Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Interpretation Approaches For Biblical Apocalyptic Literature: An Evaluation
, 2020 Emmanuel Foster Asamoah
openalex +2 more sources
The Death of Tragedy: The Form of God in Paul’s \u3cem\u3eCarmen Christi\u3c/em\u3e and Euripides’ Bacchae [PDF]
, 2018 Scholarship on Phil 2:6–11 has long wrestled with the question of “interpretive staging.” While acknowledging that Jewish sapiential and apocalyptic literature as well as Roman apotheosis narratives provide important matrices for the hymn, the following ...
Cover, Michael
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
“When the Sun is Shrouded in Darkness and the Stars are Dimmed” (Qurʾan 81:1–2). Imagery, Rhetoric and Doctrinal Instruction in Muslim Apocalyptic Literature [PDF]
, 2020 Sebastian Günther
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Wittgenstein and the Possibility of Religious Belief [PDF]
, 2003 Contemporary philosophers of religion delimiting their field\ud often distinguish between belief in and belief that, and then\ud focus on the latter as more pertinent to a philosophical\ud investigation of religious belief.
Sayre, Patricia
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
eTropic: electronic journal of studies in the tropics, 2016 In order to better understand and respond to the tropics as part of the global environment, we need to accept the unique features of the regional weather, such as cyclones, and be prepared to embrace their larger meaning for life in the tropics.
Chrystopher Spicer
doaj