV-1 transcription.
Emeagwali Nkiruka, Hildreth James EK
doaj +1 more source
HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4+ T Cells
Journal of Virology, 2020 HIV infection modulates the surface expression of Tim-3, but the molecular determinants remain poorly understood. Here, we show that HIV-1 Vpu downregulates Tim-3 from the surface of infected primary CD4+ T cells through its transmembrane domain and ...
Jérémie Prévost +12 more
semanticscholar +1 more source
PLoS Pathogens, 2007 Viral protein U (Vpu) of HIV-1 has two known functions in replication of the virus: degradation of its cellular receptor CD4 and enhancement of viral particle release.
Emilie Estrabaud +8 more
doaj +1 more source