Results 111 to 120 of about 3,365,976 (292)

A unified therapeutic theory for treating cancer via master regulators of the universal apoptosis network

Cell Death Discovery
Three universal types of cancer are identified, based on the malfunction of a certain set of proteins and regulatory RNAs, irrespective of the organ in which they are located: Cancer Type 1, where cancer cells lack either a functional (a) P14ARF gene, or
Davis Joseph, Florian Kongoli, Fukka You, Haruhiko Inufusa   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Cell cycle regulatory proteins and apoptosis in B-cell chronic lymphocytic leukemia.

Haematologica, 2002
The pathogeny of B-cell chronic lymphocytic leukemia (B-CLL) involves both deregulated proliferation and inhibition of cell death. A particular role in the regulation of these phenomena is played by proteins involved in early G1 phase regulation: pRb kinases: cyclin-dependent kinases (cdk): cdk4 and cdk6 activated by cyclins D, and universal cdk ...
D, Wolowiec, L, Ciszak, A, Kosmaczewska, D, Bocko, R, Teodorowska, I, Frydecka, K, Kuliczkowski   +6 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Optimization of a novel expression system for recombinant protein production in CHO cells

Scientific Reports
Chinese hamster ovary (CHO) cells are common mammalian cell lines for expressing recombinant proteins, yet the expression level of recombinant proteins is still hindered.
Junhe Zhang, Chenyang Du, Yue Pan, Zhan Zhang, Ruoyuan Feng, Mengyao Ma, Tianyun Wang   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Human surfactant protein D alters oxidative stress and HMGA1 expression to induce p53 apoptotic pathway in eosinophil leukemic cell line [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright: © 2013 Mahajan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use ...
Pandit Hrishikesh, Uday Kishore (504246), Ravi Sirdeshmukh, P. Usha Sarma (504245), Curam S Sundaram, Lakshna Mahajan (504239), Madan, T, Ajit K Yadav, Madan Taruna, Poonam Gautam, Ajit K. Yadav (504242), Curam S. Sundaram (504244), Yadav Ajit K., Ravi Sirdeshmukh (131378), Himangi Warke, P. Usha Sarma, Surolia Avadhesha, Warke Himangi, Lakshna Mahajan, Hrishikesh Pandit, Pandit, H, Sundaram, CS, Himangi Warke (504243), Sarma, PU, Poonam Gautam (131332), Sundaram Curam S., Sirdeshmukh Ravi, Sarma P. Usha, Surolia, A, Curam S. Sundaram, Avadhesha Surolia (78297), Mahajan, L, Kishore Uday, Yadav, AK, Sirdeshmukh, R, Warke, H, Taruna Madan, Kishore, U, Taruna Madan (504241), P Usha Sarma, Gautam, P, Mahajan Lakshna, Gautam Poonam, Hrishikesh Pandit (504240), Ajit K. Yadav, Avadhesha Surolia, Uday Kishore   +46 more
core   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Heat shock transcription factor 2 reduces mitochondrial pathway apoptosis in intestinal epithelial cells by inhibiting the increase in mitochondrial membrane permeability in ulcerative colitis.

PLoS ONE
The destruction of intestinal mucosal mechanical barrier homeostasis caused by excessive apoptosis of intestinal epithelial cells (IECs) is an important reason for the occurrence and development of ulcerative colitis (UC).
Wen Wang, Yunling Wen, Juan Luo, Yinglei Miao, Fengrui Zhang, Junkun Niu   +5 more
doaj   +1 more source