Results 91 to 100 of about 3,080,890 (389)

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Diabetes, 2003
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m2; 41 with type 2 diabetes,
A. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R. Rizza, P. Butler   +5 more
semanticscholar   +1 more source

APOPTOSIS. THE ROLE OF APOPTOSIS IN CANCERS

, 2023
Apoptosis is a complex mechanism that is involved at any stage during organism development or in cellular damage. It is triggered by specific external and internal factors such as ultraviolet radiation, hypoxia, growth factors, viruses, and bacteria, which activate the two main pathways: the extrinsic pathway, also known as the death receptor pathway ...
Orlov Alina, Dumitraș Grigore
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

NK92 cells stably transfected with CD16 are efficient against multiple myeloma cells ex vivo and in vivo, especially if combined with daratumumab

OncoImmunology
Adoptive cell therapy and the use of monoclonal antibodies are two therapeutic modalities implemented in the treatment of multiple myeloma (MM). In this study, we combined the anti-CD38 therapeutic mAb daratumumab with different types of NK cells ...
David Giraldos, Evelyn Galano-Frutos, Laura Cambronero-Arregui, Manuel Beltrán Visiedo, Eduardo Romanos, Chantal Reina-Ortiz, Gemma Azaceta, Beatriz Martínez-Lázaro, Bárbara Menéndez-Jándula, Alejandro García-Romero, Francisco Javier Jiménez-Albericio, Isabel Marzo, Javier Naval, Alberto Anel   +13 more
doaj   +1 more source

Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)

Beilstein Journal of Organic Chemistry, 2013
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with few therapeutic options. While several gene mutations have been implicated in ALS, the exact cause of neuronal dysfunction is unknown and motor neurons of affected individuals
Allison S. Limpert, Margrith E. Mattmann, Nicholas D. P. Cosford   +2 more
doaj   +1 more source

Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening

BMC Infectious Diseases, 2021
Background Macrophages, besides resting latently infected CD4+ T cells, constitute the predominant stable, major non-T cell HIV reservoirs. Therefore, it is essential to eliminate both latently infected CD4+ T cells and tissue macrophages to completely ...
Simon X. M. Dong, Frederick S. Vizeacoumar, Kalpana K. Bhanumathy, Nezeka Alli, Cristina Gonzalez-Lopez, Niranjala Gajanayaka, Ramon Caballero, Hamza Ali, Andrew Freywald, Edana Cassol, Jonathan B. Angel, Franco J. Vizeacoumar, Ashok Kumar   +12 more
doaj   +1 more source

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

Frontiers in Immunology, 2019
Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal environment. Apoptosis is an initiative cell death process that is controlled by genes and is mainly divided into endogenous pathways (mitochondrial pathway ...
Hai Hu, M. Tian, C. Ding, Shengqing Yu
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

eLife, 2017
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g.
Jennifer J Banerjee, Birgit L Aerne, Maxine V Holder, Simon Hauri, Matthias Gstaiger, Nicolas Tapon   +5 more
doaj   +1 more source

Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer

Cell Death and Disease, 2023
Notch signaling is a conserved signaling pathway that participates in many aspects of mammary gland development and homeostasis, and has extensively been associated with breast tumorigenesis.
Sonia Brahim, Ana-Maria Negulescu, Clara Geneste, Thomas Schott, Shuheng Lin, Louis-Oscar Morel, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Patrick Mehlen, Olivier Meurette   +10 more
doaj   +1 more source