Results 181 to 190 of about 174,900 (290)

Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux [PDF]

, 2018
Jeong, Se-Jin, Jung, In-hyuk
core   +1 more source

Accelerating Medicines Partnership® Parkinson's Disease Proteomics: A Comprehensive Resource for Advancing Parkinson's Disease Research

Movement Disorders, EarlyView.
Abstract Background Recent advances in proteomic profiling have enabled its use as a powerful approach in elucidating molecular mechanisms underlying Parkinson's disease, enabling the identification of disease‐associated protein alterations and candidate biomarkers for diagnosis, progression, and therapeutic response.
Victoria J. Dardov, Aparna Vasanthakumar, Ameya Kulkarni, Niveda Sundararaman, Rakhi Pandey, Preeti Bais, Jennifer E. Van, Maria Quinton, Barry Landin, David Vismer, Bradford Casey, Matt Bookman, Willy Nojopranoto, Erin Teeple, Can Kayatekin, Rajaraman Krishnan, Richard Hargreaves, Guhan Nagappan, S. Pablo Sardi, Sri Ramulu Pullagura, Christine Swanson‐Fischer, Accelerating Medicines Partnership Parkinson's Disease (AMP PD) Proteomics Working Group   +21 more
wiley   +1 more source

Structural Change of ApoE-Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption. [PDF]

J Am Chem Soc
Mo Y, Liu H, Keszei AFA, Dai DL, Makky A, Ding L, Pan A, Bu J, Mazhab-Jafari MT, Chen J, Zheng G.   +10 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Insulin resistance (TyG index) and body mass index as metabolic biomarker combined with ApoE genotype to diagnose Alzheimer's disease. [PDF]

Front Aging Neurosci
Chen R, Fan S, Di C, Wu H, Shi Z, Liu F, Lv Z, Liu S, Ji Y.   +8 more
europepmc   +1 more source

Image Analysis Platform for Comprehensive Quantification of Extracellular Vesicle Morphology

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐encapsulated nanoparticles with key roles in cell biology and growing importance in biomedicine. However, EVs are challenging to characterize because they are highly heterogeneous. Single EV analysis methods are valuable tools for addressing this challenge.
Alexander Spark, Nan Jiang, Benjamin Purnell, Mihajlo Radmilovic, Andras Saftics, Eugenia Romano, Tijana Jovanovic‐Talisman, Alexandre Kitching   +7 more
wiley   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Liver-metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the dementia platform Korea trial-ready registry. [PDF]

Front Aging Neurosci
Ahn YH, Kang JG, Choi D, Kim DJ, Yang CM, Lee SY, Lee SH, Jung YH, Yoon SH.   +8 more
europepmc   +1 more source

Een 'nieuwe' bestuurskunde vraagt eerst om een 'nieuwe' overheid

, 2008
Onlangs riep Koos van der Steenhoven, Secretaris-generaal van het Ministerie van OCW, op om met hem mee te denken over de invulling van de 'nieuwe bestuurskunde', die meer praktisch van aard zou moeten zijn. Graag denk ik met hem mee over de invulling van het bestuurskundig curriculum, maar ik wil toch vooral enkele kanttekeningen plaatsen ...
openaire   +1 more source

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Small, EarlyView.
This article highlights a novel, organic solvent‐free lipid nanoparticle (LNP) formulation that avoids cholesterol, thereby reducing hepatic accumulation and immune activation. These BLNPs enable potent, flexible, and scalable gene delivery, supporting personalized medicine and diverse nucleic acid applications.
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +14 more
wiley   +1 more source