Results 111 to 120 of about 58,439 (301)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The story of Noah: violent exclusionary apocaplytic is (not) good to think [PDF]
, 2008 Genesis 6-9; Festschrift in honour of Erwin Buck. Rev fr paper presented at the Waterloo Lutheran Seminary, 19 S 2007, Hope Lutheran Church in Calgary, and All Saints Anglican Church in ...
Greifenhagen, F. V.
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Hope Deferred: Post-Apocalyptic Fiction as Anti-Utopia
BetweenThis paper explores contemporary post-apocalyptic narratives as cultural metaphors reflecting anxieties about societal collapse, environmental crisis, and the future.
Rachele Cinerari
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
James Nayler and the Lamb\u27s War
, 2015 James Nayler was perhaps the most articulate theologian and political spokesman of the earliest Quaker movement. He was part of a West Yorkshire group of radicals who added revolutionary impetus to George Fox\u27s apocalyptic preaching of Christ\u27s ...
Gwyn, Douglas
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The celestial city brought down to earth : Dmitrij Cernákov's interpretation of Rimskij-Korsakov's opera the invisible city of Kitež and the Maiden Fevronia [PDF]
, 2017 Rimsky-Korsakov's penultimate opera is tied to the symbolist movement in fin de siècle Russia. Although the composer did not intend it as a mystical work in the wake of Wagner's Parsifal, his symbolist collaborators invested much symbolist thinking in ...
Maes, Francis
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source