Results 191 to 200 of about 174,900 (290)

Meta-analysis reveals apolipoprotein ε4 confers higher susceptibility to Parkinson's disease dementia in Asian populations. [PDF]

Front Aging Neurosci
Akhter N, Ho NBP, Nangreave R, Ahmad S, Ducruet AF, Bhatia K.   +5 more
europepmc   +1 more source

''Ποιότητα ισχύος σε μικροδίκτυα : προβλήματα και μέθοδοι αντιμετώπισης''

Power quality is critical for the efficient operation of power grids and directly affects the reliability and efficiency of systems. The main problems include phase imbalance, voltage drops, voltage fluctuations (flickers), transients, harmonics and interharmonics, frequency fluctuations and low power factor.
openaire   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, EarlyView.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

Selective Lipoprotein Removal Enables High‐Purity EV Isolation from Plasma via Aptamer‐Based Mesh Filtration

Small, EarlyView.
A novel affinity‐based mesh filtration system, ApoFilter, enables selective removal of plasma lipoproteins via sequential aptamer‐functionalized layers targeting ApoA1 and ApoB100. While EVs pass through unimpeded, (V)LDL and HDL are rapidly depleted.
SoYoung Jeon, YongWoo Kim, Sehyun Shin
wiley   +1 more source

Slc7a11-Mediated Cystine/Glutamate Antiport Reprograms Macrophage Polarization and Ameliorates Atherosclerosis. [PDF]

MedComm (2020)
Zhou S, Luo Y, Luo J, Li S, Liu B, Shao W, Tao J, Qi J, Fan C, Shi J, An P, Wang H, Wang F.   +12 more
europepmc   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

The APOE paradox: divergent genetic influences on hemorrhagic stroke risk-A meta-analysis. [PDF]

Front Stroke
Nath M, Rai A, Misra S, Kumar P.
europepmc   +1 more source

Critical care delirium: prevention, identification and management: a narrative review

Anaesthesia, EarlyView.
Summary Introduction Delirium is a frequent complication of critical illness and remains an important cause of short‐ and long‐term morbidity for patients admitted to ICUs. Delirium is associated with prolonged mechanical ventilation; extended ICU and hospital stay; and longer‐term health issues. Development is associated with patient (e.g.
Stephanie Kieswick, Ben Gibbison
wiley   +1 more source

Modeling <i>APOE</i>, morbidity, and mortality: a reproducibility challenge for genetic epidemiology. [PDF]

Front Genet
Häggström Gunfridsson E.
europepmc   +1 more source

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, EarlyView.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source