Results 151 to 160 of about 3,080,890 (389)

Age-related increase of oxidative stress-induced apoptosis in mice prevention by Ginkgo biloba extract (EGb761) [PDF]

, 2006
Enhanced apoptosis and elevated levels of reactive oxygen species (ROS) play a major role in aging. In addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis in neuronal tissue.
Eckert, Anne, Kreßmann, Sabine, Leutner, Silke, Müller, Walter E., Schindowski, Katharina   +4 more
core  

AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway [PDF]

, 2019
Chia‐Cheng Su, Kun-Lin Hsieh, Po‐Len Liu, Hsin‐Chih Yeh, Shu‐Pin Huang, Shih‐Hua Fang, Wei‐Chung Cheng, Kuan‐Hua Huang, Fang‐Yen Chiu, I‐Ling Lin, Ming‐Yii Huang, Chia‐Yang Li   +11 more
openalex   +1 more source

Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage

, 2022
Miao Wang, Chao Zhou, Lu Yu, Delian Kong, Wei-jing Ma, Bingchen Lv, Yan Wang, Wei-Feng Wu, Mingyue Zhou, Guiyun Cui   +9 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice

Haematologica, 2020
Sarah Ebinger, Christina Zeller, Michela Carlet, Daniela Senft, Johannes W. Bagnoli, Wen-Hsin Liu, Maja Rothenberg-Thurley, Wolfgang Enard, Klaus H. Metzeler, Tobias Herold, Karsten Spiekermann, Binje Vick, Irmela Jeremias   +12 more
doaj   +1 more source

KADAR TNF-aIL-6 DAN APOPTOSIS TROFOBLAST PLASENTA Pada Preeklampsia-Eklampsia dan non Preklampsia-Eklampsia [PDF]

, 2006
Objectives: The aim of this study is to investigate the relation among TNF-a -6 concentration/expression with placental tissue infarction and apoptosis between PE-E and non PE-E.
Susianto, Indra Adi
core  

Targeting apoptosis in cancer therapy

Nature Reviews Clinical Oncology, 2020
B. Carneiro, W. El-Deiry
semanticscholar   +1 more source

Apoptosis [PDF]

Nature, 1989
C A, Smith, G T, Williams, R, Kingston, E J, Jenkinson, J J, Owen   +4 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source