Results 301 to 310 of about 18,826,161 (368)

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Low apolipoprotein A-II levels causally contribute to increased mortality in septic shock. [PDF]

J Intensive Care
Takahashi N, Campbell KR, Shimada T, Nakada TA, Russell JA, Walley KR.   +5 more
europepmc   +1 more source

Therapeutic Implications of Biomolecular Corona on Lipid Nanoparticle‐Based Gene Delivery Systems

Small Science, EarlyView.
This image illustrates the role of the biomolecular corona in lipid nanoparticles (LNPs), highlighting its impact on the stability, immune response, biodistribution, and targeted delivery. Formed after injection, the corona influences how LNPs circulate, interact with the cells, and modulate the immune response.
Antonietta Greco, Claudia Corbo
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Hyperspectral Raman imaging to understand patterns in dried biofluids in Alzheimer's disease

VIEW, EarlyView.
Raman spectroscopy is commonly used to identify biomarkers in biological fluids, often focusing on the outer ring of dried droplets due to molecular accumulation from the coffee ring effect. However, this approach may overlook important spectral information, so hyperspectral Raman mapping is used to analyze the entire droplet and identify optimal ...
Eneko Lopez, Giulia Gorla, Jaione Etxebarria‐Elezgarai, Julene Aramendia, Kepa Castro, Maite García‐Sebastián, Pablo Martínez‐Lage, Andreas Seifert, Jose Manuel Amigo   +8 more
wiley   +1 more source

Activating transcription factor 3 regulates hepatic apolipoprotein A4 upon metabolic stress. [PDF]

J Biol Chem
Encarnacion J, Smith DM, Choi J, Scafidi J, Wolfgang MJ.   +4 more
europepmc   +1 more source

Gut Microbiota Regulate Lipid Metabolism via the Bile Acid Pathway: Resistance to Hypoxia in Gansu Zokor (Eospalax cansus)

Integrative Zoology, EarlyView.
The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang, Yingying Zhang, Zhuohang Li, Tianyi Liu, Jianping He, Jingang Li   +5 more
wiley   +1 more source

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, EarlyView.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source

Clusterin and pentraxin 3 are markers of severity during febrile neutropenia in adults with haematological malignancies receiving intensive chemotherapy

British Journal of Haematology, EarlyView.
During febrile neutropenia in patients with haematological malignancies, pentraxin 3 (PTX3), a soluble innate immunity receptor, increases with severe sepsis, while clusterin, a chaperon protein involved in extracellular histones clearance, decreases in patients with quick SOFA score (qSOFA) ≥2.
Coralie Mallebranche, Carole Mosnier, Corentin Orvain, Jérémie Riou, Sylvain Thepot, Pascale Pignon, Simon Blanchard, Nathalie Tortevoie, Isabelle Pellier, Mathilde Hunault‐Berger, Pascale Jeannin, Yves Delneste, Aline Schmidt‐Tanguy, Céline Beauvillain   +13 more
wiley   +1 more source