Results 31 to 40 of about 8,539 (222)

Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene.

PLoS ONE, 2012
In different primate lentiviruses, three proteins (Vpu, Env and Nef) have been shown to have anti-tetherin activities. SIVden is a primate lentivirus harbored by a Cercopithecus denti (C. denti) whose genome code for a Vpu gene.
Kristina Nikovics, Marie-Christine Dazza, Michel Ekwalanga, Fabrizio Mammano, François Clavel, Sentob Saragosti   +5 more
doaj   +1 more source

Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking.

PLoS Pathogens, 2009
The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells. The HIV-1 accessory protein Vpu antagonizes this restriction by an unknown mechanism that likely involves the down-
Richard S Mitchell, Chris Katsura, Mark A Skasko, Katie Fitzpatrick, David Lau, Autumn Ruiz, Edward B Stephens, Florence Margottin-Goguet, Richard Benarous, John C Guatelli   +9 more
doaj   +1 more source

In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.

PLoS ONE, 2014
The interferon-inducible cellular protein tetherin (CD317/BST-2) inhibits the release of a broad range of enveloped viruses. The HIV-1 accessory protein Vpu enhances virus particle release by counteracting this host restriction factor.
Abdul A Waheed, Nishani D Kuruppu, Kathryn L Felton, Darren D'Souza, Eric O Freed   +4 more
doaj   +1 more source

Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein – a genetic, biochemical and biophysical analysis

Virology Journal, 2007
Background The human immunodeficiency virus type 1(HIV-1) is a complex retrovirus and the causative agent of acquired immunodeficiency syndrome (AIDS). The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral
Tanwar Charu, Das Suman R, Hussain Amjad, Jameel Shahid   +3 more
doaj   +1 more source

Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

Retrovirology, 2010
Background The human immunodeficiency virus type 1 (HIV-1) Vpu protein degrades CD4 and counteracts a restriction factor termed tetherin (CD317; Bst-2) to enhance virion release.
Specht Anke, Iwanski Alicja, Koppensteiner Herwig, Wimmer Peter, Banning Carina, Rajan Devi, Schindler Michael, Sauter Daniel, Dobner Thomas, Kirchhoff Frank   +9 more
doaj   +1 more source

Impedance analysis and single ion channel recordings on pore-suspending lipid bilayers based on highly ordered pore arrays [PDF]

, 2006
Ion channels are one of the main drug targets and are in the focus of various membrane biosensor applications and drug screening assays. The aim of this thesis was to develop and characterize a novel membrane system suspending highly ordered porous ...
Römer, Winfried
core   +1 more source

Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

eLife, 2014
BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Xiaofei Jia, Erin Weber, Andrey Tokarev, Mary Lewinski, Maryan Rizk, Marissa Suarez, John Guatelli, Yong Xiong   +7 more
doaj   +1 more source

Identification of residues in the BST-2 TM domain important for antagonism by HIV-1 Vpu using a gain-of-function approach

Frontiers in Microbiology, 2011
The HIV-1 Vpu protein enhances the release of viral particles from the cell surface in a cell-type specific manner. In the absence of Vpu, nascent virions remain tethered to the cell surface in restricted cell types. Recently, the human host factor BST-2/
Takeshi eYoshida, Sandra eKao, Klaus eStrebel   +2 more
doaj   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Dynamics of HIV-1 assembly and release. [PDF]

, 2009
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic and ...
Kräusslich Hans-Georg, Barbara Müller, William J. Godinez, Bräuchle Christoph, Müller, Barbara, Rohr Karl, Karl Rohr, Godinez, William J., William J Godinez, Lampe Marko, Eils, Roland, Godinez William J., Roland Eils, Rohr, Karl, Lampe, Marko, Ivanchenko Sergey, Lamb, Don C., Don C. Lamb, Marko Lampe, Bräuchle, Christoph, Eils Roland, Lamb Don C., Hans-Georg Kräusslich, Christoph Bräuchle, Kräusslich, Hans-Georg, Sergey Ivanchenko, Ivanchenko, Sergey, Don C Lamb, Müller Barbara   +28 more
core   +2 more sources