Results 191 to 200 of about 95,854 (268)

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, EarlyView.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease. [PDF]

Nat Aging
Lu L, Pichet Binette A, Hristovska I, Janelidze S, Smets B, Cumplido-Mayoral I, Vasanthakumar A, Milkovich B, Global Neurodegeneration Proteomics Consortium (GNPC), An L, Ossenkoppele R, Krish V, Imam F, Palmqvist S, Vogel JW, Stomrud E, Hansson O, Mattsson-Carlgren N.   +17 more
europepmc   +1 more source

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

PACAP and Maxadilan (PAC1 Agonist) Influence Plaque Progression, Migratory Ability, and Mitochondrial Morphology and Dynamics in Vascular Smooth Muscle Cells. [PDF]

Cells
Brauschke J, Schütz LM, Bonaterra GA, Kinscherf R, Schwarz A.   +4 more
europepmc   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

APOE ε4 and amyloid status moderate the associations between sleep, physical activity, and tau-PET burden in cognitively unimpaired older adults. [PDF]

Alzheimers Dement
Callow DD, Rani N, Smith JC, Soldan A, Pettigrew C, Spira AP, Albert M, Bakker A, BIOCARD Research Team.   +8 more
europepmc   +1 more source

Refining the Genetic Contribution to Type 2 Diabetes Subtypes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Type 2 diabetes (T2D) is a complex and highly heterogeneous disease driven in part by genetic predisposition and can be stratified into clinical subgroups to aid disease management. We recently grouped T2D subjects in the Qatar Biobank (QBB) cohort into Severe Insulin‐Deficient Diabetes (SIDD), Severe Insulin‐Resistant Diabetes ...
Nayra M. Al‐Thani, Salman M. Toor, Umm‐Kulthum Ismail Umlai, Usama Aliyu, Karsten Suhre, Omar M. E. Albagha   +5 more
wiley   +1 more source

Depressive symptoms as a risk factor or prodrome of dementia: multi-state cognitive transitions modified by age and polygenic risk. [PDF]

J Prev Alzheimers Dis
Ren Z, Zhang R, Guo S, Zhao Y, Liu J, Zheng X.   +5 more
europepmc   +1 more source

Heat shock protein 72 attenuates atherosclerosis in apolipoprotein E‐deficient mice

Journal of Diabetes Investigation, EarlyView.
Heat shock (HS) + mild electrical stimulation (MES)‐induced heat shock protein (HSP)72 expression prevents atherogenesis in HSP72+/+/ApoE−/− mice. HS + MES‐induced HSP72 expression reduces macrophage infiltration, oxidative stress, JNK activity, and MCP‐1 expression, and alters macrophage polarity from M1 to M2.
Rintaro Yoshizumi, Tatsuya Kondo, Takuro Watanabe, Nobukazu Miyakawa, Sayaka Kitano, Mary Ann Suico, Miki Sato, Masaji Sakaguchi, Motoyuki Igata, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki, Naoto Kubota   +12 more
wiley   +1 more source