Results 61 to 70 of about 20,255 (238)

Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.

PLoS Pathogens, 2014
The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein ...
Suzanne Pickering, Stephane Hué, Eun-Young Kim, Susheel Reddy, Steven M Wolinsky, Stuart J D Neil   +5 more
doaj   +1 more source

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.

PLoS Pathogens, 2009
Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts this
Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Madeleine Zufferey, Jeremy Luban, Vincent Piguet   +5 more
doaj   +1 more source

In Silico Insights into HIV-1 Vpu-Tetherin Interactions and Its Mutational Counterparts

Medical Sciences, 2019
Tetherin, an interferon-induced host protein encoded by the bone marrow stromal antigen 2 (BST2/CD317/HM1.24) gene, is involved in obstructing the release of many retroviruses and other enveloped viruses by cross-linking the budding virus particles to ...
Patil Sneha, Urmi Shah, Seetharaman Balaji   +2 more
doaj   +1 more source

Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors

Frontiers in Virology, 2022
HIV-1 accessory proteins Nef and Vpu enhance viral pathogenesis through partially overlapping immune evasion activities. Attenuated Nef or Vpu functions have been reported in individuals who display slower disease progression, but few studies have ...
Gisele Umviligihozo, Jaclyn K. Mann, Steven W. Jin, Francis M. Mwimanzi, Hua-Shiuan A. Hsieh, Hanwei Sudderuddin, Guinevere Q. Lee, Helen Byakwaga, Helen Byakwaga, Conrad Muzoora, Peter W. Hunt, Jeff N. Martin, Jessica E. Haberer, Jessica E. Haberer, Etienne Karita, Susan Allen, Eric Hunter, Eric Hunter, Zabrina L. Brumme, Zabrina L. Brumme, Mark A. Brockman, Mark A. Brockman, Mark A. Brockman   +22 more
doaj   +1 more source

Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene.

PLoS ONE, 2012
In different primate lentiviruses, three proteins (Vpu, Env and Nef) have been shown to have anti-tetherin activities. SIVden is a primate lentivirus harbored by a Cercopithecus denti (C. denti) whose genome code for a Vpu gene.
Kristina Nikovics, Marie-Christine Dazza, Michel Ekwalanga, Fabrizio Mammano, François Clavel, Sentob Saragosti   +5 more
doaj   +1 more source

Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking.

PLoS Pathogens, 2009
The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells. The HIV-1 accessory protein Vpu antagonizes this restriction by an unknown mechanism that likely involves the down-
Richard S Mitchell, Chris Katsura, Mark A Skasko, Katie Fitzpatrick, David Lau, Autumn Ruiz, Edward B Stephens, Florence Margottin-Goguet, Richard Benarous, John C Guatelli   +9 more
doaj   +1 more source

Simian Immunodeficiency Virus SIVgsn-99CM71 Vpu Employs Different Amino Acids To Antagonize Human and Greater Spot-Nosed Monkey BST-2

Journal of Virology, 2021
Genes related to survival against life-threating pathogens are important determinants of natural selection in animal evolution. For instance, BST-2, a protein showing broad-spectrum antiviral activity, shows polymorphisms entailing different phenotypes ...
Weitong Yao, K. Strebel, S. Yamaoka, Takeshi Yoshida   +3 more
semanticscholar   +1 more source

Mechanisms underlying HIV-1 Vpu-mediated viral egress [PDF]

Frontiers in Microbiology, 2014
Viruses such as lentiviruses that are responsible for long lasting infections have to evade several levels of cellular immune mechanisms to persist and efficiently disseminate in the host. Over the past decades, much evidence has emerged regarding the major role of accessory proteins of primate lentiviruses, human immunodeficiency virus and simian ...
Roy, Nicolas, Pacini, Grégory, Berlioz-Torrent, Clarisse, Janvier, Katy   +3 more
openaire   +3 more sources

Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein – a genetic, biochemical and biophysical analysis

Virology Journal, 2007
Background The human immunodeficiency virus type 1(HIV-1) is a complex retrovirus and the causative agent of acquired immunodeficiency syndrome (AIDS). The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral
Tanwar Charu, Das Suman R, Hussain Amjad, Jameel Shahid   +3 more
doaj   +1 more source

Enabling Gaia observations of naked-eye stars

, 2014
The ESA Gaia space astrometry mission will perform an all-sky survey of stellar objects complete in the nominal magnitude range G = [6.0 - 20.0]. The stars with G lower than 6.0, i.e.
Kohley, R., L'hermitte, J., Martín-Fleitas, J., Massart, B., Mora, A., Paulet, P., Roy, M. Le, Sahlmann, J.   +7 more
core   +1 more source