Results 61 to 70 of about 8,539 (222)

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Vpu-dependent block to incorporation of GaLV Env into lentiviral vectors

Retrovirology, 2010
Background The gibbon ape leukemia virus (GaLV) Env protein mediates entry into a wide range of human cells and is frequently used to pseudotype retroviral vectors.
Cannon Paula M, Oldenburg Jill E, Droniou-Bonzom Magali E, Christodoulopoulos Ilias   +3 more
doaj   +1 more source

2011 m. VPU Jaunųjų matematikų olimpiados apžvalga [PDF]

, 2011
The texts and solutions of the VPU young mathematicians olympiad – 2011 are presented.Straipsnyje aptariami 2010 metų VPU jaunųjų matematikų olimpiados uždaviniai ir jų ...
Kaučikas, Algirdas, Jakaitytė, Eglė, Mazėtis, Edmundas   +2 more
core   +1 more source

Approaching Sixfold Chemical Bonding: Metal Dimers MM' Involving Group 4–8 Transition Metals and the Actinides Th–Np. Additive Covalent Radii r6$r_6$

Chemistry – A European Journal, Volume 32, Issue 18, 14 May 2026.
Twelve‐valence‐electron transition metal dimers MM', like diatomic Mo2, can have nearly sixfold bonds. Values of r6$r_6$ for over 20 elements from Sc to Pu are proposed. ABSTRACT A set of additive covalent radii is fitted to a combination of experimental data, accurate ab initio computations, and more approximate DFT MM' bond lengths, R$R$, with 12 ...
Pekka Pyykkö, Michiko Atsumi
wiley   +1 more source

2010 m. VPU jaunųjų matematikų olimpiados apžvalga [PDF]

, 2010
The texts and solutions of the VPU young mathematicians olympiad – 2010 are presented.Straipsnyje aptariami 2010 metų VPU jaunųjų matematikų olimpiados uždaviniai ir jų ...
Kaučikas, Algirdas, Jakaitytė, Eglė, Mazėtis, Edmundas   +2 more
core   +1 more source

A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.

PLoS Pathogens, 2012
The HIV-1 accessory protein Vpu counteracts tetherin (BST-2/CD317) by preventing its incorporation into virions, reducing its surface expression, and ultimately promoting its degradation.
Tonya Kueck, Stuart J D Neil
doaj   +1 more source

Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation.

PLoS ONE, 2013
CD317/tetherin (aka BST2 or HM1.24 antigen) is an interferon inducible membrane protein present in regions of the lipid bilayer enriched in sphingolipids and cholesterol (often termed lipid rafts).
Ruth Rollason, Katie Dunstan, Peter G Billcliff, Paul Bishop, Paul Gleeson, Helen Wise, Paul Digard, George Banting   +7 more
doaj   +1 more source

Sex‐Specific Factors Influencing HIV Infection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Maria Pujantell, Marcus Altfeld
wiley   +1 more source

βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin

Viruses, 2018
The Human immunodeficiency virus-1 (HIV-1) accessory protein Vpu modulates numerous proteins, including the host proteins CD4 and BST-2/tetherin. Vpu interacts with the Skp, Cullin, F-Box (SCF) ubiquitin ligase through interactions with the F-Box protein
Yul Eum Song, Daniel Cyburt, Tiffany M. Lucas, Devon A. Gregory, Terri D. Lyddon, Marc C. Johnson   +5 more
doaj   +1 more source

Differentiable River Routing for End‐to‐End Learning of Hydrological Processes

Journal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 1, February 2026.
Abstract Deep Learning (DL) approaches have shown high accuracy in rainfall runoff modeling. Currently, however, large‐scale DL hydrological simulations at national and global scales still rely on external routing schemes to propagate runoff outputs through river networks, preventing them from leveraging the benefits of end‐to‐end learning of ...
Tristan Hascoet, Victor Pellet, Satoru Oishi, Takemasa Miyoshi   +3 more
wiley   +1 more source