Horizontal gene transfer contributed to the evolution of extracellular surface structures [PDF]
, 2012 The single-cell layered ectoderm of the fresh water polyp Hydra fulfills the function of an epidermis by protecting the animals from the surrounding medium.
Altstätter, Johannes +13 more
core +1 more source
Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]
, 2018 Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J +5 more
core +6 more sources
The mannose receptor mediates dengue virus infection of macrophages. [PDF]
PLoS Pathogens, 2008 Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans. To our knowledge, we show for the first time that the MØ mannose receptor (MR) binds
Joanna L Miller +6 more
doaj +1 more source
Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors [PDF]
Proceedings of the National Academy of Sciences, 2006 Enzyme replacement therapy (ERT) is available for several lysosomal storage diseases. Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).
William S, Sly +7 more
openaire +2 more sources
Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]
, 2018 This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R +5 more
core +1 more source
Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits [PDF]
, 1991 The clustering of plasma membrane receptors in clathrin-coated pits depends on determinants within their cytoplasmic domains. In several cases, individual tyrosine residues were shown to be necessary for rapid internalization.
Fuhrer, C., Geffen, I., Spiess, M.
core +3 more sources
The Mannose Receptor in Regulation of Helminth-Mediated Host Immunity
Frontiers in Immunology, 2017 Infection with parasitic helminths affects humanity and animal welfare. Parasitic helminths have the capacity to modulate host immune responses to promote their survival in infected hosts, often for a long time leading to chronic infections.
Irma van Die, Richard D. Cummings
doaj +1 more source
Frontiers in Plant Science, 2021 Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose
Naphatsamon Uthailak +7 more
doaj +1 more source
Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells
Molecules, 2020 Recently, gold nanoparticles (Au NPs) have been used to study the treatment of malignant tumors due to their higher biocompatibility and lesser toxicity.
Han-Chen Lin +5 more
doaj +1 more source
The Third Dimension of Reading the Sugar Code by Lectins [PDF]
, 2013 Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
André, Sabine +2 more
core +3 more sources