Results 111 to 120 of about 446,328 (302)

A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1

Journal of Molecular Signaling, 2010
CARP-1/CCAR1, a perinuclear phospho-protein, regulates signaling by adriamycin, steroids, or growth factors. However, intracellular events that regulate CARP-1-dependent cell growth are not fully understood.Here we investigated whether CARP-1 is involved in signaling induced by the protein kinase A inhibitor H89. Treatments of human breast cancer cells
Jiang, Yan, Puliyappadamba, Vineshkumar T, Zhang, Liyue, Wu, Wenjuan, Wali, Anil, Yaffe, Michael B., Fontana, Joseph A., Rishi, Arun K.   +7 more
openaire   +6 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Targeting C-terminal binding proteins (CtBPs) using genetic selection

, 2011
There are many protein-protein interactions that are vital for cellular processes such as signal transduction, structural organisation and apoptosis. In this study we decipher the role of the protein-protein interaction of C terminal Binding Proteins ...
Nijjar, Sharandip K.
core  

Cellular stress responses: cell survival and cell death [PDF]

, 2010
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells.
Afshin Samali, Hori, Osamu, Gorman, Adrienne M., 26106, Fulda, Simone, 26105, Samali, Afshin, 26107, 60303947, 233, Simone Fulda, Osamu Hori, Adrienne M. Gorman   +12 more
core   +1 more source

Heat shock transcription factor 2 reduces mitochondrial pathway apoptosis in intestinal epithelial cells by inhibiting the increase in mitochondrial membrane permeability in ulcerative colitis.

PLoS ONE
The destruction of intestinal mucosal mechanical barrier homeostasis caused by excessive apoptosis of intestinal epithelial cells (IECs) is an important reason for the occurrence and development of ulcerative colitis (UC).
Wen Wang, Yunling Wen, Juan Luo, Yinglei Miao, Fengrui Zhang, Junkun Niu   +5 more
doaj   +1 more source

Plant caspase-like proteins: from function identification to application in winter rapeseed genetic breeding

Frontiers in Plant Science
Plant programmed cell death (PCD) shares striking similarities with animal apoptosis in both morphological and biochemical characteristics, yet plant genomes lack genuine orthologs of animal caspases.
Tingting Fan, Tingting Fan, Abbas Muhammad Fahim, Abbas Muhammad Fahim, Li Ma, Li Ma, Lijun Liu, Lijun Liu, Yuanyuan Pu, Yuanyuan Pu, Wangtian Wang, Wangtian Wang, Wancang Sun, Wancang Sun, Gang Yang, Gang Yang, Junyan Wu, Junyan Wu   +17 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Cell cycle regulatory proteins and apoptosis in B-cell chronic lymphocytic leukemia.

Haematologica, 2002
The pathogeny of B-cell chronic lymphocytic leukemia (B-CLL) involves both deregulated proliferation and inhibition of cell death. A particular role in the regulation of these phenomena is played by proteins involved in early G1 phase regulation: pRb kinases: cyclin-dependent kinases (cdk): cdk4 and cdk6 activated by cyclins D, and universal cdk ...
D, Wolowiec, L, Ciszak, A, Kosmaczewska, D, Bocko, R, Teodorowska, I, Frydecka, K, Kuliczkowski   +6 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Activation and modulation of antiviral and apoptotic genes in pigs infected with classical swine fever viruses of high, moderate or low virulence [PDF]

, 2009
The immune response to CSFV and the strategies of this virus to evade and suppress the pigs’ immune system are still poorly understood. Therefore, we investigated the transcriptional response in the tonsils, median retropharyngeal lymph node (MRLN), and ...
Hulst, M.M., Loeffen, W.L.A., Wit, A.A.C., de, A. A. C. de Wit, Mastebroek, B., S. V. M. Durand, W. L. A. Loeffen, Durand, S.V.M., L. Mastebroek, M. M. Hulst, de Wit, A.A.C.   +10 more
core   +1 more source