Results 301 to 310 of about 20,685,408 (374)

LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice [PDF]

, 2018
Jeong, Lak Shin, Jeong, Se-Jin, Kim, Gyudong, Oh, Goo Taeg, Park, Jong-Gil, Yu, Jinha   +5 more
core   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Alcohol consumption and risk of dementia: a systematic review and meta‐analysis

Internal Medicine Journal, EarlyView.
Abstract To examine the relationship between alcohol intake and the risk of developing dementia, we conducted a comprehensive search of PubMed, Embase, Cochrane Library and Web of Science databases for relevant studies up to July 22, 2024. The quality of the original studies was appraised utilising the Newcastle‐Ottawa Scale (NOS).
Ren Zhang, Baitao Li, Yue Miao
wiley   +1 more source

Pre-treatment serum apolipoprotein E: a promising prognostic indicator for nasopharyngeal carcinoma. [PDF]

Eur J Med Res
He XM, Jiang SC, Luo QW, Ding JW, Hu RH, Hu JL, Liu MM, Tao L, Zhang JZ, Wu JY, Deng S, Zeng L.   +11 more
europepmc   +1 more source

APOE ε4 and Decline in Health and Financial Literacy in Advanced Age

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Health and financial literacy decline in aging, but it is unclear why. In this study, we hypothesized that older people who are carriers of the APOE ε4 allele exhibit a steeper decline in literacy over time. Methods Participants were 851 community‐dwelling older adults without dementia at analytic baseline (188 ε4 carriers and 663 ...
Christopher C. Stewart, Lei Yu, Alifiya Kapasi, David A. Bennett, Patricia A. Boyle   +4 more
wiley   +1 more source

Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages. [PDF]

J Virol
Schmalzriedt DL, Aurubin CA, Rahlf CR, Brown MA, Bobek JM, Lange PT, Bradeen XG, Sahoo D, Tarakanova VL.   +8 more
europepmc   +1 more source

The Development of a Model to Predict Cognitive Decline Within 12 Months in Home Care Clients

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To develop and validate a model to predict cognitive decline within 12 months for home care clients without a diagnosis of dementia. Design We included all adults aged ≥ 18 years who had at least two interRAI Home Care assessments within 12 months, no diagnosis of dementia and a baseline Cognitive Performance Scale score ≤ 1.
Gary Cheung, Ruth Teh, Eamon Merrick, Nicole Williams, Dawn M. Guthrie   +4 more
wiley   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression. [PDF]

Adv Sci (Weinh)
Shi J, Li Z, Sun X, Yang Y, Luo Y, Song Z, Dong H, Jin L, Xie J, Shan Y, Zhao G.   +10 more
europepmc   +1 more source

Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non‐Diabetic Hyperglycaemia

Journal of Sleep Research, EarlyView.
ABSTRACT Insomnia may play a causal role in type 2 diabetes (T2D). Addressing insomnia through cognitive behavioural therapy (CBTi) in people with non‐diabetic hyperglycaemia could potentially reduce the risk of progression to T2D. To inform a future randomised trial, we performed a feasibility study of digital CBT (dCBTi) in individuals at increased ...
Rachel Sharman, David Ray, Andrew Farmer, Poppy C. E. Green, Victoria Harris, Fredrik Karpe, Colin A. Espie, Diana Mantripp, Thomas Marjot, Niall M. McGowan, Jeremy W. Tomlinson, Simon D. Kyle   +11 more
wiley   +1 more source