Results 191 to 200 of about 176,190 (308)

Targeting Apolipoprotein E4 rescues photoreceptor degeneration by inhibiting the disease-associated microglia activation in experimental retinal detachment. [PDF]

J Neuroinflammation
Li X, Fan N, Yan Y, Ren M, Wu H, Dong K.
europepmc   +1 more source

Een 'nieuwe' bestuurskunde vraagt eerst om een 'nieuwe' overheid

, 2008
Onlangs riep Koos van der Steenhoven, Secretaris-generaal van het Ministerie van OCW, op om met hem mee te denken over de invulling van de 'nieuwe bestuurskunde', die meer praktisch van aard zou moeten zijn. Graag denk ik met hem mee over de invulling van het bestuurskundig curriculum, maar ik wil toch vooral enkele kanttekeningen plaatsen ...
openaire   +1 more source

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, EarlyView.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source

Health system patterns of imaging and fluid biomarker testing in the era of anti-amyloid therapies. [PDF]

Alzheimers Dement
Robb WH, Kaur G, Huang S, Martinez F, Nguyen B, Shin CH, Yang M, Conyers CT, Grilli CB, Upjohn DP, Ortega VE, Hohman TJ, Keegan RM, Parent EE, Cogswell PM, Graff-Radford J, Johnson DR, Ramanan VK, Koran ME.   +18 more
europepmc   +1 more source

''Ποιότητα ισχύος σε μικροδίκτυα : προβλήματα και μέθοδοι αντιμετώπισης''

Power quality is critical for the efficient operation of power grids and directly affects the reliability and efficiency of systems. The main problems include phase imbalance, voltage drops, voltage fluctuations (flickers), transients, harmonics and interharmonics, frequency fluctuations and low power factor.
openaire   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, EarlyView.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Age at natural menopause, reproductive lifespan and Alzheimer's disease in females: is APOE ε4 the missing link? [PDF]

Front Genet
Bruno F, Spadafora P, Abondio P, Qualtieri A, Paparazzo E, Aceto MA, Veltri I, De Benedittis S, Greco BM, Cerantonio A, Citrigno L, Di Palma G, Gallo O, Passarino G, Montesanto A, Cavalcanti F.   +15 more
europepmc   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

<i>APOE</i> and <i>CCR2</i>: Potential Macrophage-Specific Biomarkers in the Rheumatoid Arthritis Synovial Microenvironment Identified by Bioinformatics and Experimental Verification in Murine Models. [PDF]

J Inflamm Res
Wang D, Lu L, Zhang Y, Shang W.
europepmc   +1 more source

Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis [PDF]

, 2019
Achilefu, Samuel, Guo, Junli, Libby, Peter, Liu, Cong-Lin, Liu, Jing, Liu, Tianxiao, Nahrendorf, Matthias, Shi, Guo-Ping, Sukhova, Galina K., Tang, Rui, Wang, Yunzhe, Wojtkiewicz, Gregory R., Zhang, Jin-Ying, Zhang, Xian   +13 more
core   +1 more source