Results 161 to 170 of about 95,989 (269)

Immune dysregulation in the prostates of C57BL/6Aire−/− mice mirrors that seen in human benign prostatic hyperplasia

The Journal of Pathology, EarlyView.
Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman, Meaghan M Broman, Harish Kothandaraman, Gregory M Cresswell, Gada D Awdalkreem, Dilinaer Wusiman, Andree K Kolliegbo, Alexander P Glaser, Brian T Helfand, Renee E Vickman, Jiang Yang, Simon W Hayward, Timothy L Ratliff   +12 more
wiley   +1 more source

Effects of age and APOE ϵ4 genotype on the relationship between pulse pressure and executive function in older adults without dementia. [PDF]

J Int Neuropsychol Soc
Quiring ML, Edwards L, Bangen KJ, Ho EH, Carlsson CM, Galasko D, Weintraub S, Gershon R, Salmon DP.   +8 more
europepmc   +1 more source

'Authenticity' and 'Inauthenticity' in Sneaker Culture

Japanese Review of Cultural Anthropology, 2019
openaire   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

Small, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu, Yun‐Hua Xu, Dan Peng, Qi Tan, Jun‐Lin Jiang, Sheng‐Dan Nie, Shan Wang   +6 more
wiley   +1 more source

The physiological effects of APOE genotype in healthy young/middle-aged individuals. [PDF]

Biol Rev Camb Philos Soc
de Leeuw SM, Emrani S, Putter J, Nuriel T.   +3 more
europepmc   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Redox status of apolipoprotein E in cerebrospinal fluid: a mechanistically informative biomarker for central nervous system disorders. [PDF]

Biosci Rep
Uematsu Y, Iinuma W, Shimizu R, Matsuura H, Yoshinaga T, Yazaki M, Yamauchi K.   +6 more
europepmc   +1 more source

Alcohol consumption and cognitive function: A systematic review and dose–response meta‐analysis of 20 cohort studies

Addiction, EarlyView.
Abstract Background and aims Amid ongoing debate on whether low‐to‐moderate alcohol consumption reduces cardiovascular risk, studies examining the association between alcohol consumption and cognitive function have reported inconsistent results. To quantitatively assess this association, we conducted a dose–response meta‐analysis of cohort studies ...
Sooyeun Choi, Youjin Je
wiley   +1 more source

Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease. [PDF]

EBioMedicine
O'Brien EK, Cox T, Fernandez S, Bourgeat P, Porter T, Goudey B, Doecke JD, Masters CL, Fripp J, Nho K, Villemagne VL, Cruchaga C, Rowe CC, Saykin AJ, Doré V, Laws SM.   +15 more
europepmc   +1 more source