Results 301 to 310 of about 381,163 (319)

Apolipoprotein B synthesis in humans: Liver synthesizes only apolipoprotein B-100

Metabolism, 1985
Apolipoprotein (apo) B-100 and B-48 are prominent apolipoproteins in VLDL, IDL, and chylomicrons. Organ cultures of normal adult human liver were established to ascertain the form of apo B synthesized by hepatocytes in humans. Human liver was minced and incubated in 15 mL methionine-free RPMI-1640 medium with 10% dialyzed fetal calf serum plus 250 ...
H.B. Brewer, Philip D. Schneider, Jeffrey M. Hoeg, Stephen B. Edge   +3 more
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Apolipoprotein B, the villain in the drama?

European Journal of Pharmacology, 2015
Low-density lipoprotein (LDL) is the major atherogenic lipoprotein and the primary target of lipid-lowering therapy for treating ischemic cardiovascular disease. Apolipoprotein B (apoB), an important structural component of LDL, plays a key role in cholesterol transport and removal in vascular wall.
Cang-Bao Xu, Qi Yu, Yaping Zhang
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Apolipoprotein B intermediates [PDF]

Nature, 1992
Steven L. Chuck, VlSHWANATH R. LlNGAPPA
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Diagnosis and treatment of apolipoprotein B dyslipoproteinemias

Nature Reviews Endocrinology, 2010
Conventionally, atherogenic dyslipidemias have been defined by elevated levels of triglyceride and/or LDL cholesterol. However, cholesterol and triglycerides are not metabolically and physically independent entities. Rather, they are constituents of the atherogenic apolipoprotein B (apoB) particles, which differ in their origin and their metabolic ...
Sniderman, A., Couture, P., Graaf, J. de
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Apolipoproteins A‐I and B in Obese Children

Journal of Pediatric Gastroenterology and Nutrition, 1989
Body mass index (BMI), the distribution of fat, birth weight, physical fitness, apolipoproteins (apo) A‐I and B, total cholesterol (TC), and high‐density lipoprotein cholesterol (HDLC) were studied in 38 obese 10− to 11‐year‐olds in comparison to 52 age‐matched controls.
Göran Fex, Nels Christian Henningsen, Carl-Erik Flodmark, Tomas Sveger   +3 more
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Isolation and characterization of human Lp-B lipoprotein containing apolipoprotein B as the sole apolipoprotein

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
A sequential immunoaffinity chromatography procedure was developed to isolate from whole normolipidemic human plasma a subpopulation of apoB containing particles (Lp-B) which is virtually free of non apoB protein. The absence of non apoB protein in Lp-B was assessed by enzyme immunoassay against apolipoproteins A-I, A-II, A-IV, E, C-III and (a ...
Armin Steinmetz, Jean Marie Bard, Véronique Clavey, Laurent Candelier, G. Agnani, Jean Charles Fruchart, Gérard Torpier   +6 more
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The Role of Apolipoprotein E in Modulating the Metabolism of Apolipoprotein B-48 and Apolipoprotein B-100 Containing Lipoproteins in Humans

1986
ApoE* is a glycoprotein of 299 amino acids which is associated primarily with VLDL and HDL in human plasma (1,2). It is a polymorphic protein with three common alleles inherited in a co-dominant fashion (3,4), the most common allele coding for apoE3. Homozygosity for this allele is present in approximately 60% of normal subjects, and this is considered
Richard E. Gregg, H. Bryan Brewer
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Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia

Atherosclerosis, 2002
Both defective LDL receptors (familial hypercholesterolaemia, FH) and mutations in apolipoprotein B (apoB) on LDL (familial defective apoB, FDB) give rise to a phenotype of elevated LDL cholesterol. We sought to compare the metabolic basis of the two conditions by examining apoB turnover in FDB and FH subjects. A group comprising three heterozygous and
Christopher J. Packard, L. Forster, J.Paul Miller, Gilbert E Wieringa, J. Philip Stewart, Grace Stewart, Dorothy Bedford, Dairena Gaffney, Muriel J. Caslake, Marek H. Dominiczak   +9 more
openaire   +3 more sources

Postprandial changes in the distribution of apolipoprotein AIV between apolipoprotein b- and non apolipoprotein b-containing lipoproteins in obese women

Metabolism, 2003
Plasma apolipoprotein AIV (apo AIV) level has been shown to be a good marker of triglyceride changes after a high-fat diet. However, the distribution of apo AIV between apo B- and non-apo B-containing lipoproteins (Lp) during the postprandial state has not been described as well as the influence of obesity on this distribution. Our aim was to study the
Jean-Marie Bard, Michel Krempf, Yassine Zair, F Ferrer, Hassan Nazih   +4 more
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Risk Stratification of Apolipoprotein B, Apolipoprotein A1, and Apolipoprotein B/AI Ratio on the Prevalence of the Metabolic Syndrome: the ATTICA Study

Angiology, 2008
We investigated the association of apolipoproteins AI and B in relation to the prevalence of metabolic syndrome in a random sample of cardiovascular disease— free adults from the ATTICA study (1,514 men, aged 18-87 y; 1,528 women, aged 18-89 y). Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment ...
Pitsavos, C., Panagiotakos, D.B., Skoumas, J., Papadimitriou, L., Stefanadis, C.   +4 more
openaire   +3 more sources