Results 41 to 50 of about 92,484 (303)

Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene. [PDF]

, 2006
Apolipoprotein AV (ApoAV) gene variant, -1131T>C, is associated with increased triglyceride concentrations in all ethnic groups studied. An MseI based RFLP analysis is the most commonly used method for genotyping this SNP.
Andrew T Hattersley, Venigalla, Prathyusha NS, Kirsten J Ward, Ward Kirsten J, Hattersley, Andrew T, Ward, Kirsten J, Giriraj R Chandak, Ellard Sian, Timothy M Frayling, Prathyusha NS Venigalla, Frayling, Timothy M, Sian Ellard, Chittaranjan S Yajnik, Hattersley Andrew T, Chandak Giriraj R, Frayling Timothy M, Yajnik Chittaranjan S, Chandak, Giriraj R, Venigalla Prathyusha NS, Ellard, Sian, Yajnik, Chittaranjan S   +20 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Apolipoprotein gene expression in the rabbit: abundance, size, and distribution of apolipoprotein mRNA species in different tissues

Journal of Lipid Research, 1988
We have used human apolipoprotein cDNAs as hybridization probes to study the relative abundance and distribution of apolipoprotein mRNAs in rabbit tissues by RNA blotting analysis.
C Lenich, P Brecher, S Makrides, A Chobanian, V I Zannis   +4 more
doaj   +1 more source

Stimulation of lecithin: cholesterol acyltransferase activity by apolipoprotein A‐II in the presence of apolipoprotein A‐I [PDF]

European Journal of Biochemistry, 1986
Various combinations of incorporation and addition of apolipoprotein A‐I (apo A‐I) and apolipoprotein A‐II (apo A‐II) individually or together to a defined lecithin‐cholesterol (250/12.5 molar ratio) liposome prepared by the cholate dialysis procedure were used to study the effect of apo A‐II on lecithin: cholesterol acyltransferase (LCAT, EC 2.3.1.43)
C H, Chen, J J, Albers
openaire   +2 more sources

Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene. [PDF]

, 2013
: BACKGROUND: Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced.
Srirangalingam, U, Navaratnam, N, Chew, SL, Norman, D, Khoo, B, Akker, SA   +5 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The prognostic significance of HDL-associated apolipoproteins in ascitic fluid from patients with cirrhosis and spontaneous bacterial peritonitis

Scientific Reports
Apolipoproteins (Apo) A-I and A-II are major components of high-density lipoproteins (HDL) with immunomodulatory functions. Low serum apoA-I levels indicate complications of cirrhosis. We hypothesized that HDL-associated apolipoproteins in ascitic fluid (
Mohamad Murad, Philipp A. Reuken, Kristin Schubert, Johanna Reißing, Oluwatomi Ibidapo-Obe, Karsten Große, Mick Frissen, Frederic Haedge, Majda El-Hassani, Martin von Bergen, Tony Bruns   +10 more
doaj   +1 more source

Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism

Journal of Lipid Research, 2009
This study was designed to establish the mechanism responsible for the increased apolipoprotein (apo) A-II levels caused by the cholesteryl ester transfer protein inhibitor torcetrapib. Nineteen subjects with low HDL cholesterol (
Margaret E. Brousseau, John S. Millar, Margaret R. Diffenderfer, Chorthip Nartsupha, Bela F. Asztalos, Megan L. Wolfe, James P. Mancuso, Andres G. Digenio, Daniel J. Rader, Ernst J. Schaefer   +9 more
doaj   +1 more source

Apolipoprotein A-II [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
Apolipoprotein (apo) A-II is the second most abundant protein on high-density lipoprotein (HDL), accounting for ≈20% of total HDL protein.1 Like apo A-I, the most abundant HDL protein, it contains a tandem array of amphipathic helices. It is considered an exchangeable apolipoprotein because it can dissociate from lipoproteins, although it has greater ...
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source