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Apolipoprotein E and Atherosclerosis
Current Atherosclerosis Reports, 2021The functions, genetic variations and impact of apolipoprotein E on lipoprotein metabolism in general are placed in the context of clinical practice dealing with moderate dyslipidaemia as well as dysbetalipoproteinemia, a highly atherogenic disorder and lipoprotein glomerulopathy.Additional variants of apolipoprotein E and participation of ...
A. Marais
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Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms.
Annual Review of Pathology, 2021Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves dysregulation of many cellular and molecular processes. It is notoriously difficult to develop therapeutics for AD due to its complex nature.
Nicole Koutsodendris +3 more
semanticscholar +1 more source
Apolipoprotein E and the Apolipoprotein E-Deficient Mouse
Annual Review of Nutrition, 1995Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate ...
A S, Plump, J L, Breslow
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Neurology, 1995
To the Editor: We made three major points in our paper [1] published in the August 1994 issue of Neurology. First, we found that two of 28 cognitively normal people over the age of 90 had inherited the apolipoprotein E (ApoE) epsilon4 allele (see table 1 in reference 1). This suggests that it is possible to …
G W, Rebeck, B T, Hyman
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To the Editor: We made three major points in our paper [1] published in the August 1994 issue of Neurology. First, we found that two of 28 cognitively normal people over the age of 90 had inherited the apolipoprotein E (ApoE) epsilon4 allele (see table 1 in reference 1). This suggests that it is possible to …
G W, Rebeck, B T, Hyman
openaire +2 more sources
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease.
Pathology (Sydney), 2019Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids, predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to mediate the clearance of their remnants after enzymatic lipolysis in the circulation.
A. Marais
semanticscholar +1 more source
2013
For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
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For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
openaire +2 more sources
Apolipoprotein E Knockout Models
Current Pharmaceutical Design, 2008Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time.
Genovefa, Kolovou +3 more
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