Results 231 to 240 of about 1,251,111 (266)
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Apoptosis, 2001
The TP53 tumour-suppressor gene belongs to a family that includes the two recently identified homologues TP63 and TP73. Overexpression of p73 can activate typical p53-responsive genes and induce apoptosis like p53. In addition, activation of p73 has been implicated in apoptotic cell death induced by aberrant cell proliferation and some forms of DNA ...
T, Stiewe, B M, Pützer
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The TP53 tumour-suppressor gene belongs to a family that includes the two recently identified homologues TP63 and TP73. Overexpression of p73 can activate typical p53-responsive genes and induce apoptosis like p53. In addition, activation of p73 has been implicated in apoptotic cell death induced by aberrant cell proliferation and some forms of DNA ...
T, Stiewe, B M, Pützer
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Apoptosis and apoptosis‐related proteins in thyroid myopathies
Muscle & Nerve, 2002AbstractDNA fragmentation and apoptosis‐related proteins have been investigated in thyroid cells and there is evidence that Fas‐mediated apoptosis is inhibited by thyroid stimulating hormone (TSH). We investigated DNA fragmentation by terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL), and Bcl‐2 and Fas antigen expression by ...
MONICI, M. C. +6 more
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Microbes and Infection, 2018
Apoptosis is one of the principal responses that human cells have at their disposal when faced with changes in their environment. Microbial infection is a massive challenge to a cell, and it is unsurprising that the apoptosis apparatus has been implicated in numerous infections.
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Apoptosis is one of the principal responses that human cells have at their disposal when faced with changes in their environment. Microbial infection is a massive challenge to a cell, and it is unsurprising that the apoptosis apparatus has been implicated in numerous infections.
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Experientia, 1996
The interleukin-1 beta-converting enzyme (ICE)-like family proteases have recently been identified as key enzymes in apoptotic cell death. Among these proteases one can identify specific activities which may be involved in cytokine production or in resident protein cleavage. Several factors influence the constitutive apoptotic mechanism and may provide
B, Zhivotovsky +2 more
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The interleukin-1 beta-converting enzyme (ICE)-like family proteases have recently been identified as key enzymes in apoptotic cell death. Among these proteases one can identify specific activities which may be involved in cytokine production or in resident protein cleavage. Several factors influence the constitutive apoptotic mechanism and may provide
B, Zhivotovsky +2 more
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Current Opinion in Immunology, 1995
Until recently, it was thought that signal transduction through CD28 and the related molecule CTLA4 prevented the induction of anergy in T cells activated through the TCR. This hypothesis has been suggested as an explanation for how soluble forms of CTLA4, which bind the CD28/CTLA4 ligands B7-1 and B7-2, can prevent graft rejection.
L H, Boise, P J, Noel, C B, Thompson
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Until recently, it was thought that signal transduction through CD28 and the related molecule CTLA4 prevented the induction of anergy in T cells activated through the TCR. This hypothesis has been suggested as an explanation for how soluble forms of CTLA4, which bind the CD28/CTLA4 ligands B7-1 and B7-2, can prevent graft rejection.
L H, Boise, P J, Noel, C B, Thompson
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Apoptosis in glomerulonephritis
Rheumatic Disease Clinics of North America, 2004Apoptosis is of fundamental importance and plays a key role in determining the outcome of glomerulonephritis. Under ideal circumstances,apoptosis deletes infiltrating leukocytes and excess numbers of resident cells that are surplus to requirements, thereby facilitating tissue remodeling and the restoration of normal tissue architecture.
Jeremy, Hughes +3 more
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2010
During ageing the immune system is characterized by a peculiar remodelling, called immunosenescence. Apoptosis or programmed cell death plays a central role in this process. Both recurrent antigenic stimulations and oxidative metabolism byproducts, impinging upon the immune system, modify the apoptotic capability of lymphocytes, driving ...
GINALDI, Lia +1 more
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During ageing the immune system is characterized by a peculiar remodelling, called immunosenescence. Apoptosis or programmed cell death plays a central role in this process. Both recurrent antigenic stimulations and oxidative metabolism byproducts, impinging upon the immune system, modify the apoptotic capability of lymphocytes, driving ...
GINALDI, Lia +1 more
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Coronary Artery Disease, 1997
The concept that cells might possess the capacity to self-destruct by a process of programmed cell death, or apoptosis, is rather recent. Interest in this possibility suddenly galvanized when the first death genes were described in round worms 10 years ago.
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The concept that cells might possess the capacity to self-destruct by a process of programmed cell death, or apoptosis, is rather recent. Interest in this possibility suddenly galvanized when the first death genes were described in round worms 10 years ago.
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Current Opinion in Genetics & Development, 2002
Avoidance of apoptosis is a cornerstone of tumourigenesis. The functions of key molecules that either sense DNA damage or that commit cells to die are lost during tumorigenesis. Frequently, during tumourigenesis, cells increase their survival signals. The initiation of apoptosis by DNA damage signals was shown to absolutely depend on the expression of ...
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Avoidance of apoptosis is a cornerstone of tumourigenesis. The functions of key molecules that either sense DNA damage or that commit cells to die are lost during tumorigenesis. Frequently, during tumourigenesis, cells increase their survival signals. The initiation of apoptosis by DNA damage signals was shown to absolutely depend on the expression of ...
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2004
Keratinization is a specialized form of apoptosis that produces the stratum corneum concomitant with keratinocyte cell death. Apoptosis of keratinocytes occurs not only during normal keratinization but also in response to various intracellular or extracellular death stimuli, such as genetic defects or UVB.
Kiyofumi, Yamanishi +2 more
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Keratinization is a specialized form of apoptosis that produces the stratum corneum concomitant with keratinocyte cell death. Apoptosis of keratinocytes occurs not only during normal keratinization but also in response to various intracellular or extracellular death stimuli, such as genetic defects or UVB.
Kiyofumi, Yamanishi +2 more
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