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Apolipoprotein E Polymorphism in Sheep
Biochemical Genetics, 1998Using polyacrylamide gel isoelectric focusing followed by immunoblotting with anti-human apolipoprotein E (APO E) antibody, the genetic polymorphism of APO E was determined from desialylated plasma of 554 unrelated adults of four European sheep (Suffolk, Corriedale, Cheviot, and Finnish Landrace) and five Asian local sheep (Bhyanglung, Baruwal, Kagi ...
Ho Van Son +6 more
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ApolipoproteinE and Alzheimer's Disease [PDF]
Biochemical Society Transactions, 1996 Abstract: The specific molecular pathway by which apolipoprotein E modifies the expression of Alzheimer's disease remains elusive. Isoform‐ specific interactions of apolipoprotein E with other molecules determine the outcome from other neurologic disorders and may provide more tractable model systems.
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Apolipoprotein E allele in centenarians [PDF]
Neurology, 1996 Sobel et al., 1 reporting the prevalence of apolipoprotein E (apoE) genotypes among Finnish centenarians, noted that the presence of the e4 allele does not necessarily lead to Alzheimer's disease (AD) in this population and suggested that the relationship between the apoE e4 allele and AD may be age-dependent.
Takashi Asada +4 more
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Apolipoprotein E and amyloidogenesis.
Ciba Foundation symposium, 1996Alzheimer's amyloid beta-protein (A beta) is a modified, pathogenic form of a constitutive host protein, soluble amyloid beta-protein (sA beta). Both are conformational isomers encoded by the gene for the beta-amyloid precursor protein (APP), located on chromosome 21.
Thomas Wisniewski +5 more
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Apolipoprotein E polymorphism in Saudis [PDF]
Molecular Biology Reports, 2005 Apolipoprotein E (apoE) genotypes were determined in 165 Saudis. The prevalence of genotype, E3/E3, E3/E4 and E4/E4 was found to be 71, 27 and 2% respectively. The E3/E3 was the most prevalent genotype among the Saudis followed by E3/E4. However, other genotypes E2/E2, E2/E3 and E2/E4 were absent showing the absence of E2 allele in the test population.
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Molecular biology of apolipoprotein E
Current Opinion in Lipidology, 2002Apolipoprotein E, first identified 26 years ago as a serum protein that mediates extracellular cholesterol transport, is now known to regulate multiple additional metabolic pathways. Several clinically important disorders of the vasculature and brain are differentially caused, or modified, by the three isoforms of this protein.
Carol Bova Hill, Warren J. Strittmatter
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Apolipoprotein E levels in vegetarians
Metabolism, 1982Vegetarians are known to have low lipoprotein lipid and apolipoprotein Al and B levels. Since dietary cholesterol has recently been shown to have important effects on apolipoprotein E (apo E) metabolism, we measured plasma apo E levels in three groups of vegetarians. Group I (n = 36) consumed less than 10 mg cholesterol daily and 42% of calories as fat
Anne Varhol +4 more
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Apolipoprotein E phenotypes and hyperlipidemia
Human Genetics, 1984Apolipoprotein E phenotypes were determined in 361 patients with hyperlipidemia and in controls. The E2 isoform was significantly more frequent in the group of hyperlipidemics (P less than 0.0005). This was not due to a higher frequency of E-2/2 homozygotes with type III hyperlipoproteinemia, but rather to a significantly higher frequency of E2 ...
I. Kindermann +3 more
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Apolipoprotein E Knockout Models
Current Pharmaceutical Design, 2008Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time.
Dennis V. Cokkinos +3 more
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Apolipoprotein E Polymorphism and Atherosclerosis
Angiology, 2003The relationship between apolipoprotein (apo) E and vascular disease has been the subject of a considerable amount of research. However, this relationship is far from clearly defined. This deficiency appears to be due to a multitude of factors. Among these are differences in ethnicity, age (and possibly gender), diagnostic criteria, and environmental ...
Genovefa Kolovou +2 more
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