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Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis
Cellular Signalling, 2013IAPs are a group of regulatory proteins that are structurally related. Their conserved homologues have been identified in various organisms. In human, eight IAP members have been recognized based on baculoviral IAP repeat (BIR) domains. IAPs are key regulators of apoptosis, cytokinesis and signal transduction. The antiapoptotic property of IAPs depends
Kewei Wang, Bingliang Lin
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Apoptosis and expression of its regulatory proteins in soft tissue sarcomas
Cancer Letters, 2002Information for the occurrence and extent of apoptosis in soft tissue sarcoma (STS) and their clinical implication are limited. In 102 cases of STSs, apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling method and expression of Bcl-2, Bax, MIB-1 and p53 protein was examined immunohistochemically. The apoptotic
Aki Yoshida, Yuki Morimoto
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Journal of Neuroimmunology, 2002
The pathogenesis of multiple sclerosis (MS) is thought to involve T- and B-lymphocyte-mediated autoimmunity. However, the mechanisms that regulate lymphocyte activity in MS are poorly understood. In normal circumstances, programmed cell death (apoptosis) contributes to the maintenance of lymphocytes homeostasis and the deletion of autoreactive cells ...
M K Sharief, M K Sharief
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The pathogenesis of multiple sclerosis (MS) is thought to involve T- and B-lymphocyte-mediated autoimmunity. However, the mechanisms that regulate lymphocyte activity in MS are poorly understood. In normal circumstances, programmed cell death (apoptosis) contributes to the maintenance of lymphocytes homeostasis and the deletion of autoreactive cells ...
M K Sharief, M K Sharief
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Expression of apoptosis-regulatory proteins in lesions of pulmonary Langerhans cell histiocytosis
Histopathology, 2004Aims: Pulmonary Langerhans cell histiocytosis (PLCH) is characterized by the presence of lesions containing numerous activated Langerhans cells (LCs). An uncontrolled immune response sustained by activated LCs seems to be involved in the pathogenesis of the disease.
J, Marchal +4 more
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Neurochemical Research, 2004
There is increasing evidence that proteins normally involved in the cell cycle play a role in the regulation of neuronal apoptotic death following various insults. However, it is not clear if the same mechanisms regulate cell death of oligodendrocytes as well.
Strazza M. +7 more
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There is increasing evidence that proteins normally involved in the cell cycle play a role in the regulation of neuronal apoptotic death following various insults. However, it is not clear if the same mechanisms regulate cell death of oligodendrocytes as well.
Strazza M. +7 more
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Evaluation of apoptosis regulatory proteins in response to
SummaryBackgroundThe histopathologic changes characteristic of psoriasis might be related to suppressed apoptosis. One of the actions of psoralen ultraviolet A (PUVA) in psoriasis could be exerted through induction of apoptosis of keratinocytes and lymphocytes; however, its exact molecular mechanism is still confusing.AimIn this study, we evaluated the
Moetaz, El-Domyati +5 more
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Alteration of caspases and other apoptosis regulatory proteins in Down syndrome
2001Apoptosis has been implicated in the selective neuronal loss of Down syndrome (DS). Apoptosis activates a family of cysteine proteases with specificity for aspartic acid residues referred to as caspases that play a key role in dismantling a cell committed to die.
T, Gulesserian +4 more
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The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system
Seminars in Immunology, 1997Bcl-2 was the first recognized component of the physiological cell death mechanism. It belongs to an expanding family of proteins that regulate apoptosis during development and homeostasis. Experiments using transgenic and gene knockout mice have revealed much about the roles played by Bcl-2, Bcl-x and Bax in regulating apoptosis in the immune system ...
C J, Hawkins, D L, Vaux
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American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007
Although the regulatory mechanisms for the age-related rise in proliferation and reduction in apoptosis in the colonic mucosa are yet to be fully delineated, we have demonstrated that these events are associated with increased expression and activation of epithelial growth factor receptor (EGFR)/ErbB-1 and some of its receptor family members (EGFRs ...
Adhip P N, Majumdar +6 more
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Although the regulatory mechanisms for the age-related rise in proliferation and reduction in apoptosis in the colonic mucosa are yet to be fully delineated, we have demonstrated that these events are associated with increased expression and activation of epithelial growth factor receptor (EGFR)/ErbB-1 and some of its receptor family members (EGFRs ...
Adhip P N, Majumdar +6 more
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Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis
American Journal of Physiology-Renal Physiology, 2000The response to glomerular and tubulointerstitial cell injury in most forms of renal disease includes changes in cell number (proliferation and apoptosis) and cell size (hyerptrophy). These events typically precede and may be reponsible for the accumulation of extracellular matrix proteins that leads to a decrease in renal function. There is increasing
S J, Shankland, G, Wolf
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