Results 251 to 260 of about 3,365,976 (292)

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Targeting Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs): A Novel Therapeutic Strategy for Diabetic Complications. [PDF]

Diabetes Metab Syndr Obes
Shi J, Sun X, You J, Ji X, Xie J, Li Y, Gu K, Wei X.   +7 more
europepmc   +1 more source

Post-Translational Modifications in Traumatic Brain Injury: Decoding the Proteomic Landscape and Molecular Mechanisms of Secondary Injury. [PDF]

FASEB J
Shen P, Li L, Zhang Z, Zong L.
europepmc   +1 more source

Post-translational modifications of mitochondrion-related proteins: integrative orchestrators of cell fate networks in cardiovascular disease. [PDF]

Cell Commun Signal
Liu L, Wu S, Zhang L, Zhong L, Guo R.
europepmc   +1 more source

Ribosome biogenesis in osteoarthritis: mechanisms and therapeutic potential. [PDF]

J Transl Med
Xu Z, Pei Z, Yang H, Guo S, Li Q, Jiang L, Wang J, Wang L, Liu D, Chen X, Zhang B, Hao T.   +11 more
europepmc   +1 more source

miR-27b-3p Exacerbates VCD-Induced KGN Cell Injury by Targeting PAPPA to Suppress IGF-1 Release and Inhibit the PI3K/AKT Pathway. [PDF]

Genes (Basel)
Zhang M, Meng X, Shi M, Ge P.
europepmc   +1 more source

PFKM Modulates Porcine Skeletal Muscle Satellite Cell Differentiation Through Metabolic and Mitochondrial Pathways. [PDF]

Vet Sci
Hou X, Yang Y, Wei R, Cui X, Jiang H, Ju H.   +5 more
europepmc   +1 more source

Apoptosis and expression of its regulatory proteins in soft tissue sarcomas

Apoptosis and expression of its regulatory proteins in soft tissue sarcomas
openaire   +1 more source