Results 81 to 90 of about 1,427,266 (249)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Glycosylation profiling of triple-negative breast cancer: clinical and immune correlations and identification of LMAN1L as a biomarker and therapeutic target

Frontiers in Immunology
IntroductionBreast cancer (BC) is the most prevalent malignant tumor in women, with triple-negative breast cancer (TNBC) showing the poorest prognosis among all subtypes.
Qianru Yu, Hanyi Zhong, Xinhao Zhu, Chang Liu, Xin Zhang, Jiao Wang, Zongyao Li, Songchang Shi, Haoran Zhao, Cixiang Zhou, Qian Zhao   +10 more
doaj   +1 more source

Selenium modulates inorganic mercury induced cytotoxicity and intrinsic apoptosis in PC12 cells

, 2020
Kaniz Fatima Binte Hossain, Md. Mostafizur Rahman, Md. Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki   +5 more
openalex   +1 more source

Synergistic effect of HIF‐1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition [PDF]

, 2017
Ya‐Fang Chen, Sudhir Pandey, Cecilia Hsuan Day, Yufeng Chen, Ai‐Zhi Jiang, Tsung‐Jung Ho, Ray‐Jade Chen, V. Vijaya Padma, Wei‐Wen Kuo, Chih‐Yang Huang   +9 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Retinal degenerative diseases: role of dietary supplements in retinal health

Discover Food
Retinal degeneration is a progressive condition that affects the retina, the light-sensitive layer, and deteriorates the inner retinal cells that encompass retinal pigment epithelium, photoreceptors, and ganglion cells that are essential for eyesight ...
D. Mohan Kumar, Priti Talwar
doaj   +1 more source

Potential role of SUMO-specific proteases 1 in ferroptosis

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the potential role of SUMO-specific protease 1 (SENP1) in ferroptosis.Methods·The Cancer Genome Atlas (TCGA) database was used to analyze the correlation between the expression levels of SENP1 and the ferroptosis-related genes, acyl ...
XIE Bin, BAI Meng, WU Yan, WO Lulu, HUANG Ying, ZHANG Jing   +5 more
doaj   +1 more source

Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer

, 2023
Ibrahim H. Eissa, Reda G. Yousef, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Hesham A. El‐Mahdy, Hazem Elkady, Ahmed M. Metwaly   +8 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Cancer‐associated V‐ATPase induces delayed apoptosis of protumorigenic neutrophils

, 2020
Safaa A. Ibrahim, Arpita Kulshrestha, Gajendra K. Katara, Valerie Riehl, Manoranjan Sahoo, Kenneth D. Beaman   +5 more
openalex   +1 more source