Results 181 to 190 of about 40,273 (244)

ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition. [PDF]

Sci Rep
Di Biase E, Connolly KJ, Crumpton I, Cooper O, Hallett PJ, Isacson O.   +5 more
europepmc   +1 more source

Temporal Changes in Alzheimer's Disease‐Related Biomarkers in the CSF of Cognitively Normal Subjects at Different Ages: The Chongqing Ageing and Dementia Study

Aging Cell, EarlyView.
The APOE ε4 allele modifies the temporal change in CSF Aβ42 levels among cognitively normal individuals, with the APOE ε4+ group showing an accelerated decline almost 20 years earlier than the APOE ε4− group. ABSTRACT Revealing the temporal evolution of cerebrospinal fluid (CSF) biomarkers during aging is critical to understanding disease pathogenesis ...
Wei‐Wei Li, Dong‐Yu Fan, Qi Sun, Lei‐Kai Wang, Bing‐Qiang Huang, Zhong‐Yuan Yu, Ding‐Yuan Tian, Ying‐Ying Shen, Cheng‐Rong Tan, Gui‐Hua Zeng, Fan Zeng, Jin Fan, Zhen Wang, Yan‐Jiang Wang, Jun Wang   +14 more
wiley   +1 more source

The Potential Causal Association of Apolipoprotein A and B and Age-Related Macular Degeneration: A Mendelian Randomisation Study. [PDF]

Biomedicines
Lee Y, Seo JH.
europepmc   +1 more source

Multi‐Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences

Aging Cell, EarlyView.
The connections between epigenetic age acceleration (EAA) and the multi‐ome, as well as the extent to which these connections are driven by genetic and environmental factors, remain underexplored. We identified blood proteins, metabolites, and exposures associated with EAA in young adults and, using twin study designs, show that these associations are ...
Gabin Drouard, Sannimari Suhonen, Aino Heikkinen, Zhiyang Wang, Jaakko Kaprio, Miina Ollikainen   +5 more
wiley   +1 more source

Endogenous Ketone Bodies Are Associated with Metabolic Vulnerability and Disability in Multiple Sclerosis. [PDF]

Nutrients
Wicks TR, Shalaurova I, Wolska A, Browne RW, Weinstock-Guttman B, Zivadinov R, Remaley AT, Otvos JD, Ramanathan M.   +8 more
europepmc   +1 more source

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

Aging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez, Cristina Nuñez‐Diaz, Kelly Do Huynh, Marie Minh Thu Nguyen, Celia Da Cunha, Francisco J. Cantero‐Molina, Cynthia Campos‐Moreno, Stefania Zimbone, Francesco Bellia, Maria Laura Giuffrida, Laura Trujillo‐Estrada, Juan Antonio Garcia‐Leon, Miriam Bettinetti‐Luque, Nazaret Gamez, Catalina Valdes, Rodrigo Morales, Stefania Forner, Alessandra C. Martini, Antonia Gutierrez, Frank M. LaFerla, David Baglietto‐Vargas   +20 more
wiley   +1 more source

Lipids, apolipoproteins, carbohydrates, and risk of hematological malignancies. [PDF]

Eur J Epidemiol
Liu Q, Wei D, Hammar N, Yang Y, Feychting M, Zhang Z, Walldius G, Smedby KE, Fang F.   +8 more
europepmc   +1 more source

Microglia Single‐Cell RNA‐Seq Enables Robust and Applicable Markers of Biological Aging

Aging Cell, EarlyView.
This study develops computational approaches to translate single‐cell based transcriptomic signatures of microglia into aging clocks, or machine learning models of age. These models can be broadly applied to new single‐cell or bulk RNA‐sequencing datasets to gain novel biological insights and evaluate how environmental inputs (such as stress) affect ...
Natalie Stanley, Luvna Dhawka, Sneha Jaikumar, Yu‐Chen Huang, Anthony S. Zannas   +4 more
wiley   +1 more source

Proteomic and Lipidomic Plasma Evaluations Reveal Biomarkers for Domoic Acid Toxicosis in California Sea Lions. [PDF]

J Proteome Res
Solosky AM, Claudio IM, Chappel JR, Kirkwood-Donelson KI, Janech MG, Bland AM, Gulland FMD, Neely BA, Baker ES.   +8 more
europepmc   +1 more source

Procoagulant activities of plasma factor VIIc and factor Xc are positively and independently associated with concentrations of the high-density lipoprotein apolipoprotein, apoA-II

, 2008
Atta, M, Crook, D, Godsland, IF, Johnston, DG, Shafique, F   +4 more
core   +1 more source