Results 121 to 130 of about 77,676 (146)

Apolipoprotein B-100 Xba I gene polymorphism in gallbladder cancer

Human Genetics, 2004
Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS). Gallstones are among the well-known risk factors for carcinoma of the gallbladder (GBC).
Mahendra Kumar, Singh, Udai Bhan, Pandey, Uday Chand, Ghoshal, Itha, Srivenu, Vinay Kumar, Kapoor, Gourdas, Choudhuri, Balraj, Mittal   +6 more
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Homozygous Familial Defective Apolipoprotein B-100

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Familial defective apolipoprotein B-100 (FDB) is a frequently inherited disorder of lipoprotein metabolism. The glutamine-for-arginine substitution at position 3500 of apolipoprotein (apo) B-100 leads to defective binding of apo B-100 to the low density lipoprotein (LDL) receptor and accumulation of LDL in the plasma.
Schaefer, Juergen R., Scharnagl, Hubert, Baumstark, Manfred, Schweer, Horst, Zech, Loren A., Seyberth, Hansjörg W., Winkler, Karl, Steinmetz, Armin C., März, Winfried   +8 more
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Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100

The Lancet, 1992
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant disorder associated with hypercholesterolaemia in which an aminoacid substitution in apoprotein B-100 leads to low-density lipoprotein (LDL) particles which have defective binding to the LDL receptor.
D R, Illingworth, F, Vakar, R W, Mahley, K H, Weisgraber   +3 more
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Apolipoprotein B-100 Hopkins (Arginine4019 [unk] Tryptophan)

JAMA, 1989
A 43-year-old woman with severe coronary artery disease and hyperapobetalipoproteinemia was heterozygous for an abnormal Msp I apolipoprotein B (APOB) gene fragment because of the absence of the MspI site around codon 4046 in exon 29 of the APOB gene.
openaire   +1 more source

Lipoproteins Containing Apolipoprotein B-100 Are Secreted by the Heart

Trends in Cardiovascular Medicine, 1999
It generally is assumed that lipoproteins containing apolipoprotein B (apo B) are secreted only by the intestine and the liver. However, we recently demonstrated that the human apo-B gene also is expressed in the hearts of human apo-B transgenic mice and in human heart tissue.
M M, Véniant, L B, Nielsen, J, Borén, S G, Young   +3 more
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Apolipoprotein B-100 kinetics in visceral obesity: Associations with plasma apolipoprotein C-III concentration

Metabolism, 2002
Obesity is strongly associated with dyslipidemia, which may account for the associated increased risk of atherosclerosis and coronary disease. We aimed to test the hypothesis that kinetics of hepatic apolipoprotein B-100 (apoB) metabolism are disturbed in men with visceral obesity and to examine whether these kinetic defects are associated with ...
Dick C, Chan, Gerald F, Watts, Trevor G, Redgrave, Trevor A, Mori, P Hugh R, Barrett   +4 more
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Distribution of lipid-binding regions in human apolipoprotein B-100

Biochemistry, 1989
The distribution of lipid-binding regions of human apolipoprotein B-100 has been investigated by recombining proteolytic fragments of B-100 with lipids and characterizing the lipid-bound fragments by peptide mapping, amino acid sequencing, and immunoblotting.
G C, Chen, D A, Hardman, R L, Hamilton, C M, Mendel, J W, Schilling, S, Zhu, K, Lau, J S, Wong, J P, Kane   +8 more
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Structural comparison of human apolipoproteins B-48 and B-100

Biochemistry, 1987
In this study we have investigated the structural relationship between human apolipoproteins B-48 and B-100 by comparing protein structure and by comparing nucleotide sequence from intestinal and hepatic cDNA clones. Sequences from intestinal and hepatic cDNA were identical over the entire distance analyzed (7194 bases), which is more than required to ...
D A, Hardman, A A, Protter, G C, Chen, J W, Schilling, K Y, Sato, K, Lau, M, Yamanaka, T, Mikita, J, Miller, T, Crisp   +9 more
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[11] Isolation and characterization of apolipoprotein B-100

1986
Publisher Summary Two physically separable macromolecules carry the designation apolipoproteinB. The long recognized form of apoB, large apoB or B-100, is the predominant protein in LDL and the major apoB protein found in human VLDL. This chapter describes the isolation and characterization of apolipoprotein B-100.
Waldo R. Fisher, Verne N. Schumaker
openaire   +1 more source

Normotriglyceridemic Abetalipoproteinemia in Infancy: An Isolated Apolipoprotein B-100 Deficiency

Pediatrics, 1985
The plasma lipoproteins of a 1-year-old Japanese infant were studied because of malnutrition, severe decrease in plasma lipid level, and acanthocytosis. Plasma lipoprotein analysis revealed that low-density lipoproteins were deficient; however, low levels of triglyceride-rich lipoproteins were found in the plasma.
Y, Takashima, T, Kodama, H, Iida, M, Kawamura, H, Aburatani, H, Itakura, Y, Akanuma, F, Takaku, M, Kawade   +8 more
openaire   +2 more sources