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Homeostatic Apoptosis and Allostatic Apoptosis

International Journal of Science and Healthcare Research, 2022
Genetics and Epigenetics are the integral parts of homeostasis. But it remains unrealistic to assess the health or disease status of the individuals at the genetic or epigenetic level. Fortunately, numerous variables related to homeostasis and allostasis are measurable genetic expressions (phenotypes), thus we are relying primarily on vital signs ...
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Physiology of apoptosis

American Journal of Physiology-Renal Physiology, 2000
Ion fluxes and volume changes of the whole cell as well as of organelles belong to the hallmarks of apoptosis; however, the molecular mechanism regulating these changes is only poorly characterized. Several ion channels in the plasma membrane, in particular the N-type K+channel, the chloride channel cystic fibrosis conductance regulator, and an outward
E, Gulbins   +4 more
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Genetics of Apoptosis

1997
Publisher Summary The genetic analysis of apoptosis, or programmed cell death, provides important information on the biology of naturally occurring cell death. Identification of genes regulating apoptosis has confirmed that this process follows a similar paradigm in all multicellular organisms.
Desnoyers, S, Hengartner, M O
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Apoptosis and ageing

Mechanisms of Ageing and Development, 1998
Stimulation of T cells from aged individuals leads to different kinds and/or size of responses if compared with the responses of T cells obtained from young individuals. In fact elderly is associated with a progressive decline of immune response besides an increasing incidence of autoimmune phenomena.
Potestio M   +8 more
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Liver apoptosis

Journal of Hepatology, 1997
Apoptosis, also called programmed cell death, is a peculiar form of cell death different from cell necrosis in many morphological and biochemical aspects. Like mitosis or differentiation, apoptosis is a normal cell phenomenon which depends on the expression of genes capable of inducing or inhibiting this type of cell destruction. But apoptosis can also
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Apoptosis in leukocytes

Journal of Leukocyte Biology, 1995
Abstract All cells of the hematopoietic system have finite life spans, shorter by far than that of the host. They end their lives by committing a form of cellular suicide or programmed cell death. The morphology of this process is considerably different from that of necrosis and is called apoptosis.
M K, Squier, A J, Sehnert, J J, Cohen
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Viruses and apoptosis

Current Opinion in Genetics & Development, 1995
Apoptosis is an active process of cell death that serves diverse functions in multicellular organisms, and under physiological conditions, it is tightly controlled. Many virus genomes encode gene products that modulate apoptosis, either positively or negatively, and induction of apoptosis often contributes directly to the cytopathogenic effects of the ...
Y, Shen, T E, Shenk
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Apoptosis and autoimmunity

Current Opinion in Immunology, 2005
Autoimmune diseases reflect the confluence of genetic, environmental and stochastic events. Recent studies have implicated apoptotic cell death pathways in initiating and propagating autoimmune diseases, as well as in rendering individuals susceptible to such diseases.
James A, Mahoney, Antony, Rosen
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Mechanisms of apoptosis

Rheumatic Disease Clinics of North America, 2004
The understanding of the apoptotic program has grown exponentially over the past decade. Numerous human diseases have been directly linked to genetic defects in the apoptotic pathways, including cancer, neurodegenerative disorders, and autoimmune diseases.
David A, Martin, Keith B, Elkon
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Apoptosis and osteoporosis

The American Journal of Medicine, 2000
During normal bone remodeling, the rate of supply of new osteoblasts and osteoclasts and the timing of the death of osteoclasts, osteoblasts, and osteocytes by apoptosis are critical determinants of the initiation of new BMUs and the extension or reduction of the lifetime of existing ones.
R S, Weinstein, S C, Manolagas
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