Results 81 to 90 of about 95,989 (269)

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, EarlyView.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

Apolipoprotein E: A Potential Prognostic and Diagnostic Biomarker for Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Yuxia Li, Ruijiao Lu, Xieyidai Abuduhailili, Yangchun Feng Department of Clinical Laboratory Center, Cancer Hospital Affiliated to Xinjiang Medical University, Urumqi, 830000, People’s Republic of ChinaCorrespondence: Yangchun Feng, Email paopao1987123 ...
Li Y, Lu R, Abuduhailili X, Feng Y
doaj  

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Statükoculuk'tan ''Çok Yönlü Dış Politika'ya'': ''Komşularla Sıfır Sorun'' değerlendirmesi

, 2012
Türk dış politikası cumhuriyetin kurulmasından itibaren genel olarak üç temel politika üzerine kurulmuştur. Bunlar `Statükocu', `Batıcı' ve `Güvenlikçi' yaklaşımlar olmuştur. Cumhuriyetin kuruluş aşamasında hem Türkiye'nin içinde bulunduğu koşullar hem de dünya konjonktürü bu politikaların yürütülmesinde belirleyici olmuştur ...
openaire   +1 more source

Clinical Significance of PD‐L1 and HLA Expression in Esophageal Squamous Cell Carcinoma in Response to Immunotherapy

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated immune‐related biomarkers in esophageal squamous cell carcinoma treated with immune checkpoint inhibitors after postoperative recurrence. PD‐L1 expression in tumor‐associated macrophages and tumor cells, together with HLA class I downregulation and HLA‐DR expression, were associated with favorable responses to immunotherapy.
Kosuke Kanemitsu, Yoshiyuki Tagayasu, Yoshihiro Komohara, Cheng Pan, Rin Yamada, Yukio Fujiwara, Kazuto Harada, Keisuke Kosumi, Yoshifumi Baba, Masaaki Iwatsuki   +9 more
wiley   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

''Η ηθικοπολιτική ύπαρξη των Μ.Κ.Ο.''

, 2022
Στην παρούσα έρευνα θα επιχειρήσουμε, με σημείο εκκίνησης την ιστορική αναδρομή στη σύσταση των Μη Κυβερνητικών Οργανώσεων, να θέσουμε ως αντικείμενο συζήτησης τη φιλοσοφική αντίληψη του ωφελιμισμού και της πρακτικής της εφαρμογής στις ΜΚΟ. Έτσι, αρχής γενομένης από την ανάλυση του τρόπου και των βασικών αρχών μέσω των οποίων οι εν λόγω οργανώσεις ...
openaire   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

APOE suppresses osteosarcoma by modulating ferroptosis through the mTOR/Stat3 signaling pathway

Archives of Medical Science
Introduction Osteosarcoma (OS) is a highly malignant bone tumor with limited treatment options. The role of apolipoprotein E (APOE) in OS remains unclear.
Xiangyang Cheng, Chong Bian, Yiming Zhang, Huijie Gu, Guangnan Chen, Liang Wu   +5 more
doaj   +1 more source

Assessment of Genetic Correlations Between Tobacco or Alcohol Use and Neurodegenerative Diseases Using East Asian Genetic Ancestry Genome‐Wide Association Study Results

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent late‐onset neurodegenerative diseases worldwide. Both are influenced in part by genetic factors and are currently incurable. Tobacco and alcohol, the two most common substances used among the general adult population, are potential AD/PD risk factors and are also ...
Linda Wang, Wiame Belbellaj, Frida Lona‐Durazo, Sarah A. Gagliano Taliun   +3 more
wiley   +1 more source