Results 301 to 310 of about 19,002,199 (367)

Apolipoprotein E elicits target-directed miRNA degradation to maintain neuronal integrity. [PDF]

Neural Regen Res
Tan J, Ong CT.
europepmc   +1 more source

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

Small Methods, EarlyView.
In vivo, screening of DNA nanostructures yields a cube‐shaped structure (D‐Cb) as a protein corona‐assisted platform for brain delivery of oligonucleotide therapeutics. D‐Cb effectively delivers polo‐like kinase 1 (PLK‐1) antisense oligonucleotides (ASO) to treat glioblastoma in an orthotopic mouse model, demonstrating its potential as a carrier for ...
Kyoung‐Ran Kim, Ji Hee Kang, Hien Bao Dieu Thai, Ji Hyun Back, Chengde Mao, Ji Eun Lee, Young Tag Ko, Dae‐Ro Ahn   +7 more
wiley   +1 more source

[Retracted] Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF‑κB activation in apolipoprotein‑E‑deficient mice. [PDF]

Mol Med Rep
Zhao D, Tong L, Zhang L, Li H, Wan Y, Zhang T.   +5 more
europepmc   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease. [PDF]

Sci Rep
Medegan Fagla B, York J, Christensen A, Dela Rosa C, Balu D, Pike CJ, Tai LM, Buhimschi IA.   +7 more
europepmc   +1 more source

Hyperlipidemia and apolipoprotein E are associated with intraocular pressure of thyroid-associated ophthalmopathy in a Chinese population: a cross-sectional study. [PDF]

Front Endocrinol (Lausanne)
Chen Y, Qi X, Wang J, Xu H, Sun Y, Wang L, Zhou X, He M, Zhao J, Zhang J, He H, Guo H, Shi B, Wang Y, Zhang M.   +14 more
europepmc   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Apolipoprotein E in dense deposits: a parting of the ways in C3 glomerulopathy. [PDF]

Clin Kidney J
Tavares J, Caravaca-Fontán F, Praga M.
europepmc   +1 more source

Human apolipoprotein E glycosylation and sialylation: from structure to function. [PDF]

Front Mol Neurosci
Moon HJ, Luo Y, Chugh D, Zhao L.
europepmc   +1 more source