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Apolipoprotein E Polymorphism and Atherosclerosis
Angiology, 2003The relationship between apolipoprotein (apo) E and vascular disease has been the subject of a considerable amount of research. However, this relationship is far from clearly defined. This deficiency appears to be due to a multitude of factors. Among these are differences in ethnicity, age (and possibly gender), diagnostic criteria, and environmental ...
Genovefa Kolovou +2 more
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Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E.
Science, 1992Apolipoprotein E (apoE) is a ligand for receptors that clear remnants of chylomicrons and very low density lipoproteins. Lack of apoE is, therefore, expected to cause accumulation in plasma of cholesterol-rich remnants whose prolonged circulation should ...
Sunny H. Zhang +3 more
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Atherosclerosis, 1998
The current study compared the acute effect of human apolipoprotein (apo) E isoforms on plasma lipids, lipoproteins and apolipoproteins 6 h after a bolus intravenous injection of individual isoforms into apo E-deficient mice.
Jiana Yuan +2 more
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The current study compared the acute effect of human apolipoprotein (apo) E isoforms on plasma lipids, lipoproteins and apolipoproteins 6 h after a bolus intravenous injection of individual isoforms into apo E-deficient mice.
Jiana Yuan +2 more
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Apolipoprotein E phenotypes and hyperlipidemia
Human Genetics, 1984Apolipoprotein E phenotypes were determined in 361 patients with hyperlipidemia and in controls. The E2 isoform was significantly more frequent in the group of hyperlipidemics (P less than 0.0005). This was not due to a higher frequency of E-2/2 homozygotes with type III hyperlipoproteinemia, but rather to a significantly higher frequency of E2 ...
I. Kindermann +3 more
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Apolipoprotein E Knockout Models
Current Pharmaceutical Design, 2008Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time.
Dennis V. Cokkinos +3 more
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Apolipoprotein E and Alzheimer disease
Neurology, 2006Apolipoprotein (apo) E, a multifunctional protein with central roles in lipid metabolism and neurobiology, has three common isoforms (apoE2, apoE3, and apoE4) with different effects on lipid homeostasis and neurobiology. Unlike apoE3, the most common isoform, apoE4, is associated with increased risk of developing Alzheimer disease (AD) and other ...
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Apolipoprotein E polymorphism and gallstones
Gastroenterology, 1996Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by increasing hepatic and biliary cholesterol ...
C Sanllehy +9 more
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Apolipoprotein E genotype and psychosis
Biological Psychiatry, 1997Apolipoprotein E (Apo E) is a protein with 299 amino acids coded by a gene on chromosome 19. The three major isoforms of Apo E (Apo E2, Apo E3, and Apo E4) are products of three alleles (Apo E-e2, Apo E-e3, and Apo E-e4). Inheriting the e4 allele of the Apo E is associated with increased risk of developing Alzheimer's disease (AD).
Shoichi Katsuragi +7 more
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Apolipoprotein E and cognitive performance
Nature, 2000Key proteins implicated in the development of Alzheimer's disease are the β-amyloid precursor protein, which gives rise to the β-amyloid peptides that accumulate in the deteriorating brain1,2, and the different isoforms of apolipoprotein E (apoE). The apoE4 variant increases the risk of developing the disease compared with apoE3 (ref. 3).
Jacob Raber +6 more
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Future Lipidology, 2008
Apolipoprotein E4 is a risk factor for developing Alzheimer’s disease (AD) at an earlier age. Anxiety is most common in AD patients with an age-at-onset under 65 years old. We hypothesize that differential effects of human ApoE isoforms on anxiety contribute to this effect.
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Apolipoprotein E4 is a risk factor for developing Alzheimer’s disease (AD) at an earlier age. Anxiety is most common in AD patients with an age-at-onset under 65 years old. We hypothesize that differential effects of human ApoE isoforms on anxiety contribute to this effect.
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