Results 51 to 60 of about 18,813,566 (369)

Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal. [PDF]

, 2019
Proteins involved in lipoprotein metabolism can modulate cardiovascular health. While often measured to assess adult metabolic diseases, little is known about the proteomes of lipoproteins and their relation to metabolic dysregulation and underlying ...
Christian, Parul, Cole, Robert N, Eroglu, Abdulkerim, Groopman, John, Lee, Sun Eun, Schulze, Kerry, Stewart, Christine P, West, Keith P, Wu, Lee S-F, Yager, James D   +9 more
core  

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Clinical, genotypic and olfactory characteristics of patients with 11C ⁃ PIB ⁃ positive cognitive impairment

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Background To summarize the clinical, genotype and olfactory characteristic in patients with 11 C⁃Pittsburgh compound B (11C⁃PIB)⁃positive cognitive impairment.
Hui⁃hong ZHANG, Pan WAN, Yu⁃chao DOU, Yan WANG, Miao ZHANG, Xiao⁃lin XU, Yu⁃ying ZHOU   +6 more
doaj  

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain*

Journal of Biological Chemistry, 2004
ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein (HDL), where it mediates the efflux of cholesterol and phospholipids ...
Veronica Hirsch-Reinshagen, Steven Zhou, Braydon L. Burgess, L. Bernier, Sean A. McIsaac, Jeniffer Y. Chan, Gavin H Tansley, J. Cohn, M. Hayden, C. Wellington   +9 more
semanticscholar   +1 more source

Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper describes the development of a microscale model that quantifies the breakdown of fibrin by endothelial cells. The small size scale of this engineered system enables fibrin breakdown to be observed without the addition of external activators. This system could help in identifying compounds which both promote and hinder thrombosis.
Jonathan J. Chang, Kelsey Brew, Jamie A.G. Hamilton, Varun Kumar, José A. Diaz, Shuichi Takayama   +5 more
wiley   +1 more source

Plasma Apolipoprotein Levels Are Associated with Cognitive Status and Decline in a Community Cohort of Older Individuals

PLoS ONE, 2012
Objectives Apolipoproteins have recently been implicated in the etiology of Alzheimer’s disease (AD). In particular, Apolipoprotein J (ApoJ or clusterin) has been proposed as a biomarker of the disease at the pre-dementia stage.
Fei Song, A. Poljak, J. Crawford, N. Kochan, W. Wen, B. Cameron, O. Lux, H. Brodaty, K. Mather, G. Smythe, P. Sachdev   +10 more
semanticscholar   +1 more source

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]

, 2018
Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty, Hui, Hussain, Lin, Mahley, Pepe, Roselaar   +6 more
core   +2 more sources

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E

Journal of Lipid Research, 1999
Apolipoprotein (apo) C-I is a constituent of triglyceride-rich lipoproteins (TGRL) that interferes with their hepatic clearance. Functional polymorphism in the apoC-I gene has not been established.
Yan Xu, Lars Berglund, Rajasekhar Ramakrishnan, Richard Mayeux, Colleen Ngai, Steven Holleran, Benjamin Tycko, Todd Leff, Neil S. Shachter   +8 more
doaj  

Rare APOE p.Gly4Glu: A putative disease-causing variant for early-onset Alzheimer’s disease identified by next-generation sequencing

Tzu Chi Medical Journal
Objectives: We aimed to identify the early-onset Alzheimer’s disease (EOAD)-causing variants in the Eastern Taiwanese population. Materials and Methods: Twenty-one patients diagnosed with EOAD in the memory clinic at Hualien Tzu Chi Hospital were ...
Chu-Ting Wu, Liang-Hsuan Hu, Hui-Ying Weng, Yen-Ming Liu, Yung-Feng Lin, Shih-Feng Tsai, Raymond Y. Lo, Yung-Hao Ching   +7 more
doaj   +1 more source