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Genotyping of Apolipoprotein E
2003Apolipoprotein E (apo E) is a 299-amino acid plasma protein involved in cholesterol transport and is found in chylomicrons, very low density lipopro-tein, intermediate-density lipoprotein, and high-density lipoprotein (1,1).
I. Cetin Ozturk +2 more
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Current Opinion in Neurology, 1996
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
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Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in situ. In the present work, primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro. The astrocytes in culture contained immunoreactive apolipoprotein E in the area of the Golgi apparatus ...
Susan H. Lee +4 more
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[10] Quantitation of apolipoprotein E
1996Quantitation of apoE has proved to be extremely useful in studies of the regulation of apoE synthesis and metabolism. Measurement of serum apoE and/or its distribution among the lipoprotein classes may have clinical utility, although this remains to be established.
Elaine S. Krul, Thomas G. Cole
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Apolipoprotein E phylogeny and evolution
Cell Biochemistry and Function, 2007AbstractAmong apolipoproteins, apolipoprotein E (Apo E) plays a pivotal role in lipid transport and is proposed to be involved in neural repair. Because of a long divergence history of apolipoproteins, it is unclear how Apo E evolved in time. To investigate relationships among Apo E proteins, we used the information from molecular data and analysed the
Ergül, Emel +3 more
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Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease
Ageing Research Reviews, 2009The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area of research,making it one of the most prolifically published areas in medicine and biology. Numerous putative candidate genes have been proposed. However, with the exception of apolipoprotein E (APOE), the only confirmed genetic risk factor for SAD, all the other ...
Grazia D'Onofrio +7 more
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Apolipoprotein E Polymorphism in Sheep
Biochemical Genetics, 1998Using polyacrylamide gel isoelectric focusing followed by immunoblotting with anti-human apolipoprotein E (APO E) antibody, the genetic polymorphism of APO E was determined from desialylated plasma of 554 unrelated adults of four European sheep (Suffolk, Corriedale, Cheviot, and Finnish Landrace) and five Asian local sheep (Bhyanglung, Baruwal, Kagi ...
Ho Van Son +6 more
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ApolipoproteinE and Alzheimer's Disease [PDF]
Biochemical Society Transactions, 1996 Abstract: The specific molecular pathway by which apolipoprotein E modifies the expression of Alzheimer's disease remains elusive. Isoform‐ specific interactions of apolipoprotein E with other molecules determine the outcome from other neurologic disorders and may provide more tractable model systems.
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Apolipoprotein E allele in centenarians [PDF]
Neurology, 1996 Sobel et al., 1 reporting the prevalence of apolipoprotein E (apoE) genotypes among Finnish centenarians, noted that the presence of the e4 allele does not necessarily lead to Alzheimer's disease (AD) in this population and suggested that the relationship between the apoE e4 allele and AD may be age-dependent.
Takashi Asada +4 more
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Apolipoprotein E and amyloidogenesis.
Ciba Foundation symposium, 1996Alzheimer's amyloid beta-protein (A beta) is a modified, pathogenic form of a constitutive host protein, soluble amyloid beta-protein (sA beta). Both are conformational isomers encoded by the gene for the beta-amyloid precursor protein (APP), located on chromosome 21.
Thomas Wisniewski +5 more
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