Results 11 to 20 of about 135,703 (297)

The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation. [PDF]

Front Immunol, 2021
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands.
van der Zande HJP, Nitsche D, Schlautmann L, Guigas B, Burgdorf S.   +4 more
europepmc   +4 more sources

Mannose Ligands for Mannose Receptor Targeting. [PDF]

Int J Mol Sci
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides.
Paurević M, Šrajer Gajdošik M, Ribić R.   +2 more
europepmc   +5 more sources

Selective clearance of monoclonal antibodies via the mannose receptor is dependent on glycan pairing. [PDF]

Sci Rep
The pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs) are influenced by N-glycosylation, a critical quality attribute (CQA) that affects serum half-life and receptor interactions.
Baumeister J, Meudt M, Wei W, Ebert S, Rosenau F, Mizaikoff B, Blech M, Chen LZ, Higel F.   +8 more
europepmc   +2 more sources

Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition. [PDF]

Virulence
The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear.
Zhang H, Zhu T, Xu W, Liu B, Wu K, Yin Y, Zhang X.   +6 more
europepmc   +2 more sources

Mannose receptor contributes to preferential oligomannosidic glycoform clearance in a murine pharmacokinetics model. [PDF]

MAbs
The pharmacokinetic profile of therapeutic antibodies, which affects the dosing frequency, efficacy, and cost of the products, is influenced by several molecular features, including N- glycosylation. While the accelerated clearance of antibodies carrying
Falck D, Gijze S, Wasynczuk AM, Malik S, Tridon A, Lechmann M, Wuhrer M, Reusch D.   +7 more
europepmc   +2 more sources

Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing. [PDF]

MAbs
During the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions.
Baumeister J, Meudt M, Ebert S, Rosenau F, Mizaikoff B, Blech M, Aertker KMJ, Higel F.   +7 more
europepmc   +2 more sources

Evolution of an expanded mannose receptor gene family. [PDF]

PLoS ONE, 2014
Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B.
Karen Staines, Lawrence G Hunt, John R Young, Colin Butter   +3 more
doaj   +4 more sources

Lectin-like bacteriocins from pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor [PDF]

, 2014
Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species ...
A Hviid, A Molinaro, AC Graham, AD Vinion-Dubiel, AHA Parret, AHA Parret, AJ McCoy, Aleksander W. Roszak, AM Abdel-Mawgoud, AW Schuttelkopf, Brian Smith, C Kleanthous, C Manichanh, CL Brown, CL Ng, D Franke, D Walker, Daniel Walker, DI Svergun, E Cascales, E Kurimoto, EJM Van Damme, F Gorrec, F Long, G Gorkiewicz, G Hester, G Kurisu, GN Murshudov, GR Vasta, Guy Tran Van Nhieu, HL Rocchetta, Inokentijs Josts, J Henao-Mejia, J Qin, JAM Fyfe, JB Lyczak, Joel Milner, JS Lam, JU Scher, K Smith, K Zeth, Kai I. Waløen, KC Carroll, KH Caffall, L Holm, L Stewart, Laura C. McCaughey, M Ramm, M Rivera, M Shimokawa, M-F Incardona, MA Jacobs, MB Kozin, ME Spehlmann, MGK Ghequire, MGK Ghequire, MGK Ghequire, MJ Claesson, N Sharon, Nicholas P. Tucker, NR Chandra, Olwyn Byron, P Emsley, PD Adams, PV Konarev, R Grinter, R Grinter, RA Laskowski, Rhys Grinter, Richard J. Cogdell, S Mori, Sharon Kelly, SY Shaw, T Ogawa, Tom Evans, V Ovod, VB Chen, VV Ovod, VV Volkov, WF Vranken, Y Hao, Y Michel-Briand, YA Knirel   +82 more
core   +7 more sources

Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. [PDF]

PLoS ONE, 2011
Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and CD206
Denarda Dangaj, Karen L Abbott, Ananda Mookerjee, Aizhi Zhao, Pamela S Kirby, Raphael Sandaltzopoulos, Daniel J Powell, Antonin Lamazière, Don L Siegel, Claude Wolf, Nathalie Scholler   +10 more
doaj   +1 more source

Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis

BMC Pediatrics, 2021
Introduction The differentiation between systemic inflammatory response syndrome and sepsis is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy.
Noha A. Hassuna, Ebtesam Elgezawy, Suzan O. Mousa, Reem A. AbdelAziz, Reham A. Ibrahem, Wafaa Yousif Abdel Wahed, Khalid A. Nasif, Enas M. Hefzy   +7 more
doaj   +1 more source