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The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation [PDF]

Frontiers in Immunology, 2021
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands.
Hendrik J. P. van der Zande, Dominik Nitsche, Laura Schlautmann, Bruno Guigas, Sven Burgdorf   +4 more
doaj   +6 more sources

Mannose Ligands for Mannose Receptor Targeting [PDF]

International Journal of Molecular Sciences
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit
Rosana Ribic, Martina Šrajer Gajdosik, Marija Paurevic   +2 more
exaly   +3 more sources

Selective clearance of monoclonal antibodies via the mannose receptor is dependent on glycan pairing [PDF]

Scientific Reports
The pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs) are influenced by N-glycosylation, a critical quality attribute (CQA) that affects serum half-life and receptor interactions.
Julia Baumeister, Maximilian Meudt, Wei Wei, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Lin-Zhi Chen, Fabian Higel   +8 more
doaj   +2 more sources

Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition [PDF]

Virulence
The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear.
Hong Zhang, Tao Zhu, Wenchun Xu, Bichen Liu, Kaifeng Wu, Yibing Yin, Xuemei Zhang   +6 more
doaj   +2 more sources

Mannose receptor contributes to preferential oligomannosidic glycoform clearance in a murine pharmacokinetics model [PDF]

mAbs
The pharmacokinetic profile of therapeutic antibodies, which affects the dosing frequency, efficacy, and cost of the products, is influenced by several molecular features, including N- glycosylation. While the accelerated clearance of antibodies carrying
David Falck, Steinar Gijze, Anna M. Wasynczuk, Sebastian Malik, Aline Tridon, Martin Lechmann, Manfred Wuhrer, Dietmar Reusch   +7 more
doaj   +2 more sources

Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing [PDF]

mAbs
During the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions.
Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel   +7 more
doaj   +2 more sources

Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2021
Sven Burgdorf, Anna Zawistowska-Deniziak, Jonas Schulte-Schrepping   +2 more
exaly   +2 more sources

Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis

BMC Pediatrics, 2021
Introduction The differentiation between systemic inflammatory response syndrome and sepsis is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy.
Noha A. Hassuna, Ebtesam Elgezawy, Suzan O. Mousa, Reem A. AbdelAziz, Reham A. Ibrahem, Wafaa Yousif Abdel Wahed, Khalid A. Nasif, Enas M. Hefzy   +7 more
doaj   +1 more source

Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. [PDF]

PLoS ONE, 2011
Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and CD206
Denarda Dangaj, Karen L Abbott, Ananda Mookerjee, Aizhi Zhao, Pamela S Kirby, Raphael Sandaltzopoulos, Daniel J Powell, Antonin Lamazière, Don L Siegel, Claude Wolf, Nathalie Scholler   +10 more
doaj   +1 more source

Macrophage-Targeted Punicalagin Nanoengineering to Alleviate Methotrexate-Induced Neutropenia: A Molecular Docking, DFT, and MD Simulation Analysis

Molecules, 2022
Punicalagin is the most bioactive pomegranate polyphenol with high antioxidant and free-radical scavenging activity and can potentially cure different ailments related to the cardiovascular system.
Ritu Karwasra, Shaban Ahmad, Nagmi Bano, Sahar Qazi, Khalid Raza, Surender Singh, Saurabh Varma   +6 more
doaj   +1 more source