Results 121 to 130 of about 3,365,976 (292)

Plant caspase-like proteins: from function identification to application in winter rapeseed genetic breeding

Frontiers in Plant Science
Plant programmed cell death (PCD) shares striking similarities with animal apoptosis in both morphological and biochemical characteristics, yet plant genomes lack genuine orthologs of animal caspases.
Tingting Fan, Tingting Fan, Abbas Muhammad Fahim, Abbas Muhammad Fahim, Li Ma, Li Ma, Lijun Liu, Lijun Liu, Yuanyuan Pu, Yuanyuan Pu, Wangtian Wang, Wangtian Wang, Wancang Sun, Wancang Sun, Gang Yang, Gang Yang, Junyan Wu, Junyan Wu   +17 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Adenovirus and its interaction with host cell proteins [PDF]

, 2007
The E1B55k gene in adenovirus type 5 was studied by generating recombinant viruses in which the E1B55k gene was N-terminally tagged with either a cyan fluorescent protein (CFP) tag or a tandem affinity purification (TAP) tag.
Carr, Sharon
core   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Structural and functional investigation of the cytoplasmic domain of the Fas death receptor [PDF]

, 2015
Activation of the transmembrane death receptor Fas (CD95/APO-1) by a membrane bound ligand (FasL/CD95L) activates the extrinsic pathway of apoptosis. Intracellular Fas death domains (DDs) are induced to oligomerise enabling binding to the adaptor protein
Wildsmith, GC
core  

Impact of Secondhand Smoke and E-Cigarette Exposure on Placental Apoptotic and Growth-Regulatory Proteins in Mouse Pregnancy

Cells
Apoptosis is critical in placental development, and its dysregulation is linked to pregnancy complications such as intrauterine growth restriction (IUGR) and preeclampsia (PE). Environmental exposures, particularly secondhand smoke (SHS) and e-cigarettes
Logan Beck, Madison N. Kirkham, Marley Shin, Benjamin T. Bikman, Paul R. Reynolds, Juan A. Arroyo   +5 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The Role of Metacaspases and Other Proteins Involved in the Apoptosis of Leishmania: Review Article

Iranian Journal of Parasitology
Background: Apoptosis, a determined form of programmed cell death (PCD), occurs in multi-cellular and single-celled organisms. Given that a general understanding of apoptosis in single-cell Leishmania is crucial for designing disease control policies ...
Maryam Aghaei, Shahrzad Aghaei, Zabihollah Shahmoradi, Seyed Hossein Hejazi   +3 more
doaj  

Effect of fibrinogen like protein 1 on cisplatin-resistance in laryngeal carcinoma through targeting integrinβ1 in vivo and in vitro

Discover Oncology
Objective To explore the relationship between fibrinogen like protein 1 (FGL1) and cisplatin (CDDP) resistance in laryngeal carcinoma, as well as dissect the underlying molecular regulatory pathways.
Zhen Li, Jianlin Fang, Hongzhou Ge, Xiaoyong Wang, Hui Dong, Hang Yu, Yansha Liu, Tao Li   +7 more
doaj   +1 more source