Results 311 to 320 of about 18,538,974 (359)
Some of the next articles are maybe not open access.
Apolipoprotein E and the Apolipoprotein E-Deficient Mouse
Annual Review of Nutrition, 1995Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate ...
A S, Plump, J L, Breslow
openaire +3 more sources
Neurology, 1995
To the Editor: We made three major points in our paper [1] published in the August 1994 issue of Neurology. First, we found that two of 28 cognitively normal people over the age of 90 had inherited the apolipoprotein E (ApoE) epsilon4 allele (see table 1 in reference 1). This suggests that it is possible to …
G W, Rebeck, B T, Hyman
openaire +2 more sources
To the Editor: We made three major points in our paper [1] published in the August 1994 issue of Neurology. First, we found that two of 28 cognitively normal people over the age of 90 had inherited the apolipoprotein E (ApoE) epsilon4 allele (see table 1 in reference 1). This suggests that it is possible to …
G W, Rebeck, B T, Hyman
openaire +2 more sources
Apolipoprotein E and Atherosclerosis
Current Atherosclerosis Reports, 2021The functions, genetic variations and impact of apolipoprotein E on lipoprotein metabolism in general are placed in the context of clinical practice dealing with moderate dyslipidaemia as well as dysbetalipoproteinemia, a highly atherogenic disorder and lipoprotein glomerulopathy.Additional variants of apolipoprotein E and participation of ...
openaire +2 more sources
2013
For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
openaire +2 more sources
For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
openaire +2 more sources
Apolipoprotein E Knockout Models
Current Pharmaceutical Design, 2008Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time.
Genovefa, Kolovou +3 more
openaire +2 more sources
Apolipoprotein E and atherosclerosis
Current Opinion in Lipidology, 2000Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants.
L K, Curtiss, W A, Boisvert
openaire +2 more sources
Apolipoprotein E in Hyperlipidemia
Annals of Internal Medicine, 1994To review DNA analysis of apolipoprotein E used to assess patients with hyperlipidemia.44 basic science studies of molecular analysis; 42 basic science studies of the biochemical, cellular biological, and molecular biological features of apolipoprotein E; and 29 clinical investigational studies, meta-analyses, and case series of patients with mutations
C C, Walden, R A, Hegele
openaire +2 more sources