Results 111 to 120 of about 174,340 (311)

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

''Αλλαγή εννοιών στην ιστορία της τεχνολογίας: Η περίπτωση των εννοιών ''ήπιες'', ''εναλλακτικές'' και ''ανανεώσιμες'' ''μορφές'' ή ''πηγές'' ενέργειας.''

, 2016
Η εννοιολογική αλλαγή και εξέλιξη των εννοιών ''ήπιες'', ''εναλλακτικές'' και ''ανανεώσιμες'' ''μορφές'' ή ''πηγές'' ενέργειας όπως εντοπίζεται σε τεχνικά συγγράμματα και περιοδικά, συνέδρια του Ινστιτούτου Ηλιακής Τεχνολογίας και εφημερίδες.
openaire   +1 more source

Το περιοδικό του Ε.Ι.Ρ. ''Ραδιοπρόγραμμα'' (1939-1955)

, 2021
Η παρούσα διπλωματική εργασία παρακολουθεί τη δημιουργία και την εξέλιξη της του περιοδικού του Εθνικού Ιδρύματος Ραδιοφωνίας Εβδομαδιαίον Πρόγραμμα και στην συνέχεια Ραδιοπρόγραμμα, από την πρώτη κυκλοφορία του το 1939 έως και την αλλαγή της φυσιογνωμίας του το 1955.
openaire   +1 more source

Engineered TIGIT‐Blockade Membrane Vesicles Synergize with Microwave Ablation to Mediate Liver Metastases Eradication

Advanced Science, EarlyView.
Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. This study develops engineered cell membrane vesicles to specifically target the transition zone of MWA for liver metastases. This strategy can inhibit VEGF‐mediated immunosuppression, block CD155/TIGIT signaling
Shaoyue Li, Weichen Xu, Yuting Shen, Xuexia Shan, Jiawei Sun, Shisi Ding, Xiaodong Hou, Shaoning Zhang, Zhiyuan Niu, Taixia Wang, Xin Guan, Xiao Li, Weiwei Ren, Dou Du, Huixiong Xu, Wenwen Yue, Liping Sun   +16 more
wiley   +1 more source

Knowledge means 'all', belief means 'most'

, 2012
We introduce a bimodal epistemic logic intended to capture knowledge as truth in all epistemically alternative states and belief as a generalized 'majority' quantifier, interpreted as truth in many (a 'majority' of the) epistemically alternative states.
Askounis, D., Koutras, C.D., Zikos, Y.
openaire   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

APOE suppresses osteosarcoma by modulating ferroptosis through the mTOR/Stat3 signaling pathway

Archives of Medical Science
Introduction Osteosarcoma (OS) is a highly malignant bone tumor with limited treatment options. The role of apolipoprotein E (APOE) in OS remains unclear.
Xiangyang Cheng, Chong Bian, Yiming Zhang, Huijie Gu, Guangnan Chen, Liang Wu   +5 more
doaj   +1 more source