Results 51 to 60 of about 5,014,214 (288)

HIV-1 Vif: A guardian of the virus that opens up a new era in the research field of restriction factors

Frontiers in Microbiology, 2013
The research on Vif protein had started in late 80s right after HIV-1 was cloned, and the function of Vif had been a mystery for a long time. However, the research on Vif has finally lead to the identification of APOBEC3G, which opens up the new era in ...
Akifumi eTakaori-Kondo, Keisuke eShindo
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Retroviral Restriction Factor TRIM5α Is a Trimer [PDF]

Journal of Virology, 2005
ABSTRACTThe retrovirus restriction factor TRIM5α targets the viral capsid soon after entry. Here we show that the TRIM5α protein oligomerizes into trimers. The TRIM5α coiled-coil and B30.2(SPRY) domains make important contributions to the formation and/or stability of the trimers. A functionally defective TRIM5α mutant with the RING and B-box 2 domains
Claudia C, Mische, Hassan, Javanbakht, Byeongwoon, Song, Felipe, Diaz-Griffero, Matthew, Stremlau, Bettina, Strack, Zhihai, Si, Joseph, Sodroski   +7 more
openaire   +2 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

ESCRT factors restrict mycobacterial growth [PDF]

Proceedings of the National Academy of Sciences, 2008
Nearly 1.7 billion people are infected with Mycobacterium tuberculosis . Its ability to survive intracellularly is thought to be central to its success as a pathogen, but how it does this is poorly understood.
Jennifer A, Philips, Maura C, Porto, Hui, Wang, Eric J, Rubin, Norbert, Perrimon   +4 more
openaire   +2 more sources

B-Cell Lymphoma 6 (BCL6) Is a Host Restriction Factor That Can Suppress HBV Gene Expression and Modulate Immune Responses

Frontiers in Microbiology, 2019
Hepatitis B virus (HBV) infection causes acute and chronic liver inflammation. Recent studies have demonstrated that some viral antigens can suppress host innate and adaptive immunity, and thus lead to HBV liver persistency. However, the cellular factors
Chun-Ta Lin, Chun-Ta Lin, Yue-Ting Hsieh, Yeng-Jey Yang, Shih-Hui Chen, Cheng-Hsuan Wu, Lih-Hwa Hwang   +6 more
doaj   +1 more source

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages

eLife, 2020
HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary conservation of Vpr suggests an important yet poorly understood role for macrophages in HIV pathogenesis.
Jay Lubow, Maria C Virgilio, Madeline Merlino, David R Collins, Michael Mashiba, Brian G Peterson, Zana Lukic, Mark M Painter, Francisco Gomez-Rivera, Valeri Terry, Gretchen Zimmerman, Kathleen L Collins   +11 more
doaj   +1 more source

Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I

Viruses, 2023
The seven human APOBEC3 enzymes (APOBEC3A through H, excluding E) are host restriction factors. Most of the APOBEC3 enzymes can restrict HIV-1 replication with different efficiencies. The HIV-1 Vif protein combats APOBEC3-mediated restriction by inducing
Maria Yousefi, Arun Kumar Annan Sudarsan, Amit Gaba, Linda Chelico   +3 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

eLife, 2016
Restriction factors and pattern recognition receptors are important components of intrinsic cellular defenses against viral infection. Mammalian TRIM5α proteins are restriction factors and receptors that target the capsid cores of retroviruses and ...
Jonathan M Wagner, Marcin D Roganowicz, Katarzyna Skorupka, Steven L Alam, Devin Christensen, Ginna Doss, Yueping Wan, Gabriel A Frank, Barbie K Ganser-Pornillos, Wesley I Sundquist, Owen Pornillos   +10 more
doaj   +1 more source