Results 271 to 280 of about 22,660,301 (380)

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

open access: yesSmall Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta   +7 more
wiley   +1 more source

Hyperspectral Raman imaging to understand patterns in dried biofluids in Alzheimer's disease

open access: yesVIEW, EarlyView.
Raman spectroscopy is commonly used to identify biomarkers in biological fluids, often focusing on the outer ring of dried droplets due to molecular accumulation from the coffee ring effect. However, this approach may overlook important spectral information, so hyperspectral Raman mapping is used to analyze the entire droplet and identify optimal ...
Eneko Lopez   +8 more
wiley   +1 more source

Gut Microbiota Regulate Lipid Metabolism via the Bile Acid Pathway: Resistance to Hypoxia in Gansu Zokor (Eospalax cansus)

open access: yesIntegrative Zoology, EarlyView.
The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang   +5 more
wiley   +1 more source

The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.

open access: hybrid, 1983
Karl H. Weisgraber   +6 more
openalex   +1 more source

Multi‐Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences

open access: yesAging Cell, EarlyView.
The connections between epigenetic age acceleration (EAA) and the multi‐ome, as well as the extent to which these connections are driven by genetic and environmental factors, remain underexplored. We identified blood proteins, metabolites, and exposures associated with EAA in young adults and, using twin study designs, show that these associations are ...
Gabin Drouard   +5 more
wiley   +1 more source

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