Results 321 to 330 of about 19,002,199 (367)
Some of the next articles are maybe not open access.
Apolipoprotein E and the Apolipoprotein E-Deficient Mouse
Annual Review of Nutrition, 1995Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate ...
Jan L. Breslow, Andrew S. Plump
openaire +3 more sources
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
Science, 1988Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body.
R. Mahley
semanticscholar +1 more source
Apolipoprotein E and atherosclerosis
Current Opinion in Lipidology, 2000Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants.
Linda K. Curtiss, William A. Boisvert
openaire +2 more sources
Apolipoprotein E in Hyperlipidemia
Annals of Internal Medicine, 1994To review DNA analysis of apolipoprotein E used to assess patients with hyperlipidemia.44 basic science studies of molecular analysis; 42 basic science studies of the biochemical, cellular biological, and molecular biological features of apolipoprotein E; and 29 clinical investigational studies, meta-analyses, and case series of patients with mutations
Robert A. Hegele, Cristina C. Walden
openaire +3 more sources
, 1997
Objective. —To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. Data Sources.
L. Farrer +9 more
semanticscholar +1 more source
Objective. —To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. Data Sources.
L. Farrer +9 more
semanticscholar +1 more source
Apolipoprotein in E in Myasthenia Gravis
Annals of the New York Academy of Sciences, 1998It is believed that apo E may moderate T lymphocytes by activation of mitogens or antigens. In that way, it has an influence on immune processes and it is reasonable to study the relationship between apo E genotypes and myasthenia gravis phenotypes. We tried to find any feature connected to the development of a different intensity of myasthenia gravis.
Marija Šoštarko +5 more
openaire +5 more sources
Current Opinion in Neurology, 1996
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
openaire +3 more sources
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
openaire +3 more sources
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in situ. In the present work, primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro. The astrocytes in culture contained immunoreactive apolipoprotein E in the area of the Golgi apparatus ...
Susan H. Lee +4 more
openaire +3 more sources
Genotyping of Apolipoprotein E
2003Apolipoprotein E (apo E) is a 299-amino acid plasma protein involved in cholesterol transport and is found in chylomicrons, very low density lipopro-tein, intermediate-density lipoprotein, and high-density lipoprotein (1,1).
I. Cetin Ozturk +2 more
openaire +3 more sources
[10] Quantitation of apolipoprotein E
1996Quantitation of apoE has proved to be extremely useful in studies of the regulation of apoE synthesis and metabolism. Measurement of serum apoE and/or its distribution among the lipoprotein classes may have clinical utility, although this remains to be established.
Elaine S. Krul, Thomas G. Cole
openaire +3 more sources