Results 11 to 20 of about 1,345,412 (243)

Mannose receptor-mediated gene delivery into antigen presenting dendritic cells

, 2002
Dendritic cells are professional antigen presenting cells and are unique in their ability to prime naive T cells. Gene modification of dendritic cells is of particular interest for immunotherapy of diseases where the immune system has failed or is ...
Zenke, Martin, Diebold, Sandra, Plank, Christian, Wagner, Ernst, Cotten, Matt   +4 more
core   +7 more sources

Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature

Revista da Sociedade Brasileira de Medicina Tropical, 2021
We describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the
Dewton de Moraes Vasconcelos, Dalton Luís Bertolini, Maurício Domingues Ferreira   +2 more
doaj   +1 more source

Mannosylation of virus-like particles enhances internalization by antigen presenting cells. [PDF]

PLoS ONE, 2014
Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses.
Farah Al-Barwani, Sarah L Young, Margaret A Baird, David S Larsen, Vernon K Ward   +4 more
doaj   +1 more source

Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

Nature Communications, 2021
Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.
Huan Cao, Aristotelis Antonopoulos, Sadie Henderson, Heather Wassall, John Brewin, Alanna Masson, Jenna Shepherd, Gabriela Konieczny, Bhinal Patel, Maria-Louise Williams, Adam Davie, Megan A. Forrester, Lindsay Hall, Beverley Minter, Dimitris Tampakis, Michael Moss, Charlotte Lennon, Wendy Pickford, Lars Erwig, Beverley Robertson, Anne Dell, Gordon D. Brown, Heather M. Wilson, David C. Rees, Stuart M. Haslam, J. Alexandra Rowe, Robert N. Barker, Mark A. Vickers   +27 more
doaj   +1 more source

Evolution of an expanded mannose receptor gene family. [PDF]

PLoS ONE, 2014
Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B.
Karen Staines, Lawrence G Hunt, John R Young, Colin Butter   +3 more
doaj   +1 more source

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives

Cells, 2021
Betacoronaviruses, responsible for the “Severe Acute Respiratory Syndrome” (SARS) and the “Middle East Respiratory Syndrome” (MERS), use the spikes protruding from the virion envelope to attach and subsequently infect the host cells.
Annick Barre, Els J. M. Van Damme, Mathias Simplicien, Sophie Le Poder, Bernard Klonjkowski, Hervé Benoist, David Peyrade, Pierre Rougé   +7 more
doaj   +1 more source

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Kiess, W., Kolb, H. J., Funk, B., Kessler, U., Hansmann, A.   +5 more
core   +1 more source

Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier. [PDF]

PLoS ONE, 2012
HIV-1 circulates both as free virus and within immune cells, with the level of free virus being predictive of clinical course. Both forms of HIV-1 cross the blood-brain barrier (BBB) and much progress has been made in understanding the mechanisms by ...
Shinya Dohgu, Jan S Ryerse, Sandra M Robinson, William A Banks   +3 more
doaj   +1 more source

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Guse, Andreas H., Kessler, Ulrike, Funk, Barbara, Gercken, Günther, A. H. Guse, Kiess, Wieland   +6 more
core   +2 more sources

Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds [PDF]

, 2013
This work was supported by a Wellcome Trust award to TMG.Mucopolysaccharidosis (MPS) I is a lysosomal storage disease caused by a deficiency of α-L-iduronidase (IDUA) (EC 3.2.1.76); enzyme replacement therapy is the conventional treatment for this ...
Brooks, Doug, Gloster, Tracey M., Vocadlo, D.J., Brooks, D., Kolarich, Daniel, Kermode, Allison R, Kermode, Allison R., Haselhorst, T., Qian, Y., Gloster, Tracey M, Qian, Yi, Gloster, Tracey, Kolarich, D., Haselhorst, Thomas, Packer, N.H., Pierce, Owen, He, X., von Itzstein, Mark, Gloster, T.M., Packer, Nicolle H., He, Xu, Pierce, O., Packer, Nicolle H, Vocadlo, David J, von Itzstein, M., Kermode, A.R., Vocadlo, David J.   +26 more
core   +1 more source