Results 221 to 230 of about 277,563 (295)

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Precision medicine requires precision proteomics: discordance between proteomic and clinical assays in UK Biobank. [PDF]

Cardiovasc Res
Singh B, Tzoulaki I, Mayr M.
europepmc   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, EarlyView.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Hypertension Does Not Account for the Accelerated Atherosclerosis and Development of Aneurysms in Male Apolipoprotein E/Endothelial Nitric Oxide Synthase Double Knockout Mice [PDF]

, 2001
Jiqiu Chen, Peter Kuhlencordt, Joshua Astern, Robert Gyurko, Paul L. Huang   +4 more
openalex   +1 more source

Advances in cholesterol and lipoproteins detection for healthcare: A review

VIEW, EarlyView.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta, Somayeh Fardindoost, Azadeh Abdi, Kaveh Yazdani, Longfei Yin, Syamak Farajikhah, Mina Hoorfar, Fariba Dehghani   +7 more
wiley   +1 more source

The Impact of Metabolic Complications in Pregnancy on Later Life Maternal Cardiometabolic Health: Findings From the ROLO Longitudinal Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To explore associations between pregnancy metabolic complications and maternal cardiometabolic health 10 years postpartum. Design Prospective Longitudinal Cohort Study following a randomised controlled trial. Setting Single‐centre. Population Pregnancy metabolic complication (pregnancy‐induced hypertension, impaired glucose tolerance,
Kristyn Dunlop, Sophie Callanan, Kaat Philippe, Catherine McNestry, Alexander Douglass, Ricardo Segurado, Rachel K. Crowley, Patrick J. Twomey, Catherine M. Phillips, Fionnuala M. McAuliffe   +9 more
wiley   +1 more source

Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro‐cognitive interventions show promise, trial findings are inconsistent, potentially due to baseline factors influencing treatment response.
Dimosthenis Tsapekos, Michail Kalfas, Johanna M. Schandorff, Caterina del Mar Bonnin, Christopher R. Bowie, Vicent Balanzá‐Martínez, Katherine E. Burdick, Andre F. Carvalho, Annemieke Dols, Katie Douglas, Peter Gallagher, Gregor Hasler, Lars V. Kessing, Hanne L. Kjærstad, Beny Lafer, Kathryn E. Lewandowski, Carlos López‐Jaramillo, Anabel Martinez‐Aran, Roger S. McIntyre, Richard J. Porter, Scot E. Purdon, Ayal Schaffer, Paul R. A. Stokes, Tomiki Sumiyoshi, Ivan J. Torres, Tamsyn E. Van Rheenen, Lakshmi N. Yatham, Jeff Zarp, Allan H. Young, Eduard Vieta, Kamilla W. Miskowiak   +30 more
wiley   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Neovascular age‐related macular degeneration without drusen

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical characteristics and 1‐year follow‐up of patients with neovascular AMD (nAMD) without drusen in either eye. Methods This is a multicentre retrospective cohort study in three tertiary referral centres in The Netherlands. We included patients of 55 years or older with nAMD in one or both eyes, without the presence
Marc J. Sirks, Elon H. C. van Dijk, Husein Ghalayini, Somayeh Bazdar, WeiFeng Yu, Suzanne Yzer, José P. Martinez Ciriano, Reinier O. Schlingemann, Roselie M. H. Diederen, Camiel J. F. Boon   +9 more
wiley   +1 more source