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Apolipoprotein E--Correction [PDF]
Neurology, 1995 To the Editor: We made three major points in our paper [1] published in the August 1994 issue of Neurology. First, we found that two of 28 cognitively normal people over the age of 90 had inherited the apolipoprotein E (ApoE) epsilon4 allele (see table 1 in reference 1). This suggests that it is possible to …
G. William Rebeck, Bradley T. Hyman
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Apolipoprotein E and Atherosclerosis
Current Atherosclerosis Reports, 2021The functions, genetic variations and impact of apolipoprotein E on lipoprotein metabolism in general are placed in the context of clinical practice dealing with moderate dyslipidaemia as well as dysbetalipoproteinemia, a highly atherogenic disorder and lipoprotein glomerulopathy.Additional variants of apolipoprotein E and participation of ...
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Arteriosclerosis, Thrombosis and Vascular Biology, 1995
We have recently shown that apo B-containing lipoproteins isolated by immunoaffinity chromatography bind to the LDL receptor with an affinity dependent on their apo E or apo CIII content.
V. Clavey +4 more
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We have recently shown that apo B-containing lipoproteins isolated by immunoaffinity chromatography bind to the LDL receptor with an affinity dependent on their apo E or apo CIII content.
V. Clavey +4 more
semanticscholar +1 more source
Apolipoprotein E and the Apolipoprotein E-Deficient Mouse
Annual Review of Nutrition, 1995Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate ...
Jan L. Breslow, Andrew S. Plump
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Biomacromolecules, 2007
Previous in vivo observations in rats have shown that poly(ethylene glycol) polyhexadecylcyanoacrylate (PEG-PHDCA) nanoparticles could translocate into the brain after intravenous injection, which polyhexadecylcyanoacrylate (PHDCA) nanoparticles did not.
H. Kim +8 more
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Previous in vivo observations in rats have shown that poly(ethylene glycol) polyhexadecylcyanoacrylate (PEG-PHDCA) nanoparticles could translocate into the brain after intravenous injection, which polyhexadecylcyanoacrylate (PHDCA) nanoparticles did not.
H. Kim +8 more
semanticscholar +1 more source
Metabolism of high-density lipoprotein apolipoproteins in Tangier disease.
New England Journal of Medicine, 1978To define the metabolic defect in Tangier disease, we studied the kinetics of [125I]-high-density lipoprotein apolipoproteins (apolipoproteins A-I and A-II) in 11 normal subjects, two obligate heterozygotes, and two homozygotes.
E. Schaefer +6 more
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Stable isotope turnover of apolipoproteins of high-density lipoproteins in humans.
Current Opinion in Lipidology, 2000Amino acid precursors labelled with stable isotopes have been successfully used to explore the metabolism of the apolipoproteins of HDL. Some methodological and mathematical modelling problems remain, mainly related to amino acid recycling in a plasma ...
J. Marsh, F. Welty, E. Schaefer
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Apolipoprotein E and atherosclerosis
Current Opinion in Lipidology, 2000Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants.
Linda K. Curtiss, William A. Boisvert
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