Results 181 to 190 of about 196,159 (307)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study. [PDF]

Alzheimers Dement
Suemoto CK, Paradela R, Leite REP, Paes VR, Pasqualucci CA, Ferriolli E, Zatz M, do Nascimento Santos G, de Alexandria MALS, Pereira AC, Fortea J, Naslavsky M, Grinberg LT.   +12 more
europepmc   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Apolipoprotein E (APOE) Promotes Cell Proliferation and Invasion in Glioma via the PI3K/AKT Signaling Pathway. [PDF]

Cancer Manag Res
Xia M, Chen K, Chen W, Ren Z, Li X.
europepmc   +1 more source

Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease

Neuroprotection, EarlyView.
In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong, Andrew Octavian Sasmita, Rhun Yian Koh, Anna Pick Kiong Ling   +3 more
wiley   +1 more source

Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1). [PDF]

J Biol Chem
Zhang DY, Wang J, Huang G, Dokholyan M, Willcox S, Griffith J, Ding F, Dokholyan NV.   +7 more
europepmc   +1 more source

Weight Change Between Pregnancies and Mortality Over 50 Years of Follow‐Up

Obesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate the link between postpartum weight retention (PPWR) and long‐term mortality. Methods In this secondary analysis of 8165 women with ≥ 2 pregnancies in the Collaborative Perinatal Project (CPP), U.S., 1959–1966, with vital status follow‐up through 2016, we used interconception weight change (ICWC) and ...
Yajnaseni Chakraborti, Sunni L. Mumford, Edwina H. Yeung, Katherine L. Grantz, Pauline Mendola, James L. Mills, Ellen C. Caniglia, Colleen M. Brensinger, Cuilin Zhang, Enrique F. Schisterman, Stefanie N. Hinkle   +10 more
wiley   +1 more source

Editorial: Alzheimer’s disease [PDF]

Exploration of Neuroscience
Ryszard Pluta
doaj   +1 more source

Conformational features of guinea pig apolipoprotein E offer insights into functioning of human apolipoprotein E. [PDF]

Arch Biochem Biophys
Reddick I, Celis G, Pal S, Nguyen JT, Saraswathi D, Garai K, Narayanaswami V.   +6 more
europepmc   +1 more source

The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet‐Induced and Genetically Obese Mice

Obesity, EarlyView.
ABSTRACT Objective We aimed to examine the effect of obesity on the plasma free fatty acid (FFA) carrier proteome in mice. Methods From 6 to 20 weeks of age, male and female C57BL/6J wild‐type mice were fed either a low‐fat diet (10% of kilocalories from fat) or a high‐fat diet (60% of kilocalories from fat), and leptin‐deficient ob/ob mice were fed a ...
Keigo Tomoo, Yi Zhang, Ariana Zoe Diaz Portalatin, Gregory C. Henderson   +3 more
wiley   +1 more source