Results 201 to 210 of about 95,989 (269)

Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis

Journal of Diabetes Investigation, EarlyView.
Liraglutide reverses hyperglycemia‐induced metabolic reprogramming in vascular smooth muscle cells, restoring mitochondrial function and AMPK/PGC‐1α signaling while suppressing mTOR activation and HIF‐1α accumulation. These changes attenuate extracellular matrix remodeling, reduce atherosclerotic plaque burden, and improve plaque stability in diabetic ...
Kun Zhu, Hanxiu Liu, Ni He, Haoyang Wang, Jing Liu, Qinhu Zhang, Zhongwei Liu   +6 more
wiley   +1 more source

Longevity and cognitive resilience in a Colombian family carrying the <i>APOE</i> ε2 variant. [PDF]

J Alzheimers Dis
Guerrero A, Galvis-Garrido ND, Bocanegra Y, Vásquez D, Becerra JC, Zuluaga Y, Baena A, Zubiri V, Alzate D, Osorio L, Hincapié L, Madrigal L, García G, Guzmán C, Restrepo F, Vidal M, Martínez L, Martínez JE, Malotaux V, Tristão-Pereira C, Perez-Corredor P, Vacano GN, Lopera F, Arboleda-Velasquez JF, Quiroz YT, Aguillon D.   +25 more
europepmc   +1 more source

The 'State' of 'public' broadcasting in Greece

, 2010
openaire   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population. [PDF]

Neurology
Kim D, McInerney K, Dagli C, Armstrong ND, Cushman M, Bennett A, Blue EE, Sofer T, Sawyer RP, Yuan Y, Crowe M, Judd SE, Olson NC, Irvin MR, Raffield LM.   +14 more
europepmc   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Age-related increase in plasma p-tau217 in amyloid-beta-negative cognitively unimpaired individuals affects diagnostic interpretation. [PDF]

Alzheimers Dement
Mammel AE, Gonzalez-Ortiz F, Mousavi A, Hallett K, Encarnacion M, Biehl D, Gill P, Ismael S, Fowler C, Doecke JD, Ward L, Frykman H.   +11 more
europepmc   +1 more source

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

Clinical and tissue evidence of immune dysregulation in osteosarcoma: altered peripheral neutrophil-related indices and reduced APOE expression. [PDF]

Front Immunol
Zhu J, Huang C, Tan W.
europepmc   +1 more source

The second `'sacred disease'': Earlier euphemistic equivalent of `'Hansen's disease''

, 1996
openaire   +1 more source