Results 331 to 340 of about 195,708 (344)
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Future Lipidology, 2008
Apolipoprotein E4 is a risk factor for developing Alzheimer’s disease (AD) at an earlier age. Anxiety is most common in AD patients with an age-at-onset under 65 years old. We hypothesize that differential effects of human ApoE isoforms on anxiety contribute to this effect.
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Apolipoprotein E4 is a risk factor for developing Alzheimer’s disease (AD) at an earlier age. Anxiety is most common in AD patients with an age-at-onset under 65 years old. We hypothesize that differential effects of human ApoE isoforms on anxiety contribute to this effect.
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Apolipoprotein E and cognitive performance
Nature, 2000Key proteins implicated in the development of Alzheimer's disease are the β-amyloid precursor protein, which gives rise to the β-amyloid peptides that accumulate in the deteriorating brain1,2, and the different isoforms of apolipoprotein E (apoE). The apoE4 variant increases the risk of developing the disease compared with apoE3 (ref. 3).
Jacob Raber +6 more
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Polymorphism of Apolipoprotein E
1980Plasma cholesterol levels are under multifactorial control. Environmental as well as genetic factors contribute to the considerable variance of cholesterol concentrations within and in between populations. Individual genes responsible for the normal variance of cholesterol in plasma have however not yet been identified.
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The Role of Apolipoprotein E and Apolipoprotein B in Atherosclerosis
1991Two apolipoproteins (apo-), apo-B100 and apo-E, are extremely important in lipoprotein metabolism and in the development of accelerated atherosclerosis. Their significance stems from their role in binding to the low density lipoprotein (LDL) receptor and mediating the catabolism of lipoproteins via the LDL receptor pathway.
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Apolipoprotein E and cholesterol metabolism
Klinische Wochenschrift, 1983The role of apo-E in mediating lipoprotein interaction with specific receptors has been established. Through the use of selective chemical modification of specific amino acid residues of certain lipoproteins, we have gained insight into the importance of the lysine and arginine residues in this process. This understanding has been expanded by structure-
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Functional Domains of Apolipoprotein E and Apolipoprotein B
Acta Medica Scandinavica, 1987Thomas L. Innerarity +3 more
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Neurology, 1994 Apolipoprotein B and apolipoprotein E genotypes and sporadic holoprosencephaly
American Journal of Medical Genetics, 2002Robert Clinton Barber +5 more
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