Results 31 to 40 of about 20,255 (238)

HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association

bioRxiv, 2023
We report our findings on the assembly of the HIV-1 protein Vpu into soluble oligomers. Vpu is a key HIV-1 protein. It has been considered exclusively a single-pass membrane protein.
Saman Majeed, Lan Dang, M. Islam, Olamide Ishola, P. Borbat, S. Ludtke, Elka R Georgieva   +6 more
semanticscholar   +1 more source

Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells

mBio, 2023
The HIV-1 Vpu protein is expressed late in the virus lifecycle to promote infectious virus production and avoid innate and adaptive immunity. This includes the inhibition of the NF-κB pathway which, when activated, leads to the induction of inflammatory ...
S. Pickering, J. Sumner, C. Kerridge, Marianne R Perera, S. Neil   +4 more
semanticscholar   +1 more source

MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages

mBio, 2023
The type 1 interferon-regulated E3 ubiquitin ligase MARCH1 reduces surface expression of HIV-1 envelope glycoproteins (Env) and their packaging into nascent virions, a condition that restricts viral infectivity.
R. Lodge, Zaikun Xu, Mckenna Eklund, C. Stürzel, F. Kirchhoff, Michel J. Tremblay, T. Hobman, Éric A. Cohen   +7 more
semanticscholar   +1 more source

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

bioRxiv, 2022
Non-neutralizing antibodies (nnAbs) can eliminate HIV-1-infected cells via antibody-dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the RV144 vaccine trial.
Jérémie Prévost, S. Anand, J. Rajashekar, J. Richard, Guillaume Goyette, H. Medjahed, Gabrielle Gendron-Lepage, Hung-Ching Chen, Yao Chen, J. Horwitz, Michael W. Grunst, S. Zolla-Pazner, B. Haynes, D. Burton, R. Flavell, F. Kirchhoff, B. Hahn, Amos B. Smith, M. Pazgier, M. Nussenzweig, Priti Kumar, A. Finzi   +21 more
semanticscholar   +1 more source

Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis

Viruses, 2021
Human immunodeficiency virus (HIV)-1 and HIV-2 originated from cross-species transmission of simian immunodeficiency viruses (SIVs). Most of these transfers resulted in limited spread of these viruses to humans.
Nabab Khan, J. Geiger
semanticscholar   +1 more source

Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C

Frontiers in Immunology, 2022
NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic receptor family,
Sarah Vollmers, A. Lobermeyer, Annika Niehrs, Pia Fittje, D. Indenbirken, Jacqueline Nakel, Sanamjeet Virdi, Sébastien Brias, Timo Trenkner, G. Sauer, S. Peine, G. Behrens, C. Lehmann, A. Meurer, R. Pauli, N. Postel, J. Roider, S. Scholten, C. Spinner, C. Stephan, E. Wolf, C. Wyen, L. Richert, P. Norman, J. Sauter, Alexander H Schmidt, Angelique Hoelzemer, M. Altfeld, C. Körner   +28 more
semanticscholar   +1 more source

The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function [PDF]

Retrovirology, 2013
Abstract Background The acquisition of effective Vpu-mediated anti-tetherin activity to promote virion release following transmission of SIVcpzPtt from central chimpanzees (Pan troglodytes troglodytes) to humans distinguishes pandemic HIV-1 group M strains from non-pandemic group N, O and P viruses and may have been a
Kluge, S. F., Sauter, D., Vogl, M., /Peeters, Martine, Li, Y. Y., Bibollet-Ruche, F., Hahn, B. H., Kirchhoff, F.   +7 more
openaire   +3 more sources

HIV-1 Vpu Promotes Phagocytosis of Infected CD4+ T Cells by Macrophages through Downregulation of CD47

bioRxiv, 2021
Macrophages play critical roles in human immunodeficiency virus (HIV) transmission, viral spread early in infection, and as a reservoir of virus. Selective capture and engulfment of HIV-1-infected T cells was shown to drive efficient macrophage infection,
Lijun Cong, Scott M. Sugden, P. Leclair, C. Lim, T. Pham, É. Cohen   +5 more
semanticscholar   +1 more source

HLA-C Downmodulation by HIV-1 Vpu [PDF]

Cell Host & Microbe, 2016
It is widely held that HIV-1 Nef downmodulates HLA-A and -B to protect infected cells from CD8(+) T cells but leaves HLA-C on the cell surface to inhibit NK cells. In this issue of Cell Host & Microbe, Apps et al. (2016) revise this model by showing that the Vpu protein of primary HIV-1 isolates downmodulate HLA-C.
Edward, Barker, David T, Evans
openaire   +2 more sources

This Bud's for Vpu [PDF]

Cell Host & Microbe, 2009
Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses.
openaire   +2 more sources