Results 21 to 30 of about 380,069 (304)
An Investigation of Hepatitis B Virus Genome using Markov Models [PDF]
arXiv, 2023 The human genome encodes a family of editing enzymes known as APOBEC3 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3). Several family members, such as APO-BEC3G, APOBEC3F, and APOBEC3H haplotype II, exhibit activity against viruses such as HIV. These enzymes induce C-to-U mutations in the negative strand of viral genomes, resulting
arxiv
Molecular Dynamics Simulation of Apolipoprotein E3 Lipid Nanodiscs [PDF]
arXiv, 2023 Nanodiscs are binary discoidal complexes of a phospholipid bilayer circumscribed by belt-like helical scaffold proteins. Using coarse-grained and all-atom molecular dynamics simulations, we explore the stability, size, and structure of nanodiscs formed between the N-terminal domain of apolipoprotein E3 (apoE3-NT) and variable number of 1,2-dimyristoyl ...
arxiv
BMC Endocrine Disorders, 2021 Background Apolipoprotein (Apo) may be associated with type 2 diabetes (T2D), however, little is known whether or not serum apolipoproteins are correlated with fasting blood glucose (FBG) and the prevalence of T2D in Chinese populations.
Liang Gao +3 more
doaj +1 more source
Interaction of apolipoprotein(a) with apolipoprotein B-containing lipoproteins.
Journal of Biological Chemistry, 1991 Recombinant DNA-derived apolipoprotein(a) was used to demonstrate that the apo(a) moiety of lipoprotein(a) (Lp(a)) is responsible for the binding of Lp(a) to other apolipoprotein B-containing lipoproteins (apoB-Lp) including LDL2, a subclass of low density lipoproteins (d = 1.030-1.063 g/ml).
Walter J. McConathy +3 more
openaire +3 more sources
A Study of Serum Apolipoprotein A1, Apolipoprotein B and Lipid Profile in Stroke [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background: Role of Serum Lipids, Lipoproteins and Lipoprotein related variables in the prediction of Stroke is less clear. Abnormalities in plasma Lipoproteins are the most firmly established and best understood risk factors for Atherosclerosis and ...
Shilpasree AS +3 more
doaj +1 more source
Clinical significance of leptin in systemic lupus erythematosus
Современная ревматология, 2021 Objective: to study the frequency of hyperleptinemia in patients with systemic lupus erythematosus (SLE), its relationship with clinical and laboratory manifestations of the disease, drug therapy, and other metabolic disorders.Patients and methods.
L. V. Kondratyeva +4 more
doaj +1 more source
Endothelial Cell-specific Loss of Breast Cancer Susceptibility Gene 2 Exacerbates Atherosclerosis [PDF]
arXiv, 2023 The BReast CAncer type 2 susceptibility protein (BRCA2) responds to DNA damage by participating in homology-directed repair. BRCA2 deficiency culminates in defective DNA damage repair (DDR) that when prolonged leads to the accumulation of DNA damage causing cancer or apoptosis.
arxiv
, 1996 Publisher Summary The methods discussed in this chapter provide fairly simple, sensitive, and reliable means of determining the content of apoB-48 and apoB-100 in Sf>12 lipoproteins, by analytical sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), with subsequent conventional protein staining and gel scanning.
Karpe, F +3 more
openaire +4 more sources
Open Medicine, 2023 Adverse cardiovascular events are associated with vascular calcification (VC) process, where vascular smooth muscle cells (VSMCs) differentiate into osteoblastic phenotype and deposit hydroxyapatite crystals. Microtubule-associated protein kinesin family
Li Haibin, Zhang Chunyan, Liu Qiang
doaj +1 more source
Chromosomal breaks at the origin of small tandem DNA duplications
BioEssays, Volume 45, Issue 1, January 2023., 2023 Small tandem DNA duplications form a specific mutational signature frequently found in human disease alleles and cancer genes. Here we hypothesize that these duplications mainly arise at chromosomal DNA breaks that result from two closely located single‐stranded nicks, through error‐prone repair by the non‐homologous end‐joining pathway. Abstract Small
Joost Schimmel +3 more
wiley +1 more source