Results 271 to 280 of about 52,991 (293)

Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to identify novel blood‐based biomarkers associated with the early diagnosis of status epilepticus (SE) by exploring proteomic alterations in plasma extracellular vesicles (EVs). Methods We conducted an observational and prospective study in a two‐phase design: a discovery proteomic analysis of plasma EVs ...
Estevo Santamarina, Laura Abraira, Daniel Campos‐Fernández, Manuel Quintana, Elena Fonseca, Samuel López‐Maza, Sofía Lallana, Anna Penalba, Anna Rosell, Júlia Valor‐Blanquer, Clara Sanz, Manuel Toledo   +11 more
wiley   +1 more source

Alcohol consumption and risk of dementia: a systematic review and meta‐analysis

Internal Medicine Journal, EarlyView.
Abstract To examine the relationship between alcohol intake and the risk of developing dementia, we conducted a comprehensive search of PubMed, Embase, Cochrane Library and Web of Science databases for relevant studies up to July 22, 2024. The quality of the original studies was appraised utilising the Newcastle‐Ottawa Scale (NOS).
Ren Zhang, Baitao Li, Yue Miao
wiley   +1 more source

The causal effects of hypothyroidism on cardiovascular disease: Bidirectional and multivariable Mendelian randomization study

Journal of Diabetes Investigation, EarlyView.
Our study suggests bidirectional causal associations between hypothyroidism and both coronary artery disease (CAD) and myocardial infarction (MI). Moreover, hypothyroidism contributes to an increased risk of peripheral atherosclerosis (PAS). ABSTRACT Background Whether hypothyroidism and cardiovascular disease (CVD) are causally related remains ...
Xuan Bai, Mengyi Sun, Xu Han
wiley   +1 more source

Antibodies against oxidized low density lipoproteins (LDL) and apolipoprotein E polymorphism in demented patients

, 2009
Małgorzata Bednarska‐Makaruk, M. Rodo, Ałła Graban, Wanda Łojkowska, Anna Bochyńska, Danuta Ryglewicz, H Wehr   +6 more
openalex   +1 more source

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Associations between maternal mid-pregnancy apolipoprotein A-1, apolipoprotein B, apolipoprotein B/apolipoprotein A-1 ratio and preterm birth

Clinica Chimica Acta, 2022
Elevated lipid levels during pregnancy have been shown to be related to the risk of preterm birth. Despite the importance of apolipoprotein (Apo) in lipid metabolism and transportation, evidence regarding apolipoprotein levels during pregnancy and preterm birth is still limited. Therefore, we aim to investigate the associations between maternal ApoA-1,
Qing, Liu, Li, Wu, Lulin, Wang, Kai, Chen, Yuntao, Wu, Jianhong, Xia, Youjie, Wang   +6 more
openaire   +2 more sources

Apolipoprotein A-I

Journal of Pediatric Gastroenterology and Nutrition, 1990
The apolipoprotein (apo) A‐I:B ratio and the apo B concentration were determined by radial immunodiffusion in dried blood spot samples from 1,767 10‐and 11‐year‐old children. Children with either apo A‐I:B ratios below the first percentile or apo B levels above the 99th were recalled and plasma lipid and apolipoprotein profiles were determined for both
Tomas Sveger, Göran Fex, Carl‐Erik Flodmark, Thomas Kjellström, Nils Borgfors   +4 more
openaire   +1 more source

Apolipoprotein(a): structure and biology

Frontiers in Bioscience, 2001
Apolipoprotein(a), apo(a), the distinctive glycoprotein constituent of lipoprotein(a), Lp(a), is synthesized in the liver, links covalently to apoB100-lipoprotein, and travels so linked in the plasma to tissue sites where removal mechanisms are yet undetermined.
A M, Scanu, K, Nakajima, C, Edelstein
openaire   +2 more sources

Apolipoprotein(a) and atherogenesis

Pathology, 1992
Lipoprotein(a) (Lp(a)) consists of a unique apolipoprotein, apolipoprotein(a), (apo(a)) linked by a disulphide bridge to apolipoprotein B of low density lipoprotein (LDL). Apo(a) is homologous with plasminogen and exhibits genetic polymorphism with the commoner phenotypes due to larger forms being associated with lower plasma levels and the less common
openaire   +2 more sources

Apolipoprotein A-I mimetic peptides

Current Opinion in Lipidology, 2010
To review published data related to the potential applicability of apolipoprotein A-I mimetic peptides.Despite a wealth of information on HDL-C levels and risk for cardiovascular disease (CVD), little evidence is present to suggest that raising HDL-C levels per se will result in CVD risk reduction.
G K, Hovingh, Andrea E, Bochem, John J P, Kastelein   +2 more
openaire   +2 more sources

Free apolipoprotein (a) in abetalipoproteinaemia

Journal of Internal Medicine, 1989
We have estimated the concentrations of free and lipoprotein-bound apo (a) antigen in plasma of a patient with abetalipoproteinaemia. The (a) antigen was quantified by electro-immunoassay using undiluted serum and by a two-site immunoradiometric assay with two different monoclonal antibodies in excess according to the same principles as described for ...
L, Holmquist, A, Hamsten, G H, Dahlén
openaire   +2 more sources