Results 91 to 100 of about 92,484 (303)

Arginine-directed glycation and decreased HDL plasma concentration and functionality [PDF]

, 2014
Background/Objectives: Decreased plasma concentration of high-density lipoprotein cholesterol (HDL-C) is a risk factor linked to increased risk of cardiovascular disease (CVD). Decreased anti-atherogenic properties of HDL are also implicated in increased
Rabbani, Naila, Smith, L., Godfrey, L. (Lisa), Thornalley, Paul J., Yamada-Fowler, N. (Naomi)   +4 more
core   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Isoproteins of human apolipoprotein A-II: isolation and characterization.

Journal of Lipid Research, 1983
In human serum, polymorphism of apoA-II predominantly in HDL3 could be demonstrated. HDL3-apoA-II was composed of four isoproteins, each with a molecular weight of 8600 (reduced form) and identical immunological properties. The isoproteins are designated
G Schmitz, K Ilsemann, B Melnik, G Assmann   +3 more
doaj   +1 more source

APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample

, 2010
The literature on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP) remains inconsistent, mainly due to low statistical power of previous studies.
Pikhart, H., Peasey, Anne, Pikhart, Hynek, Stavek, Petr, Hubacek, J.A., Kubinova, R., Marmot, Michael, Kubinova, Ruzena, Peasey, A., Hubacek, Jaroslav A., Marmot, M., Stavek, P., Bobak, Martin, Bobak, M.   +13 more
core   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

One-step screening method for the polymorphism of apolipoproteins A-I, A-II, and A-IV

Journal of Lipid Research, 1982
Apolipoprotein A-I exhibits a polymorphism that can be easily investigated in native serum by a simple method involving incubation of serum in the presence of decylsulfate and beta-mercaptoethanol and subsequent isoelectric focusing.
H J Menzel, R G Kladetzky, G Assmann
doaj   +1 more source

Apolipoprotein C-II deficiency: detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients

Journal of Lipid Research, 1988
Recent data suggest that mutant immunoreactive forms of apolipoprotein C-II (apoC-II) can be detected in the plasma of patients with the apoC-II deficiency syndrome. We studied the possible presence of apoC-II mutants in the plasma of two patients with apoC-II deficiency by immunological means.
Francesco Turturro, Francesco Resta, A. M. Mogavero, Alberico L. Catapano, Antonio Capurso, M. Di Tommaso, M. La Rosa, S. Marcovina, P. Taverniti   +8 more
openaire   +4 more sources

Human apolipoprotein A-II inhibits the formation of pre-beta high density lipoproteins

, 1996
The role of human apolipoprotein A-II (apoA-II) in the remodeling of human high density lipoproteins (HDL) was investigated during incubation of native and reduced-carboxamidomethylated (RCM) HDL3 with a lipoprotein-depleted plasma fraction (LPDP) in the
C. Sirtori, G. Vecchio, L. Calabresi, G. Franceschini, A. Lucchini   +4 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Depletion in LpA-I:A-II particles enhances HDL-mediated endothelial protection in familial LCAT deficiency[S]

Journal of Lipid Research, 2017
The aim of this study was to evaluate the vasoprotective effects of HDL isolated from carriers of LCAT deficiency, which are characterized by a selective depletion of LpA-I:A-II particles and predominance of preβ migrating HDL.
Monica Gomaraschi, Alice Ossoli, Samuela Castelnuovo, Sara Simonelli, Chiara Pavanello, Gloria Balzarotti, Marcello Arca, Alessia Di Costanzo, Tiziana Sampietro, Gaetano Vaudo, Damiano Baldassarre, Fabrizio Veglia, Guido Franceschini, Laura Calabresi   +13 more
doaj   +1 more source