Results 301 to 310 of about 13,195,946 (379)

Gut Microbiota Regulate Lipid Metabolism via the Bile Acid Pathway: Resistance to Hypoxia in Gansu Zokor (Eospalax cansus)

Integrative Zoology, EarlyView.
The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang, Yingying Zhang, Zhuohang Li, Tianyi Liu, Jianping He, Jingang Li   +5 more
wiley   +1 more source

Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study.

, 1994
Ernst J. Schaefer, Stefania Lamon‐Fava, S D Cohn, M M Schaefer, José M. Ordovás, William P. Castelli, Peter W.F. Wilson   +6 more
openalex   +1 more source

Multi‐Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences

Aging Cell, EarlyView.
The connections between epigenetic age acceleration (EAA) and the multi‐ome, as well as the extent to which these connections are driven by genetic and environmental factors, remain underexplored. We identified blood proteins, metabolites, and exposures associated with EAA in young adults and, using twin study designs, show that these associations are ...
Gabin Drouard, Sannimari Suhonen, Aino Heikkinen, Zhiyang Wang, Jaakko Kaprio, Miina Ollikainen   +5 more
wiley   +1 more source

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

Aging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez, Cristina Nuñez‐Diaz, Kelly Do Huynh, Marie Minh Thu Nguyen, Celia Da Cunha, Francisco J. Cantero‐Molina, Cynthia Campos‐Moreno, Stefania Zimbone, Francesco Bellia, Maria Laura Giuffrida, Laura Trujillo‐Estrada, Juan Antonio Garcia‐Leon, Miriam Bettinetti‐Luque, Nazaret Gamez, Catalina Valdes, Rodrigo Morales, Stefania Forner, Alessandra C. Martini, Antonia Gutierrez, Frank M. LaFerla, David Baglietto‐Vargas   +20 more
wiley   +1 more source

Serum apolipoprotein B to apolipoprotein A-I ratio predicts mortality in patients with heart failure. [PDF]

ESC Heart Fail
Li S, Xie X, Zeng X, Wang S, Lan J.
europepmc   +1 more source

Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and -independent pathways in rabbits.

, 1990
Hitoshi Shimano, N Yamada, Shun Ishibashi, Kenji Harada, Akiyo Matsumoto, Natsuko Mori, Tomohiro Inaba, K Motoyoshi, Hiroshige Itakura, Fumimaro Takaku   +9 more
openalex   +1 more source

Microglia Single‐Cell RNA‐Seq Enables Robust and Applicable Markers of Biological Aging

Aging Cell, EarlyView.
This study develops computational approaches to translate single‐cell based transcriptomic signatures of microglia into aging clocks, or machine learning models of age. These models can be broadly applied to new single‐cell or bulk RNA‐sequencing datasets to gain novel biological insights and evaluate how environmental inputs (such as stress) affect ...
Natalie Stanley, Luvna Dhawka, Sneha Jaikumar, Yu‐Chen Huang, Anthony S. Zannas   +4 more
wiley   +1 more source

Effect of Adding Apolipoprotein B Testing on the Prevalence of Dyslipidemia and Risk of Cardiovascular Disease in the Korean Adult Population. [PDF]

Metabolites
Choi R, Lee SG, Lee EH.
europepmc   +1 more source

Human apolipoprotein B signal sequence variants confer a secretion-defective phenotype when expressed in yeast.

, 1994
Stephen L. Sturley, Philippa J. Talmud, Robert Brasseur, Michael R. Culbertson, Steve E. Humphries, Alan Attie   +5 more
openalex   +1 more source

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Aging Cell, EarlyView.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu, Joanna Bons, Hannah Anvari, Tomiris Atazhanova, Nicolas Martin, Tommy Tran, Kevin Schneider, Jacob P. Rose, Daniel Winer, Elisheva Shanes, Mary Ellen G. Pavone, Judith Campisi, David Furman, Simon Melov, Birgit Schilling, Francesca E. Duncan   +18 more
wiley   +1 more source