Results 121 to 130 of about 95,989 (269)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Apolipoprotein E Gene ϵ4 Allele is Associated with Atherosclerosis in Multiple Vascular Beds

International Journal of General Medicine
Youni Lin, Min Yang, Qifeng Liu, Yufu Cai, Zhouhua Zhang, Chongfei Xu, Ming Luo Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou, People’s Republic of ChinaCorrespondence: Youni Lin, Center for Cardiovascular Diseases, Meizhou ...
Lin Y, Yang M, Liu Q, Cai Y, Zhang Z, Xu C, Luo M   +6 more
doaj  

APOE-ε4 moderates the association between diet quality and executive function in middle-aged women at increased risk for Alzheimer's disease. [PDF]

J Nutr Sci
Wessinger CM, Park KS, DuBois SL, Wideman L, Armstrong BD, Vance JC, Kibildis SW, Som-Pimpong H, Etnier JL.   +8 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition. [PDF]

MedComm (2020)
Frosina M, Maurotti S, Castagna A, Montalcini T, Pujia A, Tirinato L.   +5 more
europepmc   +1 more source

'Quantum mechanics' and 'scientific explanation' an explanatory strategy aiming at providing 'understanding'

, 2008
Empirical studies persistently indicate that the usual explanatory strategies used in quantum mechanics (QM) instruction fail, in general, to yield understanding. In this study, we propose an instructional intervention, which: (a) incorporates into its subject matter a critical comparison of QM scientific content with the fundamental epistemological ...
openaire   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses. [PDF]

Alzheimers Dement
Zeng Y, Cook N, Yang C, Sivasankaran SK, Fujita M, Gardell ZA, Le Guen Y, Shigemizu D, Ozaki K, Morizono T, Hara N, Miyashita A, Ikeuchi T, Pottier C, Cruchaga C, Napolioni V, Corces MR, Menon V, Greicius MD, Belloy ME.   +19 more
europepmc   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE^-/- mice via regulating estrogen receptor α. [PDF]

Chin Med
Chen L, Shi JH, Ma XJ, Chai H, Wei KK, Yang Z, Tan Y, Huang HB, Shi DZ, Qu H.   +9 more
europepmc   +1 more source