Results 331 to 340 of about 19,002,199 (367)

Apolipoprotein E phylogeny and evolution

Cell Biochemistry and Function, 2007
AbstractAmong apolipoproteins, apolipoprotein E (Apo E) plays a pivotal role in lipid transport and is proposed to be involved in neural repair. Because of a long divergence history of apolipoproteins, it is unclear how Apo E evolved in time. To investigate relationships among Apo E proteins, we used the information from molecular data and analysed the
Ergül, Emel, Akpınar, Gürler, Kasap, Murat, Sazcı, Ali   +3 more
openaire   +3 more sources

Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease

Ageing Research Reviews, 2009
The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area of research,making it one of the most prolifically published areas in medicine and biology. Numerous putative candidate genes have been proposed. However, with the exception of apolipoprotein E (APOE), the only confirmed genetic risk factor for SAD, all the other ...
Grazia D'Onofrio, Alberto Pilotto, Francesco Panza, Bruno Dallapiccola, Bruno Dallapiccola, Davide Seripa, Vincenzo Solfrizzi, Marilisa Franceschi   +7 more
openaire   +2 more sources

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

Journal of the American Medical Association (JAMA), 1997
OBJECTIVE To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations.
L. Farrer, L. Cupples, J. Haines, B. Hyman, W. Kukull, R. Mayeux, R. Myers, M. Pericak-Vance, N. Risch, C. Duijn   +9 more
semanticscholar   +1 more source

ApolipoproteinE and Alzheimer's Disease [PDF]

Biochemical Society Transactions, 1996
Abstract: The specific molecular pathway by which apolipoprotein E modifies the expression of Alzheimer's disease remains elusive. Isoform‐ specific interactions of apolipoprotein E with other molecules determine the outcome from other neurologic disorders and may provide more tractable model systems.
openaire   +4 more sources

Nanobody-Based Apolipoprotein E Immunosensor for Point-of-Care Testing.

ACS Sensors, 2017
Alzheimer's disease (AD) biomarkers can reflect the neurochemical indicators used to estimate the risk in clinical nephrology. Apolipoprotein E (ApoE) is an early biomarker for AD in clinical diagnosis.
Xiang Ren, Junrong Yan, Dan Wu, Q. Wei, Yakun Wan   +4 more
semanticscholar   +1 more source

Apolipoprotein E and amyloidogenesis.

Ciba Foundation symposium, 1996
Alzheimer's amyloid beta-protein (A beta) is a modified, pathogenic form of a constitutive host protein, soluble amyloid beta-protein (sA beta). Both are conformational isomers encoded by the gene for the beta-amyloid precursor protein (APP), located on chromosome 21.
Thomas Wisniewski, Jorge Ghiso, Ruben Vidal, Frances Prelli, Blas Frangione, Eduardo M. Castaño   +5 more
openaire   +3 more sources

Apolipoprotein E allele in centenarians [PDF]

Neurology, 1996
Sobel et al., 1 reporting the prevalence of apolipoprotein E (apoE) genotypes among Finnish centenarians, noted that the presence of the e4 allele does not necessarily lead to Alzheimer's disease (AD) in this population and suggested that the relationship between the apoE e4 allele and AD may be age-dependent.
Takashi Asada, Zentaro Yamagata, Toru Kinoshita, Tetsuhiko Kariya, Akio Asaka   +4 more
openaire   +2 more sources

Molecular biology of apolipoprotein E

Current Opinion in Lipidology, 2002
Apolipoprotein E, first identified 26 years ago as a serum protein that mediates extracellular cholesterol transport, is now known to regulate multiple additional metabolic pathways. Several clinically important disorders of the vasculature and brain are differentially caused, or modified, by the three isoforms of this protein.
Carol Bova Hill, Warren J. Strittmatter
openaire   +3 more sources

Apolipoprotein E polymorphism in Saudis [PDF]

Molecular Biology Reports, 2005
Apolipoprotein E (apoE) genotypes were determined in 165 Saudis. The prevalence of genotype, E3/E3, E3/E4 and E4/E4 was found to be 71, 27 and 2% respectively. The E3/E3 was the most prevalent genotype among the Saudis followed by E3/E4. However, other genotypes E2/E2, E2/E3 and E2/E4 were absent showing the absence of E2 allele in the test population.
openaire   +2 more sources

Apolipoprotein E levels in vegetarians

Metabolism, 1982
Vegetarians are known to have low lipoprotein lipid and apolipoprotein Al and B levels. Since dietary cholesterol has recently been shown to have important effects on apolipoprotein E (apo E) metabolism, we measured plasma apo E levels in three groups of vegetarians. Group I (n = 36) consumed less than 10 mg cholesterol daily and 42% of calories as fat
Anne Varhol, Gustav Schonfeld, Susan Grimes, Dennis R. Lock, Wolfgang Patsch   +4 more
openaire   +3 more sources